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Bromine in PDB 7ovk: Protein Kinase MKK7 in Complex with 5-Bromo-2-Hydroxyphenyl- Substituted PyrazolopyrimidineEnzymatic activity of Protein Kinase MKK7 in Complex with 5-Bromo-2-Hydroxyphenyl- Substituted Pyrazolopyrimidine
All present enzymatic activity of Protein Kinase MKK7 in Complex with 5-Bromo-2-Hydroxyphenyl- Substituted Pyrazolopyrimidine:
2.7.12.2; Protein crystallography data
The structure of Protein Kinase MKK7 in Complex with 5-Bromo-2-Hydroxyphenyl- Substituted Pyrazolopyrimidine, PDB code: 7ovk
was solved by
S.Kleinboelting,
M.Buehrmann,
M.P.Mueller,
D.Rauh,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the Protein Kinase MKK7 in Complex with 5-Bromo-2-Hydroxyphenyl- Substituted Pyrazolopyrimidine
(pdb code 7ovk). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Protein Kinase MKK7 in Complex with 5-Bromo-2-Hydroxyphenyl- Substituted Pyrazolopyrimidine, PDB code: 7ovk: Bromine binding site 1 out of 1 in 7ovkGo back to Bromine Binding Sites List in 7ovk
Bromine binding site 1 out
of 1 in the Protein Kinase MKK7 in Complex with 5-Bromo-2-Hydroxyphenyl- Substituted Pyrazolopyrimidine
Mono view Stereo pair view
Reference:
P.Gehrtz,
S.Marom,
M.Buhrmann,
J.Hardick,
S.Kleinbolting,
A.Shraga,
C.Dubiella,
R.Gabizon,
J.N.Wiese,
M.P.Muller,
G.Cohen,
I.Babaev,
K.Shurrush,
L.Avram,
E.Resnick,
H.Barr,
D.Rauh,
N.London.
Optimization of Covalent MKK7 Inhibitors Via Crude Nanomole-Scale Libraries. J.Med.Chem. V. 65 10341 2022.
Page generated: Tue Apr 4 17:34:21 2023
ISSN: ISSN 0022-2623 PubMed: 35912476 DOI: 10.1021/ACS.JMEDCHEM.1C02206 |
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