Bromine in PDB 7r4n: Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl- 1H-Indazole-3-Carboxamide

Enzymatic activity of Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl- 1H-Indazole-3-Carboxamide

All present enzymatic activity of Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl- 1H-Indazole-3-Carboxamide:
1.1.3.15;

Protein crystallography data

The structure of Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl- 1H-Indazole-3-Carboxamide, PDB code: 7r4n was solved by S.Mackinnon, G.A.Bezerra, T.Krojer, A.R.Bradley, R.Talon, J.Brandeo-Neto, A.Douangamath, F.Von Delft, C.H.Arrowsmith, A.Edwards, C.Bountra, U.Oppermann, P.E.Brennan, W.W.Yue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 62.09 / 1.70
Space group I 4
Cell size a, b, c (Å), α, β, γ (°) 97, 97, 80.64, 90, 90, 90
R / Rfree (%) 16.2 / 19.4

Bromine Binding Sites:

The binding sites of Bromine atom in the Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl- 1H-Indazole-3-Carboxamide (pdb code 7r4n). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl- 1H-Indazole-3-Carboxamide, PDB code: 7r4n:

Bromine binding site 1 out of 1 in 7r4n

Go back to Bromine Binding Sites List in 7r4n
Bromine binding site 1 out of 1 in the Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl- 1H-Indazole-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl- 1H-Indazole-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br602

b:44.3
occ:1.00
 BR A:7RI602 0.0 44.3 1.0
C12 A:7RI602 1.9 34.5 1.0
CE A:MET82 2.5 30.8 1.0
C11 A:7RI602 2.7 30.8 1.0
SD A:MET82 2.8 30.1 1.0
C09 A:7RI602 2.8 31.7 1.0
CE A:MET183 2.9 31.2 1.0
CG A:MET82 3.8 28.7 1.0
C10 A:7RI602 3.9 28.5 1.0
CD1 A:TRP110 3.9 20.7 0.4
NE1 A:TRP110 4.0 17.5 0.4
C08 A:7RI602 4.1 33.4 1.0
CB A:ALA81 4.1 23.1 1.0
C07 A:7RI602 4.5 31.0 1.0
OH A:TYR26 4.5 23.4 1.0
SD A:MET183 4.5 32.3 1.0
CB A:LEU205 4.8 27.8 1.0
CB A:MET82 4.9 29.3 1.0

Reference:

S.Mackinnon, G.A.Bezerra, T.Krojer, A.R.Bradley, R.Talon, J.Brandeo-Neto, A.Douangamath, F.Von Delft, C.H.Arrowsmith, A.Edwards, C.Bountra, U.Oppermann, P.E.Brennan, W.W.Yue. Structure of Human Hydroxyacid Oxidase 1 Bound with 5-Bromo-N-Methyl-1H-Indazole-3-Carboxamide To Be Published.
Page generated: Thu Jul 11 04:30:43 2024

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