Bromine in PDB 8e6t: Human TRPM2 Ion Channel in 1 Mm Br-Adpr

Bromine Binding Sites:

The binding sites of Bromine atom in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr (pdb code 8e6t). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 8 binding sites of Bromine where determined in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr, PDB code: 8e6t:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Bromine binding site 1 out of 8 in 8e6t

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Bromine binding site 1 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1601

b:80.5
occ:1.00
 BR10 A:UOO1601 0.0 80.5 1.0
C09 A:UOO1601 1.9 80.5 1.0
N11 A:UOO1601 2.9 80.5 1.0
N08 A:UOO1601 2.9 80.5 1.0
C12 A:UOO1601 3.3 80.5 1.0
O37 A:UOO1601 3.4 80.5 1.0
O A:ASN273 3.9 38.5 1.0
CE2 A:TYR295 4.1 57.2 1.0
OG1 A:THR275 4.1 43.0 1.0
C06 A:UOO1601 4.1 80.5 1.0
C07 A:UOO1601 4.1 80.5 1.0
OH A:TYR295 4.2 57.2 1.0
CZ A:TYR295 4.6 57.2 1.0
C13 A:UOO1601 4.9 80.5 1.0
C A:ASN273 5.0 38.5 1.0

Bromine binding site 2 out of 8 in 8e6t

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Bromine binding site 2 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1602

b:127.8
occ:1.00
 BR10 A:UOO1602 0.0 127.8 1.0
C09 A:UOO1602 1.9 127.8 1.0
N11 A:UOO1602 2.9 127.8 1.0
N08 A:UOO1602 2.9 127.8 1.0
O14 A:UOO1602 3.1 127.8 1.0
C13 A:UOO1602 3.3 127.8 1.0
C12 A:UOO1602 3.4 127.8 1.0
CG A:PRO1432 3.5 65.5 1.0
CE1 A:TYR1485 3.7 74.4 1.0
CD1 A:TYR1485 4.1 74.4 1.0
C07 A:UOO1602 4.1 127.8 1.0
C06 A:UOO1602 4.1 127.8 1.0
CB A:PRO1432 4.4 65.5 1.0
CZ A:TYR1485 4.5 74.4 1.0
CD A:PRO1432 4.6 65.5 1.0
O37 A:UOO1602 4.7 127.8 1.0
OH A:TYR1485 4.8 74.4 1.0
C15 A:UOO1602 4.9 127.8 1.0

Bromine binding site 3 out of 8 in 8e6t

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Bromine binding site 3 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Br1601

b:83.7
occ:1.00
 BR10 B:UOO1601 0.0 83.7 1.0
C09 B:UOO1601 1.9 83.7 1.0
N11 B:UOO1601 2.9 83.7 1.0
N08 B:UOO1601 2.9 83.7 1.0
C12 B:UOO1601 3.3 83.7 1.0
O37 B:UOO1601 3.4 83.7 1.0
O B:ASN273 3.9 50.3 1.0
CE2 B:TYR295 4.1 59.7 1.0
OG1 B:THR275 4.1 59.1 1.0
C06 B:UOO1601 4.1 83.7 1.0
C07 B:UOO1601 4.1 83.7 1.0
OH B:TYR295 4.2 59.7 1.0
CZ B:TYR295 4.6 59.7 1.0
C13 B:UOO1601 4.9 83.7 1.0
C B:ASN273 5.0 50.3 1.0

Bromine binding site 4 out of 8 in 8e6t

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Bromine binding site 4 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Br1602

b:133.0
occ:1.00
 BR10 B:UOO1602 0.0 133.0 1.0
C09 B:UOO1602 1.9 133.0 1.0
N08 B:UOO1602 2.9 133.0 1.0
N11 B:UOO1602 2.9 133.0 1.0
O14 B:UOO1602 3.1 133.0 1.0
C13 B:UOO1602 3.3 133.0 1.0
C12 B:UOO1602 3.4 133.0 1.0
CG B:PRO1432 3.5 69.6 1.0
CE1 B:TYR1485 3.7 72.6 1.0
CD1 B:TYR1485 4.1 72.6 1.0
C07 B:UOO1602 4.1 133.0 1.0
C06 B:UOO1602 4.1 133.0 1.0
CB B:PRO1432 4.4 69.6 1.0
CZ B:TYR1485 4.5 72.6 1.0
CD B:PRO1432 4.6 69.6 1.0
O37 B:UOO1602 4.7 133.0 1.0
OH B:TYR1485 4.8 72.6 1.0
C15 B:UOO1602 4.9 133.0 1.0

Bromine binding site 5 out of 8 in 8e6t

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Bromine binding site 5 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Br1601

b:77.0
occ:1.00
 BR10 C:UOO1601 0.0 77.0 1.0
C09 C:UOO1601 1.9 77.0 1.0
N11 C:UOO1601 2.9 77.0 1.0
N08 C:UOO1601 2.9 77.0 1.0
C12 C:UOO1601 3.3 77.0 1.0
O37 C:UOO1601 3.4 77.0 1.0
O C:ASN273 3.9 44.0 1.0
CE2 C:TYR295 4.1 61.4 1.0
OG1 C:THR275 4.1 55.9 1.0
C06 C:UOO1601 4.1 77.0 1.0
C07 C:UOO1601 4.1 77.0 1.0
OH C:TYR295 4.2 61.4 1.0
CZ C:TYR295 4.6 61.4 1.0
C13 C:UOO1601 4.9 77.0 1.0
C C:ASN273 5.0 44.0 1.0

Bromine binding site 6 out of 8 in 8e6t

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Bromine binding site 6 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 6 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Br1602

b:130.8
occ:1.00
 BR10 C:UOO1602 0.0 130.8 1.0
C09 C:UOO1602 1.9 130.8 1.0
N11 C:UOO1602 2.9 130.8 1.0
N08 C:UOO1602 2.9 130.8 1.0
O14 C:UOO1602 3.1 130.8 1.0
C13 C:UOO1602 3.3 130.8 1.0
C12 C:UOO1602 3.4 130.8 1.0
CG C:PRO1432 3.5 69.1 1.0
CE1 C:TYR1485 3.7 75.8 1.0
CD1 C:TYR1485 4.1 75.8 1.0
C07 C:UOO1602 4.1 130.8 1.0
C06 C:UOO1602 4.1 130.8 1.0
CB C:PRO1432 4.4 69.1 1.0
CZ C:TYR1485 4.5 75.8 1.0
CD C:PRO1432 4.6 69.1 1.0
O37 C:UOO1602 4.7 130.8 1.0
OH C:TYR1485 4.9 75.8 1.0
C15 C:UOO1602 4.9 130.8 1.0

Bromine binding site 7 out of 8 in 8e6t

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Bromine binding site 7 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 7 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Br1601

b:78.4
occ:1.00
 BR10 D:UOO1601 0.0 78.4 1.0
C09 D:UOO1601 1.9 78.4 1.0
N11 D:UOO1601 2.9 78.4 1.0
N08 D:UOO1601 2.9 78.4 1.0
C12 D:UOO1601 3.3 78.4 1.0
O37 D:UOO1601 3.4 78.4 1.0
O D:ASN273 3.9 53.5 1.0
CE2 D:TYR295 4.1 61.3 1.0
C06 D:UOO1601 4.1 78.4 1.0
OG1 D:THR275 4.1 61.2 1.0
C07 D:UOO1601 4.1 78.4 1.0
OH D:TYR295 4.2 61.3 1.0
CZ D:TYR295 4.6 61.3 1.0
C13 D:UOO1601 4.9 78.4 1.0
C D:ASN273 5.0 53.5 1.0

Bromine binding site 8 out of 8 in 8e6t

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Bromine binding site 8 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 8 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Br1602

b:139.8
occ:1.00
 BR10 D:UOO1602 0.0 139.8 1.0
C09 D:UOO1602 1.9 139.8 1.0
N11 D:UOO1602 2.9 139.8 1.0
N08 D:UOO1602 2.9 139.8 1.0
O14 D:UOO1602 3.1 139.8 1.0
C13 D:UOO1602 3.3 139.8 1.0
C12 D:UOO1602 3.4 139.8 1.0
CG D:PRO1432 3.5 70.8 1.0
CE1 D:TYR1485 3.7 75.0 1.0
CD1 D:TYR1485 4.1 75.0 1.0
C07 D:UOO1602 4.1 139.8 1.0
C06 D:UOO1602 4.1 139.8 1.0
CB D:PRO1432 4.4 70.8 1.0
CZ D:TYR1485 4.5 75.0 1.0
CD D:PRO1432 4.6 70.8 1.0
O37 D:UOO1602 4.7 139.8 1.0
OH D:TYR1485 4.9 75.0 1.0
C15 D:UOO1602 4.9 139.8 1.0

Reference:

L.Wang, T.-M.Fu. A Unified Mechanism For Human TRPM2 Activation, Desensitization and Inhibition To Be Published.
Page generated: Sat Sep 28 08:39:01 2024

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