Bromine in PDB 8u43: TRPV1 in Nanodisc Bound with PIP2-BR4

The structure of TRPV1 in Nanodisc Bound with PIP2-BR4 also contains other interesting chemical elements:

Sodium

(Na)

1 atom

The binding sites of Bromine atom in the TRPV1 in Nanodisc Bound with PIP2-BR4 (pdb code 8u43). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 8 binding sites of Bromine where determined in the TRPV1 in Nanodisc Bound with PIP2-BR4, PDB code: 8u43:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Bromine binding site 1 out of 8 in the TRPV1 in Nanodisc Bound with PIP2-BR4


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of TRPV1 in Nanodisc Bound with PIP2-BR4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br801 b:63.3 occ:1.00 BR10 A:V5H801 0.0 63.3 1.0 C09 A:V5H801 1.9 63.3 1.0 H091 A:V5H801 2.5 63.3 1.0 BR12 A:V5H801 2.7 63.3 1.0 C11 A:V5H801 2.8 63.3 1.0 H082 A:V5H801 2.8 63.3 1.0 C08 A:V5H801 2.9 63.3 1.0 H061 A:V5H801 3.1 63.3 1.0 H111 A:V5H801 3.3 63.3 1.0 H071 A:V5H801 3.5 63.3 1.0 C07 A:V5H801 3.5 63.3 1.0 C06 A:V5H801 3.8 63.3 1.0 H081 A:V5H801 3.8 63.3 1.0 H20 A:PCW802 3.9 20.0 1.0 H131 A:V5H801 4.1 63.3 1.0 C13 A:V5H801 4.1 63.3 1.0 H062 A:V5H801 4.2 63.3 1.0 H19 A:PCW802 4.3 20.0 1.0 C20 A:PCW802 4.4 20.0 1.0 HD22 A:LEU515 4.4 59.2 1.0 HD23 A:LEU515 4.5 59.2 1.0 HE3 A:MET547 4.6 52.4 1.0 H072 A:V5H801 4.6 63.3 1.0 C19 A:PCW802 4.6 20.0 1.0 H132 A:V5H801 4.7 63.3 1.0 O A:HOH912 4.7 75.2 1.0 H562 A:V5H801 4.8 63.3 1.0 HG1 A:THR550 4.9 50.0 1.0 H032 A:V5H801 4.9 63.3 1.0 H141 A:V5H801 4.9 63.3 1.0 CD2 A:LEU515 4.9 59.2 1.0 HD13 D:LEU669 5.0 47.1 1.0

Bromine binding site 2 out of 8 in the TRPV1 in Nanodisc Bound with PIP2-BR4


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of TRPV1 in Nanodisc Bound with PIP2-BR4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br801 b:63.3 occ:1.00 BR12 A:V5H801 0.0 63.3 1.0 C11 A:V5H801 1.9 63.3 1.0 H111 A:V5H801 2.5 63.3 1.0 C13 A:V5H801 2.5 63.3 1.0 H141 A:V5H801 2.6 63.3 1.0 H131 A:V5H801 2.6 63.3 1.0 BR10 A:V5H801 2.7 63.3 1.0 C14 A:V5H801 2.8 63.3 1.0 C09 A:V5H801 2.8 63.3 1.0 H142 A:V5H801 2.8 63.3 1.0 H562 A:V5H801 3.4 63.3 1.0 H132 A:V5H801 3.6 63.3 1.0 H091 A:V5H801 3.6 63.3 1.0 HD22 D:LEU669 3.6 47.1 1.0 C56 A:V5H801 3.7 63.3 1.0 H082 A:V5H801 3.7 63.3 1.0 C08 A:V5H801 3.8 63.3 1.0 H171 A:V5H801 3.9 63.3 1.0 H541 A:V5H801 3.9 63.3 1.0 H081 A:V5H801 4.1 63.3 1.0 H563 A:V5H801 4.2 63.3 1.0 C15 A:V5H801 4.2 63.3 1.0 HD13 A:ILE573 4.3 53.9 1.0 HD12 D:LEU669 4.4 47.1 1.0 CD2 D:LEU669 4.6 47.1 1.0 HD23 A:LEU515 4.6 59.2 1.0 H152 A:V5H801 4.7 63.3 1.0 H151 A:V5H801 4.7 63.3 1.0 C17 A:V5H801 4.8 63.3 1.0 C54 A:V5H801 4.9 63.3 1.0 HD23 D:LEU669 4.9 47.1 1.0 C16 A:V5H801 4.9 63.3 1.0 C55 A:V5H801 4.9 63.3 1.0 H162 A:V5H801 4.9 63.3 1.0 HD22 A:LEU515 5.0 59.2 1.0 O A:HOH912 5.0 75.2 1.0 HD21 D:LEU669 5.0 47.1 1.0

Bromine binding site 3 out of 8 in the TRPV1 in Nanodisc Bound with PIP2-BR4


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of TRPV1 in Nanodisc Bound with PIP2-BR4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Br801 b:63.3 occ:1.00 BR10 B:V5H801 0.0 63.3 1.0 C09 B:V5H801 1.9 63.3 1.0 H091 B:V5H801 2.5 63.3 1.0 BR12 B:V5H801 2.7 63.3 1.0 C11 B:V5H801 2.8 63.3 1.0 H082 B:V5H801 2.8 63.3 1.0 C08 B:V5H801 2.9 63.3 1.0 H061 B:V5H801 3.1 63.3 1.0 H111 B:V5H801 3.3 63.3 1.0 H071 B:V5H801 3.5 63.3 1.0 C07 B:V5H801 3.6 63.3 1.0 C06 B:V5H801 3.8 63.3 1.0 H081 B:V5H801 3.8 63.3 1.0 H20 B:PCW802 3.9 20.0 1.0 H131 B:V5H801 4.1 63.3 1.0 C13 B:V5H801 4.1 63.3 1.0 H062 B:V5H801 4.2 63.3 1.0 H19 B:PCW802 4.3 20.0 1.0 C20 B:PCW802 4.4 20.0 1.0 HD22 B:LEU515 4.4 59.2 1.0 HD23 B:LEU515 4.5 59.2 1.0 HE3 B:MET547 4.6 52.4 1.0 H072 B:V5H801 4.6 63.3 1.0 C19 B:PCW802 4.6 20.0 1.0 H132 B:V5H801 4.7 63.3 1.0 O B:HOH912 4.7 75.2 1.0 H562 B:V5H801 4.8 63.3 1.0 HG1 B:THR550 4.9 50.0 1.0 H032 B:V5H801 4.9 63.3 1.0 H141 B:V5H801 4.9 63.3 1.0 CD2 B:LEU515 4.9 59.2 1.0 HD13 A:LEU669 5.0 47.1 1.0

Bromine binding site 4 out of 8 in the TRPV1 in Nanodisc Bound with PIP2-BR4


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of TRPV1 in Nanodisc Bound with PIP2-BR4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Br801 b:63.3 occ:1.00 BR12 B:V5H801 0.0 63.3 1.0 C11 B:V5H801 1.9 63.3 1.0 H111 B:V5H801 2.5 63.3 1.0 C13 B:V5H801 2.5 63.3 1.0 H141 B:V5H801 2.6 63.3 1.0 H131 B:V5H801 2.6 63.3 1.0 BR10 B:V5H801 2.7 63.3 1.0 C14 B:V5H801 2.8 63.3 1.0 C09 B:V5H801 2.8 63.3 1.0 H142 B:V5H801 2.8 63.3 1.0 H562 B:V5H801 3.4 63.3 1.0 H132 B:V5H801 3.6 63.3 1.0 H091 B:V5H801 3.6 63.3 1.0 HD22 A:LEU669 3.6 47.1 1.0 C56 B:V5H801 3.7 63.3 1.0 H082 B:V5H801 3.7 63.3 1.0 C08 B:V5H801 3.8 63.3 1.0 H171 B:V5H801 3.9 63.3 1.0 H541 B:V5H801 3.9 63.3 1.0 H081 B:V5H801 4.1 63.3 1.0 H563 B:V5H801 4.2 63.3 1.0 C15 B:V5H801 4.2 63.3 1.0 HD13 B:ILE573 4.3 53.9 1.0 HD12 A:LEU669 4.4 47.1 1.0 CD2 A:LEU669 4.6 47.1 1.0 HD23 B:LEU515 4.6 59.2 1.0 H152 B:V5H801 4.7 63.3 1.0 H151 B:V5H801 4.7 63.3 1.0 C17 B:V5H801 4.8 63.3 1.0 C54 B:V5H801 4.9 63.3 1.0 HD23 A:LEU669 4.9 47.1 1.0 C16 B:V5H801 4.9 63.3 1.0 C55 B:V5H801 4.9 63.3 1.0 H162 B:V5H801 4.9 63.3 1.0 HD22 B:LEU515 5.0 59.2 1.0 O B:HOH912 5.0 75.2 1.0 HD21 A:LEU669 5.0 47.1 1.0

Bromine binding site 5 out of 8 in the TRPV1 in Nanodisc Bound with PIP2-BR4


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of TRPV1 in Nanodisc Bound with PIP2-BR4 within 5.0Å range: probe atom residue distance (Å) B Occ C:Br801 b:63.3 occ:1.00 BR10 C:V5H801 0.0 63.3 1.0 C09 C:V5H801 1.9 63.3 1.0 H091 C:V5H801 2.5 63.3 1.0 BR12 C:V5H801 2.7 63.3 1.0 C11 C:V5H801 2.8 63.3 1.0 H082 C:V5H801 2.8 63.3 1.0 C08 C:V5H801 2.9 63.3 1.0 H061 C:V5H801 3.1 63.3 1.0 H111 C:V5H801 3.3 63.3 1.0 H071 C:V5H801 3.5 63.3 1.0 C07 C:V5H801 3.6 63.3 1.0 C06 C:V5H801 3.8 63.3 1.0 H081 C:V5H801 3.8 63.3 1.0 H20 C:PCW802 3.9 20.0 1.0 H131 C:V5H801 4.1 63.3 1.0 C13 C:V5H801 4.1 63.3 1.0 H062 C:V5H801 4.2 63.3 1.0 H19 C:PCW802 4.3 20.0 1.0 C20 C:PCW802 4.4 20.0 1.0 HD22 C:LEU515 4.4 59.2 1.0 HD23 C:LEU515 4.5 59.2 1.0 HE3 C:MET547 4.6 52.4 1.0 H072 C:V5H801 4.6 63.3 1.0 C19 C:PCW802 4.6 20.0 1.0 H132 C:V5H801 4.7 63.3 1.0 O C:HOH912 4.7 75.2 1.0 H562 C:V5H801 4.8 63.3 1.0 HG1 C:THR550 4.9 50.0 1.0 H032 C:V5H801 4.9 63.3 1.0 H141 C:V5H801 4.9 63.3 1.0 CD2 C:LEU515 4.9 59.2 1.0 HD13 B:LEU669 5.0 47.1 1.0

Bromine binding site 6 out of 8 in the TRPV1 in Nanodisc Bound with PIP2-BR4


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 6 of TRPV1 in Nanodisc Bound with PIP2-BR4 within 5.0Å range: probe atom residue distance (Å) B Occ C:Br801 b:63.3 occ:1.00 BR12 C:V5H801 0.0 63.3 1.0 C11 C:V5H801 1.9 63.3 1.0 H111 C:V5H801 2.5 63.3 1.0 C13 C:V5H801 2.5 63.3 1.0 H141 C:V5H801 2.6 63.3 1.0 H131 C:V5H801 2.6 63.3 1.0 BR10 C:V5H801 2.7 63.3 1.0 C14 C:V5H801 2.8 63.3 1.0 C09 C:V5H801 2.8 63.3 1.0 H142 C:V5H801 2.8 63.3 1.0 H562 C:V5H801 3.4 63.3 1.0 H132 C:V5H801 3.6 63.3 1.0 H091 C:V5H801 3.6 63.3 1.0 HD22 B:LEU669 3.6 47.1 1.0 C56 C:V5H801 3.7 63.3 1.0 H082 C:V5H801 3.7 63.3 1.0 C08 C:V5H801 3.8 63.3 1.0 H171 C:V5H801 3.9 63.3 1.0 H541 C:V5H801 3.9 63.3 1.0 H081 C:V5H801 4.1 63.3 1.0 H563 C:V5H801 4.2 63.3 1.0 C15 C:V5H801 4.2 63.3 1.0 HD13 C:ILE573 4.3 53.9 1.0 HD12 B:LEU669 4.4 47.1 1.0 CD2 B:LEU669 4.6 47.1 1.0 HD23 C:LEU515 4.6 59.2 1.0 H152 C:V5H801 4.7 63.3 1.0 H151 C:V5H801 4.7 63.3 1.0 C17 C:V5H801 4.8 63.3 1.0 C54 C:V5H801 4.9 63.3 1.0 HD23 B:LEU669 4.9 47.1 1.0 C16 C:V5H801 4.9 63.3 1.0 C55 C:V5H801 4.9 63.3 1.0 H162 C:V5H801 4.9 63.3 1.0 HD22 C:LEU515 5.0 59.2 1.0 O C:HOH912 5.0 75.2 1.0 HD21 B:LEU669 5.0 47.1 1.0

Bromine binding site 7 out of 8 in the TRPV1 in Nanodisc Bound with PIP2-BR4


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 7 of TRPV1 in Nanodisc Bound with PIP2-BR4 within 5.0Å range: probe atom residue distance (Å) B Occ D:Br801 b:63.3 occ:1.00 BR10 D:V5H801 0.0 63.3 1.0 C09 D:V5H801 1.9 63.3 1.0 H091 D:V5H801 2.5 63.3 1.0 BR12 D:V5H801 2.7 63.3 1.0 C11 D:V5H801 2.8 63.3 1.0 H082 D:V5H801 2.8 63.3 1.0 C08 D:V5H801 2.9 63.3 1.0 H061 D:V5H801 3.1 63.3 1.0 H111 D:V5H801 3.3 63.3 1.0 H071 D:V5H801 3.5 63.3 1.0 C07 D:V5H801 3.5 63.3 1.0 C06 D:V5H801 3.8 63.3 1.0 H081 D:V5H801 3.8 63.3 1.0 H20 D:PCW802 3.9 20.0 1.0 H131 D:V5H801 4.1 63.3 1.0 C13 D:V5H801 4.1 63.3 1.0 H062 D:V5H801 4.2 63.3 1.0 H19 D:PCW802 4.3 20.0 1.0 C20 D:PCW802 4.4 20.0 1.0 HD22 D:LEU515 4.4 59.2 1.0 HD23 D:LEU515 4.5 59.2 1.0 HE3 D:MET547 4.6 52.4 1.0 H072 D:V5H801 4.6 63.3 1.0 C19 D:PCW802 4.6 20.0 1.0 H132 D:V5H801 4.7 63.3 1.0 O D:HOH912 4.7 75.2 1.0 H562 D:V5H801 4.8 63.3 1.0 HG1 D:THR550 4.9 50.0 1.0 H032 D:V5H801 4.9 63.3 1.0 H141 D:V5H801 4.9 63.3 1.0 CD2 D:LEU515 4.9 59.2 1.0 HD13 C:LEU669 5.0 47.1 1.0

Bromine binding site 8 out of 8 in the TRPV1 in Nanodisc Bound with PIP2-BR4


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 8 of TRPV1 in Nanodisc Bound with PIP2-BR4 within 5.0Å range: probe atom residue distance (Å) B Occ D:Br801 b:63.3 occ:1.00 BR12 D:V5H801 0.0 63.3 1.0 C11 D:V5H801 1.9 63.3 1.0 H111 D:V5H801 2.5 63.3 1.0 C13 D:V5H801 2.5 63.3 1.0 H141 D:V5H801 2.6 63.3 1.0 H131 D:V5H801 2.6 63.3 1.0 BR10 D:V5H801 2.7 63.3 1.0 C14 D:V5H801 2.8 63.3 1.0 C09 D:V5H801 2.8 63.3 1.0 H142 D:V5H801 2.8 63.3 1.0 H562 D:V5H801 3.4 63.3 1.0 H132 D:V5H801 3.6 63.3 1.0 H091 D:V5H801 3.6 63.3 1.0 HD22 C:LEU669 3.6 47.1 1.0 C56 D:V5H801 3.7 63.3 1.0 H082 D:V5H801 3.7 63.3 1.0 C08 D:V5H801 3.8 63.3 1.0 H171 D:V5H801 3.9 63.3 1.0 H541 D:V5H801 3.9 63.3 1.0 H081 D:V5H801 4.1 63.3 1.0 H563 D:V5H801 4.2 63.3 1.0 C15 D:V5H801 4.2 63.3 1.0 HD13 D:ILE573 4.3 53.9 1.0 HD12 C:LEU669 4.4 47.1 1.0 CD2 C:LEU669 4.6 47.1 1.0 HD23 D:LEU515 4.6 59.2 1.0 H152 D:V5H801 4.7 63.3 1.0 H151 D:V5H801 4.7 63.3 1.0 C17 D:V5H801 4.8 63.3 1.0 C54 D:V5H801 4.9 63.3 1.0 HD23 C:LEU669 4.9 47.1 1.0 C16 D:V5H801 4.9 63.3 1.0 C55 D:V5H801 4.9 63.3 1.0 H162 D:V5H801 4.9 63.3 1.0 HD22 D:LEU515 5.0 59.2 1.0 O D:HOH912 5.0 75.2 1.0 HD21 C:LEU669 5.0 47.1 1.0

W.R.Arnold, M.Mancino, F.R.Moss Iii, A.Frost, D.Julius, Y.Cheng. Structural Basis of TRPV1 Modulation By Endogenous Bioactive Lipids Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01299-2