Bromine in PDB 8v86: ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107

The binding sites of Bromine atom in the ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107 (pdb code 8v86). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 5 binding sites of Bromine where determined in the ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107, PDB code: 8v86:
Jump to Bromine binding site number: 1; 2; 3; 4; 5;

Bromine binding site 1 out of 5 in the ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br504 b:63.7 occ:1.00 BR24 A:YLI504 0.0 63.7 1.0 C21 A:YLI504 1.9 63.7 1.0 H31H A:POV505 2.8 61.4 1.0 C22 A:YLI504 2.8 63.7 1.0 C20 A:YLI504 2.8 63.7 1.0 H20 A:YLI504 2.9 63.7 1.0 H22 A:YLI504 2.9 63.7 1.0 HD11 A:LEU224 3.1 49.0 1.0 H31G A:POV505 3.1 61.4 1.0 HD12 A:LEU224 3.2 49.0 1.0 HA3 E:GLY282 3.3 51.6 1.0 HD21 E:LEU246 3.3 49.2 1.0 HB3 A:LEU220 3.3 52.7 1.0 HD13 A:ILE221 3.4 51.8 1.0 C316 A:POV505 3.4 61.4 1.0 H314 A:POV505 3.4 61.4 1.0 HG A:LEU224 3.4 49.0 1.0 CD1 A:LEU224 3.5 49.0 1.0 HD11 E:LEU246 3.6 49.2 1.0 H31E A:POV505 3.8 61.4 1.0 HA2 E:GLY282 3.9 51.6 1.0 C314 A:POV505 4.0 61.4 1.0 CG A:LEU224 4.0 49.0 1.0 CA E:GLY282 4.0 51.6 1.0 HB2 A:LEU220 4.1 52.7 1.0 O A:LEU220 4.1 52.7 1.0 HD11 A:ILE221 4.1 51.8 1.0 H316 A:POV505 4.1 61.4 1.0 C23 A:YLI504 4.1 63.7 1.0 C19 A:YLI504 4.1 63.7 1.0 CB A:LEU220 4.1 52.7 1.0 CD1 A:ILE221 4.2 51.8 1.0 CD2 E:LEU246 4.2 49.2 1.0 HD22 E:LEU246 4.2 49.2 1.0 C315 A:POV505 4.3 61.4 1.0 HA A:ILE221 4.3 51.8 1.0 C A:LEU220 4.4 52.7 1.0 HD13 A:LEU224 4.4 49.0 1.0 CD1 E:LEU246 4.4 49.2 1.0 HD13 E:LEU246 4.5 49.2 1.0 HD13 A:LEU220 4.5 52.7 1.0 HD21 A:LEU224 4.5 49.0 1.0 O E:MET278 4.6 55.7 1.0 C18 A:YLI504 4.7 63.7 1.0 H E:GLY282 4.7 51.6 1.0 H315 A:POV505 4.8 61.4 1.0 HD12 A:ILE221 4.8 51.8 1.0 N A:ILE221 4.8 51.8 1.0 HG12 A:ILE221 4.8 51.8 1.0 N E:GLY282 4.8 51.6 1.0 HD23 E:LEU246 4.8 49.2 1.0 HB2 A:LEU224 4.9 49.0 1.0 H19 A:YLI504 4.9 63.7 1.0 H23 A:YLI504 4.9 63.7 1.0 CD2 A:LEU224 4.9 49.0 1.0 CA A:LEU220 4.9 52.7 1.0 CG E:LEU246 4.9 49.2 1.0 HA E:ILE279 4.9 56.6 1.0 H31F A:POV505 5.0 61.4 1.0

Bromine binding site 2 out of 5 in the ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107 within 5.0Å range: probe atom residue distance (Å) B Occ B:Br501 b:63.7 occ:1.00 BR24 B:YLI501 0.0 63.7 1.0 C21 B:YLI501 1.9 63.7 1.0 H31H B:POV502 2.8 61.4 1.0 C22 B:YLI501 2.8 63.7 1.0 C20 B:YLI501 2.8 63.7 1.0 H20 B:YLI501 2.9 63.7 1.0 H22 B:YLI501 2.9 63.7 1.0 HD11 B:LEU224 3.1 49.0 1.0 H31G B:POV502 3.1 61.4 1.0 HD12 B:LEU224 3.2 49.0 1.0 HA3 A:GLY282 3.3 51.6 1.0 HD21 A:LEU246 3.3 49.2 1.0 HB3 B:LEU220 3.3 52.7 1.0 HD13 B:ILE221 3.4 51.8 1.0 C316 B:POV502 3.4 61.4 1.0 H314 B:POV502 3.4 61.4 1.0 HG B:LEU224 3.4 49.0 1.0 CD1 B:LEU224 3.5 49.0 1.0 HD11 A:LEU246 3.6 49.2 1.0 H31E B:POV502 3.8 61.4 1.0 HA2 A:GLY282 3.9 51.6 1.0 C314 B:POV502 4.0 61.4 1.0 CG B:LEU224 4.0 49.0 1.0 CA A:GLY282 4.0 51.6 1.0 HB2 B:LEU220 4.1 52.7 1.0 O B:LEU220 4.1 52.7 1.0 HD11 B:ILE221 4.1 51.8 1.0 H316 B:POV502 4.1 61.4 1.0 C23 B:YLI501 4.1 63.7 1.0 C19 B:YLI501 4.1 63.7 1.0 CB B:LEU220 4.1 52.7 1.0 CD1 B:ILE221 4.2 51.8 1.0 CD2 A:LEU246 4.2 49.2 1.0 HD22 A:LEU246 4.2 49.2 1.0 C315 B:POV502 4.3 61.4 1.0 HA B:ILE221 4.3 51.8 1.0 C B:LEU220 4.4 52.7 1.0 HD13 B:LEU224 4.4 49.0 1.0 CD1 A:LEU246 4.4 49.2 1.0 HD13 A:LEU246 4.5 49.2 1.0 HD13 B:LEU220 4.5 52.7 1.0 HD21 B:LEU224 4.5 49.0 1.0 O A:MET278 4.6 55.7 1.0 C18 B:YLI501 4.7 63.7 1.0 H A:GLY282 4.7 51.6 1.0 H315 B:POV502 4.8 61.4 1.0 HD12 B:ILE221 4.8 51.8 1.0 N B:ILE221 4.8 51.8 1.0 HG12 B:ILE221 4.8 51.8 1.0 N A:GLY282 4.8 51.6 1.0 HD23 A:LEU246 4.8 49.2 1.0 HB2 B:LEU224 4.9 49.0 1.0 H19 B:YLI501 4.9 63.7 1.0 H23 B:YLI501 4.9 63.7 1.0 CA B:LEU220 4.9 52.7 1.0 CD2 B:LEU224 4.9 49.0 1.0 CG A:LEU246 4.9 49.2 1.0 HA A:ILE279 4.9 56.6 1.0 H31F B:POV502 5.0 61.4 1.0

Bromine binding site 3 out of 5 in the ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107 within 5.0Å range: probe atom residue distance (Å) B Occ C:Br501 b:63.7 occ:1.00 BR24 C:YLI501 0.0 63.7 1.0 C21 C:YLI501 1.9 63.7 1.0 H31H C:POV502 2.8 61.4 1.0 C20 C:YLI501 2.8 63.7 1.0 C22 C:YLI501 2.8 63.7 1.0 H20 C:YLI501 2.9 63.7 1.0 H22 C:YLI501 2.9 63.7 1.0 HD11 C:LEU224 3.1 49.0 1.0 H31G C:POV502 3.1 61.4 1.0 HD12 C:LEU224 3.2 49.0 1.0 HA3 B:GLY282 3.3 51.6 1.0 HD21 B:LEU246 3.3 49.2 1.0 HB3 C:LEU220 3.3 52.7 1.0 HD13 C:ILE221 3.4 51.8 1.0 C316 C:POV502 3.4 61.4 1.0 H314 C:POV502 3.4 61.4 1.0 HG C:LEU224 3.5 49.0 1.0 CD1 C:LEU224 3.5 49.0 1.0 HD11 B:LEU246 3.6 49.2 1.0 H31E C:POV502 3.8 61.4 1.0 HA2 B:GLY282 3.9 51.6 1.0 C314 C:POV502 4.0 61.4 1.0 CG C:LEU224 4.0 49.0 1.0 CA B:GLY282 4.0 51.6 1.0 HB2 C:LEU220 4.1 52.7 1.0 O C:LEU220 4.1 52.7 1.0 HD11 C:ILE221 4.1 51.8 1.0 H316 C:POV502 4.1 61.4 1.0 C19 C:YLI501 4.1 63.7 1.0 C23 C:YLI501 4.1 63.7 1.0 CB C:LEU220 4.1 52.7 1.0 CD1 C:ILE221 4.2 51.8 1.0 CD2 B:LEU246 4.2 49.2 1.0 HD22 B:LEU246 4.2 49.2 1.0 C315 C:POV502 4.3 61.4 1.0 HA C:ILE221 4.3 51.8 1.0 C C:LEU220 4.4 52.7 1.0 HD13 C:LEU224 4.4 49.0 1.0 CD1 B:LEU246 4.4 49.2 1.0 HD13 B:LEU246 4.5 49.2 1.0 HD13 C:LEU220 4.5 52.7 1.0 HD21 C:LEU224 4.5 49.0 1.0 O B:MET278 4.6 55.7 1.0 C18 C:YLI501 4.7 63.7 1.0 H B:GLY282 4.7 51.6 1.0 H315 C:POV502 4.8 61.4 1.0 HD12 C:ILE221 4.8 51.8 1.0 N C:ILE221 4.8 51.8 1.0 HG12 C:ILE221 4.8 51.8 1.0 N B:GLY282 4.8 51.6 1.0 HD23 B:LEU246 4.8 49.2 1.0 HB2 C:LEU224 4.9 49.0 1.0 H19 C:YLI501 4.9 63.7 1.0 H23 C:YLI501 4.9 63.7 1.0 CA C:LEU220 4.9 52.7 1.0 CD2 C:LEU224 4.9 49.0 1.0 CG B:LEU246 4.9 49.2 1.0 HA B:ILE279 4.9 56.6 1.0 H31F C:POV502 5.0 61.4 1.0

Bromine binding site 4 out of 5 in the ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107 within 5.0Å range: probe atom residue distance (Å) B Occ D:Br501 b:63.7 occ:1.00 BR24 D:YLI501 0.0 63.7 1.0 C21 D:YLI501 1.9 63.7 1.0 H31H D:POV502 2.8 61.4 1.0 C22 D:YLI501 2.8 63.7 1.0 C20 D:YLI501 2.8 63.7 1.0 H20 D:YLI501 2.9 63.7 1.0 H22 D:YLI501 2.9 63.7 1.0 HD11 D:LEU224 3.1 49.0 1.0 H31G D:POV502 3.1 61.4 1.0 HD12 D:LEU224 3.2 49.0 1.0 HA3 C:GLY282 3.3 51.6 1.0 HB3 D:LEU220 3.3 52.7 1.0 HD21 C:LEU246 3.3 49.2 1.0 HD13 D:ILE221 3.4 51.8 1.0 C316 D:POV502 3.4 61.4 1.0 H314 D:POV502 3.4 61.4 1.0 HG D:LEU224 3.4 49.0 1.0 CD1 D:LEU224 3.5 49.0 1.0 HD11 C:LEU246 3.6 49.2 1.0 H31E D:POV502 3.8 61.4 1.0 HA2 C:GLY282 3.9 51.6 1.0 C314 D:POV502 4.0 61.4 1.0 CG D:LEU224 4.0 49.0 1.0 CA C:GLY282 4.0 51.6 1.0 HB2 D:LEU220 4.1 52.7 1.0 O D:LEU220 4.1 52.7 1.0 HD11 D:ILE221 4.1 51.8 1.0 H316 D:POV502 4.1 61.4 1.0 CB D:LEU220 4.1 52.7 1.0 C23 D:YLI501 4.1 63.7 1.0 C19 D:YLI501 4.1 63.7 1.0 CD1 D:ILE221 4.2 51.8 1.0 CD2 C:LEU246 4.2 49.2 1.0 HD22 C:LEU246 4.2 49.2 1.0 C315 D:POV502 4.3 61.4 1.0 HA D:ILE221 4.3 51.8 1.0 C D:LEU220 4.4 52.7 1.0 HD13 D:LEU224 4.4 49.0 1.0 CD1 C:LEU246 4.4 49.2 1.0 HD13 C:LEU246 4.5 49.2 1.0 HD13 D:LEU220 4.5 52.7 1.0 HD21 D:LEU224 4.5 49.0 1.0 O C:MET278 4.6 55.7 1.0 C18 D:YLI501 4.7 63.7 1.0 H C:GLY282 4.7 51.6 1.0 H315 D:POV502 4.8 61.4 1.0 HD12 D:ILE221 4.8 51.8 1.0 N D:ILE221 4.8 51.8 1.0 HG12 D:ILE221 4.8 51.8 1.0 N C:GLY282 4.8 51.6 1.0 HD23 C:LEU246 4.8 49.2 1.0 HB2 D:LEU224 4.9 49.0 1.0 H19 D:YLI501 4.9 63.7 1.0 CA D:LEU220 4.9 52.7 1.0 H23 D:YLI501 4.9 63.7 1.0 CD2 D:LEU224 4.9 49.0 1.0 CG C:LEU246 4.9 49.2 1.0 HA C:ILE279 4.9 56.6 1.0 H31F D:POV502 5.0 61.4 1.0

Bromine binding site 5 out of 5 in the ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of ALPHA7-Nicotinic Acetylcholine Receptor Bound to GAT107 within 5.0Å range: probe atom residue distance (Å) B Occ E:Br501 b:63.7 occ:1.00 BR24 E:YLI501 0.0 63.7 1.0 C21 E:YLI501 1.9 63.7 1.0 H31H E:POV502 2.8 61.4 1.0 C22 E:YLI501 2.8 63.7 1.0 C20 E:YLI501 2.8 63.7 1.0 H20 E:YLI501 2.9 63.7 1.0 H22 E:YLI501 2.9 63.7 1.0 HD11 E:LEU224 3.1 49.0 1.0 H31G E:POV502 3.1 61.4 1.0 HD12 E:LEU224 3.2 49.0 1.0 HA3 D:GLY282 3.3 51.6 1.0 HD21 D:LEU246 3.3 49.2 1.0 HB3 E:LEU220 3.3 52.7 1.0 HD13 E:ILE221 3.3 51.8 1.0 C316 E:POV502 3.4 61.4 1.0 H314 E:POV502 3.4 61.4 1.0 HG E:LEU224 3.4 49.0 1.0 CD1 E:LEU224 3.5 49.0 1.0 HD11 D:LEU246 3.6 49.2 1.0 H31E E:POV502 3.8 61.4 1.0 HA2 D:GLY282 3.9 51.6 1.0 C314 E:POV502 4.0 61.4 1.0 CG E:LEU224 4.0 49.0 1.0 CA D:GLY282 4.0 51.6 1.0 HB2 E:LEU220 4.1 52.7 1.0 O E:LEU220 4.1 52.7 1.0 HD11 E:ILE221 4.1 51.8 1.0 H316 E:POV502 4.1 61.4 1.0 C23 E:YLI501 4.1 63.7 1.0 CB E:LEU220 4.1 52.7 1.0 C19 E:YLI501 4.1 63.7 1.0 CD1 E:ILE221 4.2 51.8 1.0 CD2 D:LEU246 4.2 49.2 1.0 HD22 D:LEU246 4.2 49.2 1.0 C315 E:POV502 4.3 61.4 1.0 HA E:ILE221 4.3 51.8 1.0 C E:LEU220 4.4 52.7 1.0 HD13 E:LEU224 4.4 49.0 1.0 CD1 D:LEU246 4.4 49.2 1.0 HD13 D:LEU246 4.5 49.2 1.0 HD13 E:LEU220 4.5 52.7 1.0 HD21 E:LEU224 4.5 49.0 1.0 O D:MET278 4.6 55.7 1.0 C18 E:YLI501 4.7 63.7 1.0 H D:GLY282 4.7 51.6 1.0 H315 E:POV502 4.8 61.4 1.0 HD12 E:ILE221 4.8 51.8 1.0 N E:ILE221 4.8 51.8 1.0 HG12 E:ILE221 4.8 51.8 1.0 N D:GLY282 4.8 51.6 1.0 HD23 D:LEU246 4.8 49.2 1.0 HB2 E:LEU224 4.9 49.0 1.0 H19 E:YLI501 4.9 63.7 1.0 CA E:LEU220 4.9 52.7 1.0 H23 E:YLI501 4.9 63.7 1.0 CD2 E:LEU224 4.9 49.0 1.0 CG D:LEU246 4.9 49.2 1.0 HA D:ILE279 4.9 56.6 1.0 H31F E:POV502 5.0 61.4 1.0

S.M.Burke, M.Avstrikova, C.M.Noviello, N.Mukhtasimova, J.P.Changeux, G.A.Thakur, S.M.Sine, M.Cecchini, R.E.Hibbs. Structural Mechanisms of ALPHA7 Nicotinic Receptor Allosteric Modulation and Activation To Be Published.