Bromine in PDB 9c7a: Crystal Structure of R149W Neurodevelopmental Disease-Associated U2AF2 Variant

The structure of Crystal Structure of R149W Neurodevelopmental Disease-Associated U2AF2 Variant, PDB code: 9c7a was solved by D.Maji, J.L.Jenkins, C.L.Kielkopf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.78 / 1.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	43.25, 63.131, 77.559, 90, 90, 90
R / Rfree (%)	13 / 15.9

The structure of Crystal Structure of R149W Neurodevelopmental Disease-Associated U2AF2 Variant also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Bromine atom in the Crystal Structure of R149W Neurodevelopmental Disease-Associated U2AF2 Variant (pdb code 9c7a). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of R149W Neurodevelopmental Disease-Associated U2AF2 Variant, PDB code: 9c7a:

Bromine binding site 1 out of 1 in the Crystal Structure of R149W Neurodevelopmental Disease-Associated U2AF2 Variant


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of R149W Neurodevelopmental Disease-Associated U2AF2 Variant within 5.0Å range: probe atom residue distance (Å) B Occ B:Br7 b:13.2 occ:1.00 BR B:BRU7 0.0 13.2 1.0 C5 B:BRU7 1.9 14.2 1.0 C6 B:BRU7 2.9 14.4 1.0 C4 B:BRU7 2.9 13.7 1.0 OP2 B:U6 3.0 13.9 1.0 O4 B:BRU7 3.1 13.8 1.0 O5' B:U6 3.4 13.2 1.0 H3' B:U6 3.5 17.2 1.0 HG3 A:ARG227 3.7 13.8 1.0 P B:U6 3.7 13.2 1.0 O B:HOH126 3.8 15.0 1.0 HE1 A:HIS230 3.8 19.4 1.0 HH A:TYR152 3.8 18.7 1.0 CZ A:TYR152 3.8 14.0 1.0 CE1 A:TYR152 3.9 13.1 1.0 HE2 A:HIS230 3.9 19.8 1.0 OH A:TYR152 4.0 15.6 1.0 HE1 A:TYR152 4.0 15.8 1.0 O B:HOH115 4.1 16.4 1.0 N1 B:BRU7 4.1 13.9 1.0 H2' B:U6 4.1 18.7 1.0 N3 B:BRU7 4.2 13.2 1.0 O B:HOH110 4.2 14.3 1.0 CE1 A:HIS230 4.3 16.1 1.0 CE2 A:TYR152 4.3 14.4 1.0 NE2 A:HIS230 4.3 16.5 1.0 C3' B:U6 4.4 14.3 1.0 CD1 A:TYR152 4.4 12.1 1.0 H5'' B:U6 4.4 17.0 1.0 C5' B:U6 4.4 14.2 1.0 OP1 B:U6 4.5 15.1 1.0 HE2 A:TYR152 4.6 17.3 1.0 CG A:ARG227 4.6 11.5 1.0 C2 B:BRU7 4.7 14.2 1.0 O B:HOH108 4.7 21.8 1.0 C2' B:U6 4.7 15.6 1.0 HB2 A:ARG227 4.7 15.7 1.0 CD2 A:TYR152 4.7 13.9 1.0 HO2' B:U6 4.8 21.3 1.0 HD1 A:TYR152 4.8 14.5 1.0 CG A:TYR152 4.8 12.4 1.0 O5' B:BRU7 4.9 16.8 1.0

D.Maji, J.L.Jenkins, P.L.Boutz, C.L.Kielkopf. Recurrent Neurodevelopmentally-Associated Variants of the Pre-Mrna Splicing Factor U2AF2 Alter Rna Binding Affinities and Interactions To Be Published.