Bromine in the structure of Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Brodimoprim-4,6-Dicarboxylate (pdb 1dis)

The binding sites of Bromine atom in the structure of Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Brodimoprim-4,6-Dicarboxylate (pdb code 1dis). This binding sites where shown with 5.0 Angstroms radius around Bromine atom. The 1dis structure was solved by W.D.MORGAN, B.BIRDSALL, V.I.POLSHAKOV, D.SALI, I.KOMPIS, J.FEENEY, with NMR in Solution technique. Bromine Binding Sites: Bromine binding site 1 out of 1 in 1dis Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Bromine in the PDB 1dis. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Bromine atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Leu19, A: Leu27, A: Ser48, A: Phe49, A: Pro50, A: Bdm163, conact list: Atom Atom Distance (A) Br HD13 A:Leu19 4.73 Br HD12 A:Leu19 4.91 Br HD21 A:Leu27 3.31 Br HD22 A:Leu27 3.40 Br CD2 A:Leu27 3.89 Br HG A:Leu27 4.84 Br HD23 A:Leu27 4.48 Br O A:Ser48 4.50 Br CB A:Phe49 4.94 Br HB3 A:Phe49 4.72 Br CD1 A:Phe49 4.28 Br HD1 A:Phe49 3.23 Br C A:Phe49 4.81 Br CA A:Phe49 4.32 Br HA A:Phe49 3.23 Br HE1 A:Phe49 4.94 Br N A:Pro50 4.31 Br HG3 A:Pro50 4.15 Br CD A:Pro50 2.99 Br CG A:Pro50 3.77 Br HD2 A:Pro50 2.60 Br HG2 A:Pro50 3.54 Br HD3 A:Pro50 2.49 Br BR11 A:Bdm163 0.00 Br C11 A:Bdm163 1.92 Br H151 A:Bdm163 4.77 Br C8 A:Bdm163 4.70 Br C16 A:Bdm163 4.46 Br O10 A:Bdm163 2.97 Br C13 A:Bdm163 4.17 Br C10 A:Bdm163 2.89 Br H161 A:Bdm163 4.04 Br O12 A:Bdm163 3.04 Br H142 A:Bdm163 4.36 Br C9 A:Bdm163 4.20 Br C12 A:Bdm163 2.86 Br H162 A:Bdm163 4.24 Br C14 A:Bdm163 3.85 Br H141 A:Bdm163 4.77 Br C15 A:Bdm163 4.27 Br H143 A:Bdm163 3.60 interactive model: