Bromine in PDB 1diu: Dihydrofolate Reductase (E.C.1.5.1.3) Complex with Brodimoprim-4,6-Dicarboxylate

All present enzymatic activity of Dihydrofolate Reductase (E.C.1.5.1.3) Complex with Brodimoprim-4,6-Dicarboxylate:
1.5.1.3;

The binding sites of Bromine atom in the Dihydrofolate Reductase (E.C.1.5.1.3) Complex with Brodimoprim-4,6-Dicarboxylate (pdb code 1diu). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Dihydrofolate Reductase (E.C.1.5.1.3) Complex with Brodimoprim-4,6-Dicarboxylate, PDB code: 1diu:

Bromine binding site 1 out of 1 in the Dihydrofolate Reductase (E.C.1.5.1.3) Complex with Brodimoprim-4,6-Dicarboxylate


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Dihydrofolate Reductase (E.C.1.5.1.3) Complex with Brodimoprim-4,6-Dicarboxylate within 5.0Å range: probe atom residue distance (Å) B Occ A:Br163 b:0.0 occ:1.00 BR11 A:BDM163 0.0 0.0 1.0 C11 A:BDM163 1.9 0.0 1.0 HD3 A:PRO50 2.4 0.0 1.0 HD2 A:PRO50 2.7 0.0 1.0 C12 A:BDM163 2.9 0.0 1.0 C10 A:BDM163 2.9 0.0 1.0 O10 A:BDM163 2.9 0.0 1.0 CD A:PRO50 3.0 0.0 1.0 O12 A:BDM163 3.0 0.0 1.0 HA A:PHE49 3.2 0.0 1.0 H141 A:BDM163 3.3 0.0 1.0 HD1 A:PHE49 3.4 0.0 1.0 HD22 A:LEU27 3.5 0.0 1.0 HG2 A:PRO50 3.6 0.0 1.0 HD21 A:LEU27 3.7 0.0 1.0 C14 A:BDM163 3.7 0.0 1.0 CG A:PRO50 3.8 0.0 1.0 CD2 A:LEU27 4.0 0.0 1.0 H162 A:BDM163 4.0 0.0 1.0 HD13 A:LEU19 4.0 0.0 1.0 HD23 A:LEU27 4.1 0.0 1.0 HG3 A:PRO50 4.1 0.0 1.0 C13 A:BDM163 4.2 0.0 1.0 C9 A:BDM163 4.2 0.0 1.0 CA A:PHE49 4.2 0.0 1.0 H143 A:BDM163 4.3 0.0 1.0 C15 A:BDM163 4.3 0.0 1.0 N A:PRO50 4.3 0.0 1.0 O A:SER48 4.3 0.0 1.0 CD1 A:PHE49 4.3 0.0 1.0 HD12 A:LEU19 4.5 0.0 1.0 H142 A:BDM163 4.6 0.0 1.0 C16 A:BDM163 4.6 0.0 1.0 C8 A:BDM163 4.7 0.0 1.0 C A:PHE49 4.8 0.0 1.0 H151 A:BDM163 4.8 0.0 1.0 CD1 A:LEU19 4.8 0.0 1.0 H161 A:BDM163 4.9 0.0 1.0 HB3 A:PHE49 4.9 0.0 1.0 HE1 A:PHE49 4.9 0.0 1.0 H152 A:BDM163 5.0 0.0 1.0 CB A:PHE49 5.0 0.0 1.0

W.D.Morgan, B.Birdsall, V.I.Polshakov, D.Sali, I.Kompis, J.Feeney. Solution Structure of A Brodimoprim Analogue in Its Complex with Lactobacillus Casei Dihydrofolate Reductase. Biochemistry V. 34 11690 1995.
ISSN: ISSN 0006-2960
PubMed: 7547901
DOI: 10.1021/BI00037A006