Bromine in PDB 1vp6: M.Loti Ion Channel Cylic Nucleotide Binding Domain

The structure of M.Loti Ion Channel Cylic Nucleotide Binding Domain, PDB code: 1vp6 was solved by G.M.Clayton, W.R.Silverman, L.Heginbotham, J.H.Morais-Cabral, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.89 / 1.70
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	34.324, 80.292, 50.419, 90.00, 99.16, 90.00
R / Rfree (%)	19 / 21.9

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 16;

Binding sites:

The binding sites of Bromine atom in the M.Loti Ion Channel Cylic Nucleotide Binding Domain (pdb code 1vp6). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 16 binding sites of Bromine where determined in the M.Loti Ion Channel Cylic Nucleotide Binding Domain, PDB code: 1vp6:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Bromine binding site 1 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br356 b:20.6 occ:0.89 O A:HOH435 3.1 46.2 1.0 N A:GLY278 3.2 14.3 1.0 CA A:GLY278 3.8 11.7 1.0 CG A:PRO292 4.0 9.0 1.0 CG A:GLU277 4.0 29.0 1.0 C A:GLU277 4.3 15.3 1.0 CA A:GLU277 4.4 15.1 1.0 O A:GLY278 4.5 10.2 1.0 C A:GLY278 4.6 12.1 1.0 CD A:PRO292 4.7 9.3 1.0 CB A:GLU277 4.8 19.9 1.0

Bromine binding site 2 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br357 b:85.4 occ:0.82 O A:HOH441 2.8 16.0 1.0 OG A:SER321 3.1 27.7 1.0 NH1 A:ARG271 3.4 33.4 1.0 NE2 A:HIS323 3.4 37.0 1.0 NE A:ARG252 3.5 47.9 1.0 CB A:ARG252 3.8 20.3 1.0 CG A:ARG252 4.0 30.8 1.0 NH2 A:ARG252 4.1 49.1 1.0 CB A:SER321 4.1 19.5 1.0 CZ A:ARG252 4.2 51.0 1.0 CE1 A:HIS323 4.3 33.2 1.0 CD A:ARG252 4.3 38.8 1.0 CZ A:ARG271 4.4 30.8 1.0 CD2 A:HIS323 4.5 32.2 1.0 CD A:ARG271 4.8 20.9 1.0 NE A:ARG271 5.0 29.9 1.0

Bromine binding site 3 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br358 b:31.5 occ:0.56 O A:HOH379 2.8 22.9 1.0 O A:HOH382 3.2 13.9 0.9 NH2 A:ARG307 3.4 9.6 1.0 CZ A:PHE273 3.7 12.5 1.0 O A:ILE262 3.8 14.8 1.0 CE1 A:PHE273 4.1 14.7 1.0 CB A:CYS263 4.2 20.6 1.0 CG A:ARG271 4.2 19.3 1.0 O A:HOH492 4.2 30.5 0.8 CD A:ARG271 4.2 20.9 1.0 CZ A:ARG307 4.3 7.5 1.0 NE A:ARG307 4.4 11.3 1.0 O A:HOH450 4.5 15.6 0.9 CA A:CYS263 4.6 15.3 1.0 NE A:ARG271 4.7 29.9 1.0 C A:ILE262 4.8 12.4 1.0 CE2 A:PHE273 4.9 17.7 1.0

Bromine binding site 4 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br359 b:39.6 occ:0.47 O A:HOH421 3.3 30.5 1.0 CB A:ALA260 3.7 9.3 1.0 CD A:PRO257 3.9 14.0 1.0 CG A:PRO257 4.2 13.0 1.0 CG1 A:VAL256 4.6 9.2 1.0 NH2 A:ARG254 4.8 38.8 1.0

Bromine binding site 5 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br360 b:29.1 occ:0.67 O A:HOH378 3.7 16.1 0.9 CA A:GLY259 3.7 9.6 1.0 N A:GLY259 4.0 7.0 1.0 O A:ALA258 4.1 9.9 1.0 C A:ALA258 4.1 10.4 1.0 CB A:ALA258 4.6 11.2 1.0

Bromine binding site 6 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 6 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br361 b:31.5 occ:0.77 O A:HOH385 3.0 20.6 1.0 O A:HOH390 3.6 17.0 1.0 OG1 A:THR310 4.1 9.8 1.0 CG2 A:ILE265 4.3 13.8 1.0 CB A:THR310 4.5 12.7 1.0 CB A:ALA283 4.7 9.4 1.0 O A:HOH446 4.7 28.8 1.0

Bromine binding site 7 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 7 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br362 b:30.3 occ:0.55 O A:HOH456 2.8 36.7 1.0 NH2 A:ARG264 3.3 23.6 1.0 CZ A:ARG264 4.7 17.9 1.0

Bromine binding site 8 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 8 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br363 b:23.9 occ:0.89 NH2 A:ARG349 2.9 54.7 1.0 CZ A:ARG349 3.1 51.3 1.0 NE A:ARG349 3.2 50.6 1.0 O A:HOH405 3.7 29.5 1.0 CB A:SER303 3.9 14.3 1.0 NH1 A:ARG349 4.0 54.5 1.0 CB A:ALA345 4.0 19.9 1.0 O A:MET299 4.0 11.8 1.0 CG A:MET299 4.0 15.0 1.0 CB A:MET299 4.0 10.2 1.0 CA A:MET299 4.2 10.8 1.0 CD A:ARG349 4.2 46.8 1.0 OG A:SER303 4.2 15.3 1.0 CE A:MET299 4.2 18.7 1.0 O A:ALA345 4.3 21.2 1.0 CB A:ARG349 4.4 33.6 1.0 CG2 A:ILE302 4.4 14.9 1.0 C A:ALA345 4.5 22.1 1.0 C A:MET299 4.5 8.0 1.0 CB A:ILE302 4.6 11.3 1.0 N A:SER303 4.6 12.4 1.0 CA A:ALA345 4.7 19.9 1.0 CA A:SER303 4.8 11.9 1.0 CG A:ARG349 4.8 39.7 1.0 SD A:MET299 5.0 16.7 1.0

Bromine binding site 9 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 9 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br364 b:35.7 occ:0.64 O A:HOH432 2.9 51.3 0.8 O A:HOH451 3.0 18.9 1.0 O A:HOH380 3.3 16.1 1.0 CG1 C:VAL224 3.6 25.2 1.0 CA A:ALA231 3.6 12.2 1.0 NH2 C:ARG220 3.7 26.0 1.0 CB A:ALA231 3.9 13.6 1.0 O C:HOH438 3.9 29.2 1.0 N A:ALA231 4.2 10.7 1.0 O A:HOH414 4.2 19.3 1.0 O A:HOH486 4.2 30.2 0.8 NH1 C:ARG220 4.2 24.5 1.0 CG2 C:VAL224 4.2 21.0 1.0 CZ C:ARG220 4.5 20.2 1.0 O C:HOH411 4.5 28.1 1.0 O A:VAL230 4.5 11.0 1.0 CB C:VAL224 4.5 19.4 1.0 C A:VAL230 4.6 11.9 1.0 CG1 A:VAL230 4.6 15.6 1.0 C A:ALA231 4.7 13.7 1.0 O A:ALA231 4.9 14.8 1.0 O A:TRP227 4.9 17.0 1.0

Bromine binding site 10 out of 16 in the M.Loti Ion Channel Cylic Nucleotide Binding Domain


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 10 of M.Loti Ion Channel Cylic Nucleotide Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Br365 b:40.6 occ:0.72 O A:HOH377 3.4 21.5 1.0 N A:ALA242 3.5 15.8 1.0 C A:GLY240 3.5 18.8 1.0 CA A:GLY240 3.5 18.6 1.0 CB A:ALA242 3.6 17.1 1.0 N A:VAL243 3.6 17.5 1.0 CG2 A:VAL243 3.7 18.4 1.0 O A:GLY240 3.8 17.8 1.0 N A:PRO241 3.9 13.9 1.0 CA A:ALA242 3.9 16.1 1.0 N A:GLY240 4.0 20.0 1.0 O C:HOH401 4.0 38.1 1.0 C A:ALA242 4.3 16.6 1.0 CD A:PRO241 4.3 19.1 1.0 C A:PRO241 4.3 14.2 1.0 CB A:VAL243 4.4 16.1 1.0 CA A:VAL243 4.6 14.7 1.0 CA A:PRO241 4.6 16.4 1.0

G.M.Clayton, W.R.Silverman, L.Heginbotham, J.H.Morais-Cabral. Structural Basis of Ligand Activation in A Cyclic Nucleotide Regulated Potassium Channel. Cell(Cambridge,Mass.) V. 119 615 2004.
ISSN: ISSN 0092-8674
PubMed: 15550244
DOI: 10.1016/J.CELL.2004.10.030