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Bromine in PDB 1z4u: Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585

Enzymatic activity of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585

All present enzymatic activity of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585:
2.7.7.48;

Protein crystallography data

The structure of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585, PDB code: 1z4u was solved by J.A.Pfefferkorn, M.Greene, R.Nugent, R.J.Gross, M.A.Mitchell, B.C.Finzel, M.S.Harris, P.A.Wells, J.A.Shelly, R.Anstadt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.80
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 91.344, 91.344, 189.111, 90.00, 90.00, 120.00
R / Rfree (%) 20.8 / 26.5

Other elements in 1z4u:

The structure of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Bromine Binding Sites:

The binding sites of Bromine atom in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 (pdb code 1z4u). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585, PDB code: 1z4u:

Bromine binding site 1 out of 1 in 1z4u

Go back to Bromine Binding Sites List in 1z4u
Bromine binding site 1 out of 1 in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br600

b:74.2
occ:1.00
 BRA2 A:PH9600 0.0 74.2 1.0
CA2 A:PH9600 1.9 65.4 1.0
CA1 A:PH9600 2.9 61.5 1.0
CA3 A:PH9600 2.9 66.9 1.0
OAB A:PH9600 3.0 55.9 1.0
OH A:TYR448 3.3 65.4 1.0
O A:HOH731 3.6 52.9 1.0
CE A:MET414 3.7 65.3 1.0
CB6 A:PH9600 3.8 52.5 1.0
N A:PRO197 3.8 59.4 1.0
CA A:PRO197 3.8 61.2 1.0
CD A:ARG200 3.9 57.5 1.0
O A:TYR195 3.9 56.2 1.0
CB A:ARG200 4.1 62.7 1.0
C A:SER196 4.1 59.2 1.0
CG A:PRO197 4.2 60.4 1.0
CD A:PRO197 4.2 59.7 1.0
O A:SER196 4.2 59.9 1.0
CA6 A:PH9600 4.2 60.3 1.0
CA4 A:PH9600 4.3 64.8 1.0
CB5 A:PH9600 4.3 51.0 1.0
CZ A:TYR448 4.4 63.9 1.0
CE2 A:TYR448 4.5 62.5 1.0
CG A:ARG200 4.5 60.1 1.0
CB4 A:PH9600 4.5 51.1 1.0
CB A:PRO197 4.6 60.3 1.0
C A:TYR195 4.8 56.4 1.0
CA A:SER196 4.8 58.8 1.0
CA5 A:PH9600 4.8 62.0 1.0
SD A:MET414 4.9 67.8 1.0
C A:PRO197 5.0 63.2 1.0

Reference:

J.A.Pfefferkorn, R.Nugent, R.J.Gross, M.Greene, M.A.Mitchell, M.T.Reding, L.A.Funk, R.Anderson, P.A.Wells, J.A.Shelly, R.Anstadt, B.C.Finzel, M.S.Harris, R.E.Kilkuskie, L.A.Kopta, F.J.Schwende. Inhibitors of Hcv NS5B Polymerase. Part 2: Evaluation of the Northern Region of (2Z)-2-Benzoylamino-3-(4-Phenoxy-Phenyl)-Acrylic Acid Bioorg.Med.Chem.Lett. V. 15 2812 2005.
ISSN: ISSN 0960-894X
PubMed: 15911260
DOI: 10.1016/J.BMCL.2005.03.106
Page generated: Wed Jul 10 17:38:16 2024

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