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Atomistry » Bromine » PDB 1uhj-1z5m » 1z5m | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 1uhj-1z5m » 1z5m » |
Bromine in PDB 1z5m: Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1Enzymatic activity of Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1
All present enzymatic activity of Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1:
2.7.1.37; Protein crystallography data
The structure of Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1, PDB code: 1z5m
was solved by
M.Whitlow,
M.Adler,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1z5m:
The structure of Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1 also contains other interesting chemical elements:
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1
(pdb code 1z5m). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1, PDB code: 1z5m: Bromine binding site 1 out of 1 in 1z5mGo back to Bromine Binding Sites List in 1z5m
Bromine binding site 1 out
of 1 in the Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1
Mono view Stereo pair view
Reference:
R.I.Feldman,
J.M.Wu,
M.A.Polokoff,
M.J.Kochanny,
H.Dinter,
D.Zhu,
S.L.Biroc,
B.Alicke,
J.Bryant,
S.Yuan,
B.O.Buckman,
D.Lentz,
M.Ferrer,
M.Whitlow,
M.Adler,
S.Finster,
Z.Chang,
D.O.Arnaiz.
Novel Small Molecule Inhibitors of 3-Phosphoinositide-Dependent Kinase-1. J.Biol.Chem. V. 280 19867 2005.
Page generated: Wed Jul 10 17:38:19 2024
ISSN: ISSN 0021-9258 PubMed: 15772071 DOI: 10.1074/JBC.M501367200 |
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