Bromine in PDB 2ga2: H-METAP2 Complexed with A193400

All present enzymatic activity of H-METAP2 Complexed with A193400:
3.4.11.18;

The structure of H-METAP2 Complexed with A193400, PDB code: 2ga2 was solved by C.Park, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.79 / 1.95
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	89.731, 98.793, 101.213, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The structure of H-METAP2 Complexed with A193400 also contains other interesting chemical elements:

Manganese	(Mn)	2 atoms
Chlorine	(Cl)	1 atom

The binding sites of Bromine atom in the H-METAP2 Complexed with A193400 (pdb code 2ga2). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the H-METAP2 Complexed with A193400, PDB code: 2ga2:

Bromine binding site 1 out of 1 in the H-METAP2 Complexed with A193400


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of H-METAP2 Complexed with A193400 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br482 b:45.0 occ:1.00 BR18 A:A19482 0.0 45.0 1.0 C15 A:A19482 1.9 44.8 1.0 C16 A:A19482 2.8 44.7 1.0 C14 A:A19482 2.9 44.9 1.0 CB A:ALA414 3.8 15.9 1.0 CG A:TYR444 3.9 18.2 1.0 CD2 A:TYR444 4.1 18.2 1.0 C17 A:A19482 4.2 44.7 1.0 CB A:TYR444 4.2 17.9 1.0 C13 A:A19482 4.2 44.9 1.0 CD1 A:TYR444 4.3 18.2 1.0 O A:HOH650 4.3 43.8 1.0 NE2 A:HIS231 4.4 17.3 1.0 CE1 A:HIS231 4.4 17.1 1.0 ND1 A:HIS382 4.4 19.1 1.0 CE2 A:TYR444 4.6 18.4 1.0 CB A:HIS382 4.6 18.9 1.0 C12 A:A19482 4.7 44.9 1.0 CE1 A:TYR444 4.7 18.2 1.0 SD A:MET384 4.8 18.8 1.0 CZ A:TYR444 4.9 18.5 1.0 CD2 A:HIS231 4.9 17.2 1.0 ND1 A:HIS231 4.9 17.2 1.0

M.Kawai, N.Y.Bamaung, S.D.Fidanze, S.A.Erickson, J.S.Tedrow, W.J.Sanders, A.Vasudevan, C.Park, C.Hutchins, K.M.Comess, D.Kalvin, J.Wang, Q.Zhang, P.Lou, L.Tucker-Garcia, J.Bouska, R.L.Bell, R.Lesniewski, J.Henkin, G.S.Sheppard. Development of Sulfonamide Compounds As Potent Methionine Aminopeptidase Type II Inhibitors with Antiproliferative Properties. Bioorg.Med.Chem.Lett. V. 16 3574 2006.
ISSN: ISSN 0960-894X
PubMed: 16632353
DOI: 10.1016/J.BMCL.2006.03.085