Bromine in PDB 2ja7: Cpd Lesion Containing Rna Polymerase II Elongation Complex C

All present enzymatic activity of Cpd Lesion Containing Rna Polymerase II Elongation Complex C:
2.7.7.6;

The structure of Cpd Lesion Containing Rna Polymerase II Elongation Complex C, PDB code: 2ja7 was solved by F.Brueckner, U.Hennecke, T.Carell, P.Cramer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50 / 3.8
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	394.358, 221.862, 283.105, 90.00, 90.56, 90.00
R / Rfree (%)	25.74 / 27.47

The structure of Cpd Lesion Containing Rna Polymerase II Elongation Complex C also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Zinc	(Zn)	16 atoms

The binding sites of Bromine atom in the Cpd Lesion Containing Rna Polymerase II Elongation Complex C (pdb code 2ja7). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Cpd Lesion Containing Rna Polymerase II Elongation Complex C, PDB code: 2ja7:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in the Cpd Lesion Containing Rna Polymerase II Elongation Complex C


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Cpd Lesion Containing Rna Polymerase II Elongation Complex C within 5.0Å range: probe atom residue distance (Å) B Occ 2:Br22 b:69.4 occ:1.00 BR 2:BRU22 0.0 69.4 1.0 C5 2:BRU22 1.9 73.2 1.0 C6 2:BRU22 2.8 73.7 1.0 C4 2:BRU22 2.9 74.0 1.0 O4 2:BRU22 3.2 75.5 1.0 C6 2:DC21 3.2 84.8 1.0 C5 2:DC21 3.4 85.4 1.0 N1 2:DC21 3.7 83.7 1.0 C2' 2:DC21 3.7 82.2 1.0 C4 2:DC21 3.9 86.0 1.0 N1 2:BRU22 4.1 74.5 1.0 N3 2:BRU22 4.1 75.7 1.0 C2 2:DC21 4.2 84.5 1.0 C1' 2:DC21 4.2 83.0 1.0 OP1 2:BRU22 4.3 78.1 1.0 N3 2:DC21 4.3 85.2 1.0 C3' 2:DC21 4.5 81.2 1.0 N4 2:DC21 4.6 88.5 1.0 C2 2:BRU22 4.7 75.2 1.0 O5' 2:BRU22 4.8 78.4 1.0

Bromine binding site 2 out of 2 in the Cpd Lesion Containing Rna Polymerase II Elongation Complex C


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Cpd Lesion Containing Rna Polymerase II Elongation Complex C within 5.0Å range: probe atom residue distance (Å) B Occ 5:Br22 b:77.6 occ:1.00 BR 5:BRU22 0.0 77.6 1.0 C5 5:BRU22 1.9 81.4 1.0 C4 5:BRU22 2.9 82.6 1.0 C6 5:BRU22 2.9 81.7 1.0 O4 5:BRU22 3.1 84.5 1.0 C6 5:DC21 3.2 93.7 1.0 C5 5:DC21 3.3 94.2 1.0 N1 5:DC21 3.6 92.7 1.0 C2' 5:DC21 3.8 90.4 1.0 C4 5:DC21 3.8 94.8 1.0 N3 5:BRU22 4.1 83.8 1.0 C2 5:DC21 4.1 93.7 1.0 N1 5:BRU22 4.2 82.1 1.0 N3 5:DC21 4.2 94.2 1.0 C1' 5:DC21 4.3 91.2 1.0 OP1 5:BRU22 4.5 86.7 1.0 N4 5:DC21 4.5 97.2 1.0 C3' 5:DC21 4.6 88.3 1.0 C2 5:BRU22 4.7 83.0 1.0 O2 5:DC21 5.0 93.9 1.0

F.Brueckner, U.Hennecke, T.Carell, P.Cramer. Cpd Damage Recognition By Transcribing Rna Polymerase II. Science V. 315 859 2007.
ISSN: ISSN 0036-8075
PubMed: 17290000
DOI: 10.1126/SCIENCE.1135400