Bromine in PDB 2obj: Crystal Structure of Human Pim-1 Kinase in Complex with Inhibitor

All present enzymatic activity of Crystal Structure of Human Pim-1 Kinase in Complex with Inhibitor:
2.7.11.1;

The structure of Crystal Structure of Human Pim-1 Kinase in Complex with Inhibitor, PDB code: 2obj was solved by N.Yao, I.W.Cheney, S.Yan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	500.00 / 2.50
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	97.264, 97.264, 80.827, 90.00, 90.00, 120.00
R / Rfree (%)	20.5 / 24.6

The binding sites of Bromine atom in the Crystal Structure of Human Pim-1 Kinase in Complex with Inhibitor (pdb code 2obj). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of Human Pim-1 Kinase in Complex with Inhibitor, PDB code: 2obj:

Bromine binding site 1 out of 1 in the Crystal Structure of Human Pim-1 Kinase in Complex with Inhibitor


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of Human Pim-1 Kinase in Complex with Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Br400 b:98.4 occ:1.00 BR23 A:VRV400 0.0 98.4 1.0 C6 A:VRV400 1.9 83.6 1.0 C5 A:VRV400 2.9 80.0 1.0 C1 A:VRV400 2.9 81.6 1.0 CD2 A:LEU174 4.0 33.7 1.0 CD1 A:LEU44 4.0 57.9 1.0 CG A:ARG122 4.1 48.7 1.0 CD A:ARG122 4.1 49.8 1.0 C2 A:VRV400 4.2 78.4 1.0 C4 A:VRV400 4.2 75.6 1.0 CG1 A:VAL126 4.4 44.7 1.0 CG A:LEU174 4.6 37.9 1.0 C3 A:VRV400 4.7 77.1 1.0 CB A:ALA65 4.9 43.1 1.0 CD2 A:LEU44 4.9 59.1 1.0 CB A:ARG122 4.9 49.9 1.0 CD1 A:LEU174 4.9 35.0 1.0

I.W.Cheney, S.Yan, T.Appleby, H.Walker, T.Vo, N.Yao, R.Hamatake, Z.Hong, J.Z.Wu. Identification and Structure-Activity Relationships of Substituted Pyridones As Inhibitors of Pim-1 Kinase. Bioorg.Med.Chem.Lett. V. 17 1679 2007.
ISSN: ISSN 0960-894X
PubMed: 17251021
DOI: 10.1016/J.BMCL.2006.12.086