Bromine in PDB 2pfh: Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Less Than Concentration of IDD594.

Enzymatic activity of Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Less Than Concentration of IDD594.

Protein crystallography data

Other elements in 2pfh:

Bromine Binding Sites:

Bromine binding site 1 out of 1 in 2pfh

Bromine Binding Sites List in 2pfh

Bromine binding site 1 out of 1 in the Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Less Than Concentration of IDD594.


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Less Than Concentration of IDD594. within 5.0Å range: probe atom residue distance (Å) B Occ A:Br320 b:4.6 occ:0.76 BR8 A:LDT320 0.0 4.6 0.8 CD2 A:LEU300 0.9 6.5 0.2 C25 A:LDT320 1.9 4.3 0.8 CG A:LEU300 2.4 6.8 0.2 C28 A:LDT320 2.8 4.3 0.8 OG1 A:THR113 2.8 4.7 1.0 C29 A:LDT320 2.9 4.0 0.8 CD1 A:LEU300 3.1 8.9 0.2 CB A:LEU300 3.5 6.9 0.2 SG A:CYS303 3.8 9.2 0.2 CB A:CYS303 3.9 7.2 0.2 CE3 A:TRP111 3.9 4.1 1.0 CZ A:PHE115 3.9 5.0 1.0 CB A:TRP111 4.0 4.0 1.0 CB A:THR113 4.0 4.6 1.0 CB A:CYS303 4.0 5.4 0.8 CD2 A:TRP111 4.0 4.0 1.0 CG A:TRP111 4.0 4.1 1.0 CG2 A:THR113 4.0 5.4 1.0 C27 A:LDT320 4.1 4.0 0.8 SG A:CYS303 4.1 5.9 0.8 C26 A:LDT320 4.2 4.2 0.8 CE1 A:PHE115 4.2 5.0 1.0 CD1 A:TYR309 4.4 5.1 0.8 CE1 A:TYR309 4.5 5.4 0.8 SG A:CYS80 4.6 3.9 1.0 CZ3 A:TRP111 4.7 4.7 1.0 C24 A:LDT320 4.7 4.2 0.8 CA A:LEU300 4.8 7.1 0.2 CE2 A:TRP111 4.9 4.4 1.0 CD1 A:TRP111 4.9 4.7 1.0

Reference: