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Bromine in PDB 2vr4: Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Enzymatic activity of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
All present enzymatic activity of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure:
3.2.1.25;
3.2.1.25;
Protein crystallography data
The structure of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure, PDB code: 2vr4
was solved by
L.E.Tailford,
W.A.Offen,
N.L.Smith,
C.Dumon,
C.Moreland,
J.Gratien,
M.P.Heck,
R.V.Stick,
Y.Bleriot,
A.Vasella,
H.J.Gilbert,
G.J.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 65.37 / 1.8 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 91.195, 114.738, 99.173, 90.00, 113.03, 90.00 |
| R / Rfree (%) | 17.7 / 22.2 |
Other elements in 2vr4:
The structure of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure also contains other interesting chemical elements:
| Chlorine | (Cl) | 11 atoms |
Bromine Binding Sites:
The binding sites of Bromine atom in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
(pdb code 2vr4). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 8 binding sites of Bromine where determined in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure, PDB code: 2vr4:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Bromine where determined in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure, PDB code: 2vr4:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Bromine binding site 1 out of 8 in 2vr4
Go back to
Bromine Binding Sites List in 2vr4
Bromine binding site 1 out
of 8 in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure within 5.0Å range:
|
Bromine binding site 2 out of 8 in 2vr4
Go back to
Bromine Binding Sites List in 2vr4
Bromine binding site 2 out
of 8 in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 2 of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure within 5.0Å range:
|
Bromine binding site 3 out of 8 in 2vr4
Go back to
Bromine Binding Sites List in 2vr4
Bromine binding site 3 out
of 8 in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 3 of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure within 5.0Å range:
|
Bromine binding site 4 out of 8 in 2vr4
Go back to
Bromine Binding Sites List in 2vr4
Bromine binding site 4 out
of 8 in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 4 of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure within 5.0Å range:
|
Bromine binding site 5 out of 8 in 2vr4
Go back to
Bromine Binding Sites List in 2vr4
Bromine binding site 5 out
of 8 in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 5 of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure within 5.0Å range:
|
Bromine binding site 6 out of 8 in 2vr4
Go back to
Bromine Binding Sites List in 2vr4
Bromine binding site 6 out
of 8 in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 6 of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure within 5.0Å range:
|
Bromine binding site 7 out of 8 in 2vr4
Go back to
Bromine Binding Sites List in 2vr4
Bromine binding site 7 out
of 8 in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 7 of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure within 5.0Å range:
|
Bromine binding site 8 out of 8 in 2vr4
Go back to
Bromine Binding Sites List in 2vr4
Bromine binding site 8 out
of 8 in the Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 8 of Transition-State Mimicry in Mannoside Hydrolysis: Characterisation of Twenty Six Inhibitors and Insight Into Binding From Linear Free Energy Relationships and 3-D Structure within 5.0Å range:
|
Reference:
L.E.Tailford,
W.A.Offen,
N.L.Smith,
C.Dumon,
C.Morland,
J.Gratien,
M.P.Heck,
R.V.Stick,
Y.Bleriot,
A.Vasella,
H.J.Gilbert,
G.J.Davies.
Structural and Biochemical Evidence For A Boat-Like Transition State in Beta-Mannosidases. Nat.Chem.Biol. V. 4 306 2008.
ISSN: ISSN 1552-4450
PubMed: 18408714
DOI: 10.1038/NCHEMBIO.81
Page generated: Wed Jul 10 18:45:32 2024
ISSN: ISSN 1552-4450
PubMed: 18408714
DOI: 10.1038/NCHEMBIO.81
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