Bromine in PDB 2vum: Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex

Enzymatic activity of Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex

All present enzymatic activity of Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex:
2.7.7.6;

Protein crystallography data

The structure of Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex, PDB code: 2vum was solved by F.Brueckner, P.Cramer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	50.00 / 3.40
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	220.619, 394.234, 283.966, 90.00, 90.00, 90.00
*R / R_free (%)*	25.5 / 28.8

Other elements in 2vum:

The structure of Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Zinc	(Zn)	8 atoms

Bromine Binding Sites:

The binding sites of Bromine atom in the Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex (pdb code 2vum). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex, PDB code: 2vum:

Bromine binding site 1 out of 1 in 2vum

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Bromine Binding Sites List in 2vum

Bromine binding site 1 out of 1 in the Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex

Mono view

Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Alpha-Amanitin Inhibited Complete Rna Polymerase II Elongation Complex within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
T:Br22 b:69.3 occ:1.00	BR	T:BRU22	0.0	69.3	1.0
	C5	T:BRU22	1.9	72.3	1.0
	C6	T:BRU22	2.8	74.2	1.0
	C4	T:BRU22	2.8	72.9	1.0
	O4	T:BRU22	3.1	73.5	1.0
	C6	T:DC21	3.1	81.3	1.0
	C5	T:DC21	3.3	82.0	1.0
	C2'	T:DC21	3.7	77.3	1.0
	N1	T:DC21	3.7	81.3	1.0
	OP2	T:BRU22	3.8	72.8	1.0
	C4	T:DC21	4.1	82.1	1.0
	C3'	T:DC21	4.1	76.3	1.0
	N3	T:BRU22	4.1	74.2	1.0
	N1	T:BRU22	4.1	76.0	1.0
	C1'	T:DC21	4.3	79.0	1.0
	C2	T:DC21	4.4	82.9	1.0
	O5'	T:BRU22	4.5	76.2	1.0
	N3	T:DC21	4.5	82.5	1.0
	P	T:BRU22	4.7	74.2	1.0
	C2	T:BRU22	4.7	75.2	1.0
	N4	T:DC21	4.8	83.5	1.0
	O3'	T:DC21	4.9	74.7	1.0
	O5'	T:DC21	5.0	79.3	1.0

Reference:

F.Brueckner, P.Cramer. Structural Basis of Transcription Inhibition By Alpha-Amanitin and Implications For Rna Polymerase II Translocation. Nat.Struct.Mol.Biol. V. 15 811 2008.
ISSN: ISSN 1545-9993
PubMed: 18552824
DOI: 10.1038/NSMB.1458

Page generated: Sat Dec 12 02:09:07 2020

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