Bromine in PDB 2wbb: Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Enzymatic activity of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
All present enzymatic activity of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor:
3.1.3.11;
Protein crystallography data
The structure of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor, PDB code: 2wbb
was solved by
A.Ruf,
C.Joseph,
J.Benz,
B.Fol,
T.Tetaz,
E.Kitas,
P.Mohr,
B.Kuhn,
H.P.Wessel,
P.Hebeisen,
W.Haap,
W.Huber,
R.Alvarez Sanchez,
A.Paehler,
A.Bernadeau,
M.Gubler,
B.Schott,
E.Tozzo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
29.70 /
2.22
|
Space group
|
P 1 21 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
64.730,
278.563,
82.702,
90.00,
97.87,
90.00
|
R / Rfree (%)
|
19.9 /
24.8
|
Bromine Binding Sites:
The binding sites of Bromine atom in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
(pdb code 2wbb). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 8 binding sites of Bromine where determined in the
Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor, PDB code: 2wbb:
Jump to Bromine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Bromine binding site 1 out
of 8 in 2wbb
Go back to
Bromine Binding Sites List in 2wbb
Bromine binding site 1 out
of 8 in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Mono view
Stereo pair view
|
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Br1336
b:58.3
occ:1.00
|
BR2
|
A:RO31336
|
0.0
|
58.3
|
1.0
|
C14
|
A:RO31336
|
1.9
|
55.1
|
1.0
|
C15
|
A:RO31336
|
2.9
|
54.1
|
1.0
|
S16
|
A:RO31336
|
3.1
|
51.5
|
1.0
|
CA
|
C:GLY28
|
3.5
|
32.3
|
1.0
|
S16
|
C:RO31336
|
3.5
|
51.3
|
1.0
|
CG
|
A:MET18
|
3.5
|
36.8
|
1.0
|
O
|
C:GLY28
|
3.5
|
31.2
|
1.0
|
C
|
C:GLY28
|
3.9
|
31.7
|
1.0
|
CD
|
A:ARG22
|
3.9
|
46.0
|
1.0
|
N17
|
A:RO31336
|
4.0
|
53.1
|
1.0
|
CB
|
A:MET18
|
4.1
|
35.9
|
1.0
|
SD
|
A:MET18
|
4.1
|
39.4
|
1.0
|
C4
|
A:RO31336
|
4.2
|
50.2
|
1.0
|
CG
|
A:ARG22
|
4.3
|
43.3
|
1.0
|
C14
|
C:RO31336
|
4.3
|
54.5
|
1.0
|
CB
|
C:THR31
|
4.4
|
29.1
|
1.0
|
CG2
|
C:THR31
|
4.4
|
28.2
|
1.0
|
BR2
|
C:RO31336
|
4.5
|
58.2
|
1.0
|
CA
|
A:MET18
|
4.7
|
36.2
|
1.0
|
N
|
C:GLY28
|
4.7
|
33.7
|
1.0
|
OE1
|
C:GLN32
|
4.7
|
38.2
|
1.0
|
CE
|
A:MET18
|
4.8
|
38.2
|
1.0
|
O
|
A:MET18
|
4.8
|
35.7
|
1.0
|
C4
|
C:RO31336
|
4.8
|
50.6
|
1.0
|
O
|
C:THR27
|
4.9
|
33.9
|
1.0
|
O1
|
C:RO31336
|
4.9
|
40.6
|
1.0
|
|
Bromine binding site 2 out
of 8 in 2wbb
Go back to
Bromine Binding Sites List in 2wbb
Bromine binding site 2 out
of 8 in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Mono view
Stereo pair view
|
A full contact list of Bromine with other atoms in the Br binding
site number 2 of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Br1336
b:53.8
occ:1.00
|
BR2
|
B:RO31336
|
0.0
|
53.8
|
1.0
|
C14
|
B:RO31336
|
1.9
|
50.4
|
1.0
|
C15
|
B:RO31336
|
2.9
|
50.2
|
1.0
|
S16
|
B:RO31336
|
3.1
|
48.0
|
1.0
|
CG
|
B:MET18
|
3.6
|
36.5
|
1.0
|
O
|
D:GLY28
|
3.7
|
29.1
|
1.0
|
SD
|
B:MET18
|
3.7
|
37.6
|
1.0
|
CA
|
D:GLY28
|
3.8
|
29.4
|
1.0
|
S16
|
D:RO31336
|
3.8
|
46.9
|
1.0
|
CB
|
B:MET18
|
4.0
|
35.4
|
1.0
|
CD
|
B:ARG22
|
4.1
|
35.9
|
0.5
|
N17
|
B:RO31336
|
4.1
|
49.5
|
1.0
|
C14
|
D:RO31336
|
4.1
|
52.2
|
1.0
|
CG2
|
D:THR31
|
4.1
|
26.8
|
1.0
|
CG
|
D:GLN32
|
4.2
|
28.2
|
1.0
|
C
|
D:GLY28
|
4.2
|
28.9
|
1.0
|
C4
|
B:RO31336
|
4.2
|
46.7
|
1.0
|
CB
|
D:THR31
|
4.3
|
27.1
|
1.0
|
BR2
|
D:RO31336
|
4.3
|
56.0
|
1.0
|
CG
|
B:ARG22
|
4.5
|
35.8
|
0.5
|
CE
|
B:MET18
|
4.6
|
36.2
|
1.0
|
CA
|
B:MET18
|
4.6
|
35.6
|
1.0
|
C4
|
D:RO31336
|
4.7
|
46.6
|
1.0
|
O1
|
D:RO31336
|
4.8
|
39.0
|
1.0
|
CD
|
D:GLN32
|
4.8
|
29.2
|
1.0
|
N
|
D:GLN32
|
4.9
|
26.1
|
1.0
|
C15
|
D:RO31336
|
4.9
|
51.1
|
1.0
|
O
|
B:MET18
|
5.0
|
36.1
|
1.0
|
|
Bromine binding site 3 out
of 8 in 2wbb
Go back to
Bromine Binding Sites List in 2wbb
Bromine binding site 3 out
of 8 in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Mono view
Stereo pair view
|
A full contact list of Bromine with other atoms in the Br binding
site number 3 of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Br1336
b:58.2
occ:1.00
|
BR2
|
C:RO31336
|
0.0
|
58.2
|
1.0
|
C14
|
C:RO31336
|
1.9
|
54.5
|
1.0
|
C15
|
C:RO31336
|
2.9
|
54.4
|
1.0
|
S16
|
C:RO31336
|
3.1
|
51.3
|
1.0
|
CG
|
C:MET18
|
3.7
|
36.3
|
1.0
|
O
|
A:GLY28
|
3.7
|
30.2
|
1.0
|
CA
|
A:GLY28
|
3.8
|
31.2
|
1.0
|
SD
|
C:MET18
|
3.9
|
37.8
|
1.0
|
N17
|
C:RO31336
|
4.0
|
54.2
|
1.0
|
CB
|
C:MET18
|
4.1
|
35.9
|
1.0
|
C14
|
A:RO31336
|
4.1
|
55.1
|
1.0
|
S16
|
A:RO31336
|
4.1
|
51.5
|
1.0
|
CB
|
A:THR31
|
4.2
|
27.5
|
1.0
|
C
|
A:GLY28
|
4.2
|
30.7
|
1.0
|
C4
|
C:RO31336
|
4.2
|
50.6
|
1.0
|
CG2
|
A:THR31
|
4.3
|
27.8
|
1.0
|
BR2
|
A:RO31336
|
4.5
|
58.3
|
1.0
|
CE
|
C:MET18
|
4.5
|
35.8
|
1.0
|
OE1
|
A:GLN32
|
4.6
|
32.9
|
1.0
|
O1
|
A:RO31336
|
4.6
|
40.8
|
1.0
|
C15
|
A:RO31336
|
4.6
|
54.1
|
1.0
|
CA
|
C:MET18
|
4.7
|
36.0
|
1.0
|
C4
|
A:RO31336
|
4.7
|
50.2
|
1.0
|
O
|
C:MET18
|
4.8
|
35.5
|
1.0
|
N
|
A:GLN32
|
4.9
|
27.8
|
1.0
|
N17
|
A:RO31336
|
4.9
|
53.1
|
1.0
|
OG1
|
A:THR31
|
4.9
|
26.5
|
1.0
|
|
Bromine binding site 4 out
of 8 in 2wbb
Go back to
Bromine Binding Sites List in 2wbb
Bromine binding site 4 out
of 8 in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Mono view
Stereo pair view
|
A full contact list of Bromine with other atoms in the Br binding
site number 4 of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Br1336
b:56.0
occ:1.00
|
BR2
|
D:RO31336
|
0.0
|
56.0
|
1.0
|
C14
|
D:RO31336
|
1.9
|
52.2
|
1.0
|
C15
|
D:RO31336
|
2.9
|
51.1
|
1.0
|
S16
|
D:RO31336
|
3.1
|
46.9
|
1.0
|
CA
|
B:GLY28
|
3.6
|
28.9
|
1.0
|
CG
|
D:MET18
|
3.6
|
35.9
|
1.0
|
O
|
B:GLY28
|
3.7
|
28.4
|
1.0
|
S16
|
B:RO31336
|
3.7
|
48.0
|
1.0
|
C14
|
B:RO31336
|
3.9
|
50.4
|
1.0
|
SD
|
D:MET18
|
3.9
|
37.4
|
1.0
|
CB
|
D:MET18
|
4.0
|
34.5
|
1.0
|
N17
|
D:RO31336
|
4.1
|
50.5
|
1.0
|
CG2
|
B:THR31
|
4.1
|
24.1
|
1.0
|
C
|
B:GLY28
|
4.1
|
28.7
|
1.0
|
CD
|
D:ARG22
|
4.1
|
39.9
|
1.0
|
CB
|
B:THR31
|
4.2
|
24.4
|
1.0
|
C4
|
D:RO31336
|
4.2
|
46.6
|
1.0
|
BR2
|
B:RO31336
|
4.3
|
53.8
|
1.0
|
CG
|
B:GLN32
|
4.4
|
28.7
|
1.0
|
C4
|
B:RO31336
|
4.4
|
46.7
|
1.0
|
CE
|
D:MET18
|
4.5
|
36.5
|
1.0
|
C15
|
B:RO31336
|
4.5
|
50.2
|
1.0
|
O1
|
B:RO31336
|
4.7
|
41.7
|
1.0
|
CG
|
D:ARG22
|
4.7
|
38.7
|
1.0
|
CA
|
D:MET18
|
4.7
|
34.5
|
1.0
|
N17
|
B:RO31336
|
4.8
|
49.5
|
1.0
|
N
|
B:GLN32
|
4.9
|
25.0
|
1.0
|
N
|
B:GLY28
|
4.9
|
30.4
|
1.0
|
O
|
D:MET18
|
4.9
|
34.9
|
1.0
|
|
Bromine binding site 5 out
of 8 in 2wbb
Go back to
Bromine Binding Sites List in 2wbb
Bromine binding site 5 out
of 8 in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Mono view
Stereo pair view
|
A full contact list of Bromine with other atoms in the Br binding
site number 5 of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Br1336
b:57.9
occ:1.00
|
BR2
|
E:RO31336
|
0.0
|
57.9
|
1.0
|
C14
|
E:RO31336
|
1.9
|
52.6
|
1.0
|
C15
|
E:RO31336
|
2.9
|
52.3
|
1.0
|
S16
|
E:RO31336
|
3.1
|
49.2
|
1.0
|
CA
|
G:GLY28
|
3.5
|
31.8
|
1.0
|
O
|
G:GLY28
|
3.5
|
31.2
|
1.0
|
S16
|
G:RO31336
|
3.7
|
46.5
|
1.0
|
C
|
G:GLY28
|
3.9
|
31.8
|
1.0
|
CB
|
E:MET18
|
4.0
|
32.9
|
1.0
|
CG
|
E:MET18
|
4.0
|
33.0
|
1.0
|
O
|
G:HOH2006
|
4.0
|
48.5
|
1.0
|
SD
|
E:MET18
|
4.0
|
34.9
|
1.0
|
C14
|
G:RO31336
|
4.0
|
51.4
|
1.0
|
N17
|
E:RO31336
|
4.1
|
51.8
|
1.0
|
BR2
|
G:RO31336
|
4.2
|
55.7
|
1.0
|
C4
|
E:RO31336
|
4.2
|
47.3
|
1.0
|
CB
|
G:THR31
|
4.4
|
27.6
|
1.0
|
CG2
|
G:THR31
|
4.5
|
27.3
|
1.0
|
CA
|
E:MET18
|
4.6
|
32.7
|
1.0
|
C4
|
G:RO31336
|
4.7
|
47.5
|
1.0
|
OE1
|
G:GLN32
|
4.7
|
36.2
|
1.0
|
O
|
E:MET18
|
4.7
|
32.7
|
1.0
|
O1
|
G:RO31336
|
4.8
|
43.2
|
1.0
|
CE
|
E:MET18
|
4.8
|
34.4
|
1.0
|
CG
|
G:GLN32
|
4.8
|
31.1
|
1.0
|
N
|
G:GLY28
|
4.8
|
32.4
|
1.0
|
O
|
G:THR27
|
4.8
|
32.8
|
1.0
|
C15
|
G:RO31336
|
4.9
|
50.9
|
1.0
|
N
|
G:GLN32
|
5.0
|
27.8
|
1.0
|
|
Bromine binding site 6 out
of 8 in 2wbb
Go back to
Bromine Binding Sites List in 2wbb
Bromine binding site 6 out
of 8 in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Mono view
Stereo pair view
|
A full contact list of Bromine with other atoms in the Br binding
site number 6 of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Br1336
b:55.4
occ:1.00
|
BR2
|
F:RO31336
|
0.0
|
55.4
|
1.0
|
C14
|
F:RO31336
|
1.9
|
52.9
|
1.0
|
C15
|
F:RO31336
|
2.9
|
52.4
|
1.0
|
S16
|
F:RO31336
|
3.1
|
50.2
|
1.0
|
CA
|
H:GLY28
|
3.6
|
30.6
|
1.0
|
SD
|
F:MET18
|
3.6
|
38.9
|
1.0
|
CG
|
F:MET18
|
3.6
|
36.3
|
1.0
|
S16
|
H:RO31336
|
3.6
|
50.7
|
1.0
|
O
|
H:GLY28
|
3.7
|
30.2
|
1.0
|
C14
|
H:RO31336
|
4.0
|
53.6
|
1.0
|
C
|
H:GLY28
|
4.1
|
30.2
|
1.0
|
N17
|
F:RO31336
|
4.1
|
51.4
|
1.0
|
CB
|
F:MET18
|
4.1
|
35.7
|
1.0
|
CG2
|
H:THR31
|
4.1
|
27.6
|
1.0
|
CB
|
H:THR31
|
4.2
|
28.2
|
1.0
|
C4
|
F:RO31336
|
4.2
|
48.7
|
1.0
|
BR2
|
H:RO31336
|
4.3
|
56.8
|
1.0
|
CD
|
F:ARG22
|
4.4
|
37.9
|
0.5
|
CG
|
F:ARG22
|
4.5
|
37.8
|
0.5
|
C4
|
H:RO31336
|
4.6
|
49.3
|
1.0
|
O1
|
H:RO31336
|
4.6
|
41.9
|
1.0
|
CA
|
F:MET18
|
4.7
|
35.8
|
1.0
|
O
|
F:MET18
|
4.8
|
35.6
|
1.0
|
N
|
H:GLY28
|
4.8
|
32.2
|
1.0
|
C15
|
H:RO31336
|
4.9
|
53.1
|
1.0
|
O
|
H:THR27
|
4.9
|
33.3
|
1.0
|
OG1
|
H:THR31
|
4.9
|
28.8
|
1.0
|
N
|
H:GLN32
|
5.0
|
27.7
|
1.0
|
CG
|
H:GLN32
|
5.0
|
29.4
|
1.0
|
|
Bromine binding site 7 out
of 8 in 2wbb
Go back to
Bromine Binding Sites List in 2wbb
Bromine binding site 7 out
of 8 in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Mono view
Stereo pair view
|
A full contact list of Bromine with other atoms in the Br binding
site number 7 of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:Br1336
b:55.7
occ:1.00
|
BR2
|
G:RO31336
|
0.0
|
55.7
|
1.0
|
C14
|
G:RO31336
|
1.9
|
51.4
|
1.0
|
C15
|
G:RO31336
|
2.9
|
50.9
|
1.0
|
S16
|
G:RO31336
|
3.1
|
46.5
|
1.0
|
S16
|
E:RO31336
|
3.5
|
49.2
|
1.0
|
CA
|
E:GLY28
|
3.5
|
29.4
|
1.0
|
O
|
E:GLY28
|
3.6
|
28.3
|
1.0
|
CG
|
G:MET18
|
3.8
|
32.8
|
1.0
|
C14
|
E:RO31336
|
4.0
|
52.6
|
1.0
|
C
|
E:GLY28
|
4.0
|
28.7
|
1.0
|
N17
|
G:RO31336
|
4.0
|
51.0
|
1.0
|
SD
|
G:MET18
|
4.0
|
34.2
|
1.0
|
CG2
|
E:THR31
|
4.1
|
24.4
|
1.0
|
CB
|
E:THR31
|
4.1
|
25.0
|
1.0
|
BR2
|
E:RO31336
|
4.2
|
57.9
|
1.0
|
C4
|
G:RO31336
|
4.2
|
47.5
|
1.0
|
CB
|
G:MET18
|
4.2
|
31.8
|
1.0
|
O1
|
E:RO31336
|
4.6
|
38.7
|
1.0
|
CG
|
E:GLN32
|
4.6
|
28.2
|
1.0
|
C4
|
E:RO31336
|
4.6
|
47.3
|
1.0
|
CE
|
G:MET18
|
4.6
|
33.2
|
1.0
|
OG1
|
E:THR31
|
4.8
|
24.4
|
1.0
|
CA
|
G:MET18
|
4.8
|
32.2
|
1.0
|
N
|
E:GLY28
|
4.8
|
30.5
|
1.0
|
C15
|
E:RO31336
|
4.9
|
52.3
|
1.0
|
NE2
|
E:GLN32
|
5.0
|
32.4
|
1.0
|
N
|
E:GLN32
|
5.0
|
24.9
|
1.0
|
|
Bromine binding site 8 out
of 8 in 2wbb
Go back to
Bromine Binding Sites List in 2wbb
Bromine binding site 8 out
of 8 in the Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor
Mono view
Stereo pair view
|
A full contact list of Bromine with other atoms in the Br binding
site number 8 of Fructose-1,6-Bisphosphatase(D-Fructose-1,6-Bisphosphate-1- Phosphohydrolase) (E.C.3.1.3.11) Complexed with An Amp Site Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:Br1336
b:56.8
occ:1.00
|
BR2
|
H:RO31336
|
0.0
|
56.8
|
1.0
|
C14
|
H:RO31336
|
1.9
|
53.6
|
1.0
|
C15
|
H:RO31336
|
2.9
|
53.1
|
1.0
|
S16
|
H:RO31336
|
3.1
|
50.7
|
1.0
|
O
|
F:GLY28
|
3.5
|
30.8
|
1.0
|
CA
|
F:GLY28
|
3.5
|
31.0
|
1.0
|
CG
|
H:MET18
|
3.6
|
36.6
|
1.0
|
S16
|
F:RO31336
|
3.7
|
50.2
|
1.0
|
SD
|
H:MET18
|
3.8
|
37.9
|
1.0
|
C
|
F:GLY28
|
3.9
|
30.6
|
1.0
|
CB
|
H:MET18
|
3.9
|
35.9
|
1.0
|
C14
|
F:RO31336
|
4.0
|
52.9
|
1.0
|
N17
|
H:RO31336
|
4.0
|
52.7
|
1.0
|
CG2
|
F:THR31
|
4.2
|
25.3
|
1.0
|
C4
|
H:RO31336
|
4.2
|
49.3
|
1.0
|
BR2
|
F:RO31336
|
4.3
|
55.4
|
1.0
|
CB
|
F:THR31
|
4.3
|
25.7
|
1.0
|
CG
|
H:ARG22
|
4.4
|
39.8
|
1.0
|
CD
|
H:ARG22
|
4.4
|
39.5
|
1.0
|
CG
|
F:GLN32
|
4.5
|
27.7
|
1.0
|
CE
|
H:MET18
|
4.5
|
36.6
|
1.0
|
C4
|
F:RO31336
|
4.6
|
48.7
|
1.0
|
CA
|
H:MET18
|
4.7
|
35.9
|
1.0
|
O1
|
F:RO31336
|
4.7
|
39.8
|
1.0
|
O
|
H:MET18
|
4.7
|
35.5
|
1.0
|
C15
|
F:RO31336
|
4.8
|
52.4
|
1.0
|
N
|
F:GLY28
|
4.8
|
32.2
|
1.0
|
N
|
F:GLN32
|
4.9
|
25.5
|
1.0
|
O
|
F:THR27
|
5.0
|
32.7
|
1.0
|
CD
|
F:GLN32
|
5.0
|
33.0
|
1.0
|
|
Reference:
E.Kitas,
P.Mohr,
B.Kuhn,
H.P.Wessel,
P.Hebeisen,
W.Haap,
A.Ruf,
J.Benz,
C.Joseph,
W.Huber,
R.Alvarez Sanchez,
A.Paehler,
A.Bernadeau,
M.Gubler,
B.Schott,
E.Tozzo.
Sulfonylureido Thiazoles As Fructose-1,6- Bisphosphatase Inhibitors For the Treatment of Type-2 Diabetes. Bioorg.Med.Chem.Lett. V. 20 594 2010.
ISSN: ISSN 0960-894X
PubMed: 19969452
DOI: 10.1016/J.BMCL.2009.11.093
Page generated: Wed Jul 10 18:48:37 2024
|