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Bromine in PDB 2who: Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor
Enzymatic activity of Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor:
2.7.7.48;
2.7.7.48;
Protein crystallography data
The structure of Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor, PDB code: 2who
was solved by
S.Di Marco,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 95.35 / 2.00 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 67.210, 96.999, 193.762, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.1 / 26.6 |
Other elements in 2who:
The structure of Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor also contains other interesting chemical elements:
| Manganese | (Mn) | 4 atoms |
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor
(pdb code 2who). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor, PDB code: 2who:
Jump to Bromine binding site number: 1; 2;
In total 2 binding sites of Bromine where determined in the Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor, PDB code: 2who:
Jump to Bromine binding site number: 1; 2;
Bromine binding site 1 out of 2 in 2who
Go back to
Bromine Binding Sites List in 2who
Bromine binding site 1 out
of 2 in the Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor within 5.0Å range:
|
Bromine binding site 2 out of 2 in 2who
Go back to
Bromine Binding Sites List in 2who
Bromine binding site 2 out
of 2 in the Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 2 of Crystal Structure of Hepatitis C Virus NS5B Polymerase From 1B Genotype in Complex with A Non-Nucleoside Inhibitor within 5.0Å range:
|
Reference:
J.M.Ontoria,
E.H.Rydberg,
S.Di Marco,
L.Tomei,
B.Attenni,
S.Malancona,
J.I.Martin Hernando,
N.Gennari,
U.Koch,
F.Narjes,
M.Rowley,
V.Summa,
S.S.Carroll,
D.B.Olsen,
R.De Francesco,
S.Altamura,
G.Migliaccio,
A.Carfi.
Identification and Biological Evaluation of A Series of 1H-Benzo[De]Isoquinoline-1,3(2H)-Diones As Hepatitis C Virus NS5B Polymerase Inhibitors. J. Med. Chem. V. 52 5217 2009.
ISSN: ISSN 1520-4804
PubMed: 19877603
DOI: 10.1021/JM900517T
Page generated: Wed Jul 10 18:51:43 2024
ISSN: ISSN 1520-4804
PubMed: 19877603
DOI: 10.1021/JM900517T
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