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Atomistry » Bromine » PDB 2vot-2xo8 » 2wp5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 2vot-2xo8 » 2wp5 » |
Bromine in PDB 2wp5: Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414)Enzymatic activity of Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414)
All present enzymatic activity of Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414):
1.8.1.12; Protein crystallography data
The structure of Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414), PDB code: 2wp5
was solved by
M.S.Alphey,
S.Patterson,
A.H.Fairlamb,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2wp5:
The structure of Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414) also contains other interesting chemical elements:
Bromine Binding Sites:
The binding sites of Bromine atom in the Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414)
(pdb code 2wp5). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 4 binding sites of Bromine where determined in the Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414), PDB code: 2wp5: Jump to Bromine binding site number: 1; 2; 3; 4; Bromine binding site 1 out of 4 in 2wp5Go back to Bromine Binding Sites List in 2wp5
Bromine binding site 1 out
of 4 in the Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414)
Mono view Stereo pair view
Bromine binding site 2 out of 4 in 2wp5Go back to Bromine Binding Sites List in 2wp5
Bromine binding site 2 out
of 4 in the Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414)
Mono view Stereo pair view
Bromine binding site 3 out of 4 in 2wp5Go back to Bromine Binding Sites List in 2wp5
Bromine binding site 3 out
of 4 in the Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414)
Mono view Stereo pair view
Bromine binding site 4 out of 4 in 2wp5Go back to Bromine Binding Sites List in 2wp5
Bromine binding site 4 out
of 4 in the Trypanosoma Brucei Trypanothione Reductase in Complex with 3,4-Dihydroquinazoline Inhibitor (DDD00065414)
Mono view Stereo pair view
Reference:
S.Patterson,
M.S.Alphey,
D.C.Jones,
E.J.Shanks,
I.P.Street,
J.A.Frearson,
P.G.Wyatt,
I.H.Gilbert,
A.H.Fairlamb.
Dihydroquinazolines As A Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode By Protein Crystallography. J.Med.Chem. V. 54 6514 2011.
Page generated: Wed Jul 10 18:53:36 2024
ISSN: ISSN 0022-2623 PubMed: 21851087 DOI: 10.1021/JM200312V |
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