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Atomistry » Bromine » PDB 2vot-2xo8 » 2x6e | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 2vot-2xo8 » 2x6e » |
Bromine in PDB 2x6e: Aurora-A Bound to An InhibitorEnzymatic activity of Aurora-A Bound to An Inhibitor
All present enzymatic activity of Aurora-A Bound to An Inhibitor:
2.7.11.1; Protein crystallography data
The structure of Aurora-A Bound to An Inhibitor, PDB code: 2x6e
was solved by
M.Kosmopoulou,
R.Bayliss,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the Aurora-A Bound to An Inhibitor
(pdb code 2x6e). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Aurora-A Bound to An Inhibitor, PDB code: 2x6e: Bromine binding site 1 out of 1 in 2x6eGo back to Bromine Binding Sites List in 2x6e
Bromine binding site 1 out
of 1 in the Aurora-A Bound to An Inhibitor
Mono view Stereo pair view
Reference:
V.Bavetsias,
J.M.Large,
C.Sun,
N.Bouloc,
M.Kosmopoulou,
M.Matteucci,
N.E.Wilsher,
V.Martins,
J.Reynisson,
B.Atrash,
A.Faisal,
F.Urban,
M.Valenti,
A.De Haven Brandon,
G.Box,
F.I.Raynaud,
P.Workman,
S.A.Eccles,
R.Bayliss,
J.Blagg,
S.Linardopoulos,
E.Mcdonald.
Imidazo[4,5-B]Pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies Toward the Identification of An Orally Bioavailable Preclinical Development Candidate. J. Med. Chem. V. 53 5213 2010.
Page generated: Sat Dec 12 02:09:42 2020
ISSN: ISSN 1520-4804 PubMed: 20565112 DOI: 10.1021/JM100262J |
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