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PDB 2xpn-3bnq »
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Bromine in PDB 2y5l: Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Enzymatic activity of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
All present enzymatic activity of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase:
3.1.3.11;
3.1.3.11;
Protein crystallography data
The structure of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase, PDB code: 2y5l
was solved by
A.Ruf,
P.Hebeisen,
W.Haap,
B.Kuhn,
P.Mohr,
H.P.Wessel,
U.Zutter,
S.Kirchner,
J.Benz,
C.Joseph,
R.Alvarez-Sanchez,
M.Gubler,
B.Schott,
A.Benardeau,
E.Tozzo,
E.Kitas,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 142.86 / 2.20 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 66.791, 285.084, 83.687, 90.00, 97.30, 90.00 |
| R / Rfree (%) | 20.497 / 25.375 |
Other elements in 2y5l:
The structure of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase also contains other interesting chemical elements:
| Chlorine | (Cl) | 8 atoms |
Bromine Binding Sites:
The binding sites of Bromine atom in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
(pdb code 2y5l). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 8 binding sites of Bromine where determined in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase, PDB code: 2y5l:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Bromine where determined in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase, PDB code: 2y5l:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Bromine binding site 1 out of 8 in 2y5l
Go back to
Bromine Binding Sites List in 2y5l
Bromine binding site 1 out
of 8 in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase within 5.0Å range:
|
Bromine binding site 2 out of 8 in 2y5l
Go back to
Bromine Binding Sites List in 2y5l
Bromine binding site 2 out
of 8 in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 2 of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase within 5.0Å range:
|
Bromine binding site 3 out of 8 in 2y5l
Go back to
Bromine Binding Sites List in 2y5l
Bromine binding site 3 out
of 8 in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 3 of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase within 5.0Å range:
|
Bromine binding site 4 out of 8 in 2y5l
Go back to
Bromine Binding Sites List in 2y5l
Bromine binding site 4 out
of 8 in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 4 of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase within 5.0Å range:
|
Bromine binding site 5 out of 8 in 2y5l
Go back to
Bromine Binding Sites List in 2y5l
Bromine binding site 5 out
of 8 in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 5 of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase within 5.0Å range:
|
Bromine binding site 6 out of 8 in 2y5l
Go back to
Bromine Binding Sites List in 2y5l
Bromine binding site 6 out
of 8 in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 6 of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase within 5.0Å range:
|
Bromine binding site 7 out of 8 in 2y5l
Go back to
Bromine Binding Sites List in 2y5l
Bromine binding site 7 out
of 8 in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 7 of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase within 5.0Å range:
|
Bromine binding site 8 out of 8 in 2y5l
Go back to
Bromine Binding Sites List in 2y5l
Bromine binding site 8 out
of 8 in the Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 8 of Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose 1,6-Bisphosphatase within 5.0Å range:
|
Reference:
P.Hebeisen,
W.Haap,
B.Kuhn,
P.Mohr,
H.P.Wessel,
U.Zutter,
S.Kirchner,
A.Ruf,
J.Benz,
C.Joseph,
R.Alvarez-Sanchez,
M.Gubler,
B.Schott,
A.Benardeau,
E.Tozzo,
E.Kitas.
Orally Active Aminopyridines As Inhibitors of Tetrameric Fructose-1,6-Bisphosphatase. Bioorg.Med.Chem.Lett. V. 21 3237 2011.
ISSN: ISSN 0960-894X
PubMed: 21550236
DOI: 10.1016/J.BMCL.2011.04.044
Page generated: Sat Dec 12 02:09:58 2020
ISSN: ISSN 0960-894X
PubMed: 21550236
DOI: 10.1016/J.BMCL.2011.04.044
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