Atomistry » Bromine » PDB 2xpn-3bnq » 3biy
Atomistry »
  Bromine »
    PDB 2xpn-3bnq »
      3biy »

Bromine in PDB 3biy: Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa

Enzymatic activity of Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa

All present enzymatic activity of Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa, PDB code: 3biy was solved by X.Liu, L.Wang, K.Zhao, P.R.Thompson, Y.Hwang, R.Marmorstein, P.A.Cole, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 26.65 / 1.70
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 61.513, 61.513, 101.153, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 21.3

Bromine Binding Sites:

The binding sites of Bromine atom in the Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa (pdb code 3biy). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 5 binding sites of Bromine where determined in the Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa, PDB code: 3biy:
Jump to Bromine binding site number: 1; 2; 3; 4; 5;

Bromine binding site 1 out of 5 in 3biy

Go back to Bromine Binding Sites List in 3biy
Bromine binding site 1 out of 5 in the Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1521

b:37.4
occ:0.81
 O A:HOH1693 2.9 23.1 1.0
O A:HOH1675 3.1 17.9 1.0
NZ A:LYS1426 3.6 20.0 1.0
CG1 A:ILE1479 3.8 17.3 1.0
O A:ARG1478 3.8 18.4 1.0
CE A:LYS1426 3.9 20.6 1.0
CD A:LYS1426 3.9 17.6 1.0
CA A:ILE1479 3.9 17.1 1.0
O A:HOH1842 4.2 30.5 1.0
CB A:ILE1479 4.3 17.2 1.0
CG A:GLU1423 4.4 19.3 1.0
C A:ARG1478 4.5 16.2 1.0
N A:ILE1479 4.6 16.1 1.0
CG2 A:ILE1479 4.6 18.1 1.0
O A:HOH1843 4.8 29.4 1.0
O A:HOH1665 4.8 17.6 1.0
O A:ILE1479 4.9 20.1 1.0
CG A:LYS1426 4.9 18.2 1.0
CD1 A:ILE1479 4.9 20.3 1.0
C A:ILE1479 5.0 18.3 1.0

Bromine binding site 2 out of 5 in 3biy

Go back to Bromine Binding Sites List in 3biy
Bromine binding site 2 out of 5 in the Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1522

b:37.6
occ:0.85
 O A:HOH1835 3.3 26.7 1.0
O A:HOH1706 3.4 27.7 1.0
NE2 A:GLN1661 3.6 34.9 1.0
CA A:LEU1623 3.8 21.7 1.0
N A:LEU1623 3.9 21.7 1.0
CB A:ALA1629 4.1 22.1 1.0
C A:ASP1622 4.1 23.0 1.0
CD1 A:LEU1623 4.1 21.2 1.0
CB A:LEU1623 4.3 21.3 1.0
O A:ASP1622 4.3 22.9 1.0
CB A:ASP1622 4.5 24.7 1.0
CD A:GLN1661 4.7 34.5 1.0
CG A:LEU1623 4.9 22.4 1.0
OE1 A:GLN1661 4.9 34.4 1.0
CA A:ASP1622 4.9 23.8 1.0
O A:HOH1763 5.0 28.9 1.0

Bromine binding site 3 out of 5 in 3biy

Go back to Bromine Binding Sites List in 3biy
Bromine binding site 3 out of 5 in the Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1523

b:43.6
occ:0.86
 O A:HOH1676 3.4 24.7 1.0

Bromine binding site 4 out of 5 in 3biy

Go back to Bromine Binding Sites List in 3biy
Bromine binding site 4 out of 5 in the Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1524

b:46.4
occ:0.76
 O A:HOH1829 3.0 26.3 1.0
O A:HOH1713 3.2 22.2 1.0
CA A:CYS1408 3.8 21.1 1.0
N A:CYS1408 4.0 20.1 1.0
CB A:LYS1407 4.1 20.7 1.0
C A:LYS1407 4.1 19.1 1.0
CB A:CYS1408 4.2 21.7 1.0
O A:LYS1407 4.3 19.7 1.0
O A:HOH1820 4.6 40.6 1.0
CE A:LYS1407 4.6 28.8 1.0
O A:HOH1790 4.7 35.9 1.0
CA A:LYS1407 4.8 19.9 1.0
O46 A:01K700 4.8 33.5 1.0
O A:HOH1679 4.9 22.6 1.0

Bromine binding site 5 out of 5 in 3biy

Go back to Bromine Binding Sites List in 3biy
Bromine binding site 5 out of 5 in the Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of Crystal Structure of P300 Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1525

b:45.8
occ:0.74
 O A:HOH1850 2.6 28.7 1.0
O A:HOH1679 3.1 22.6 1.0
N A:LYS1407 3.2 19.4 1.0
CA A:PRO1406 3.6 17.9 1.0
CB A:PRO1406 3.8 18.3 1.0
C A:PRO1406 4.0 18.4 1.0
CB A:LYS1407 4.0 20.7 1.0
CG A:LYS1407 4.2 24.2 1.0
CA A:LYS1407 4.2 19.9 1.0
CD A:LYS1407 4.5 25.9 1.0
O A:HOH1733 4.7 34.3 1.0
O A:HOH1829 5.0 26.3 1.0
N A:PRO1406 5.0 18.1 1.0

Reference:

X.Liu, L.Wang, K.Zhao, P.R.Thompson, Y.Hwang, R.Marmorstein, P.A.Cole. The Structural Basis of Protein Acetylation By the P300/Cbp Transcriptional Coactivator Nature V. 451 846 2008.
ISSN: ISSN 0028-0836
PubMed: 18273021
DOI: 10.1038/NATURE06546
Page generated: Mon Jul 7 05:03:13 2025

Last articles

Br in 5LQO
Br in 5LMK
Br in 5LIX
Br in 5LIW
Br in 5LFT
Br in 5LIK
Br in 5LIU
Br in 5LFX
Br in 5L7F
Br in 5LFW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy