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Atomistry » Bromine » PDB 3r3x-3tv4 » 3sie » |
Bromine in PDB 3sie: Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel InhibitorsEnzymatic activity of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
All present enzymatic activity of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors:
3.1.4.35; Protein crystallography data
The structure of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors, PDB code: 3sie
was solved by
T.T.Chen,
T.Chen,
Y.C.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
(pdb code 3sie). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors, PDB code: 3sie: Jump to Bromine binding site number: 1; 2; Bromine binding site 1 out of 2 in 3sieGo back to Bromine Binding Sites List in 3sie
Bromine binding site 1 out
of 2 in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
Mono view Stereo pair view
Bromine binding site 2 out of 2 in 3sieGo back to Bromine Binding Sites List in 3sie
Bromine binding site 2 out
of 2 in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
Mono view Stereo pair view
Reference:
Z.Xu,
Z.Liu,
T.Chen,
T.T.Chen,
Z.Wang,
G.Tian,
J.Shi,
X.Wang,
Y.Lu,
X.Yan,
G.Wang,
H.Jiang,
K.Chen,
S.Wang,
Y.Xu,
J.Shen,
W.Zhu.
Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J.Med.Chem. V. 54 5607 2011.
Page generated: Sat Dec 12 02:15:32 2020
ISSN: ISSN 0022-2623 PubMed: 21714539 DOI: 10.1021/JM200644R |
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