|
Atomistry » Bromine » PDB 4d4j-4g6v » 4er7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 4d4j-4g6v » 4er7 » |
Bromine in PDB 4er7: Crystal Structure of Human DOT1L in Complex with Inhibitor SGC0947Enzymatic activity of Crystal Structure of Human DOT1L in Complex with Inhibitor SGC0947
All present enzymatic activity of Crystal Structure of Human DOT1L in Complex with Inhibitor SGC0947:
2.1.1.43; Protein crystallography data
The structure of Crystal Structure of Human DOT1L in Complex with Inhibitor SGC0947, PDB code: 4er7
was solved by
A.K.Wernimont,
W.Tempel,
W.Yu,
A.Scopton,
Y.Li,
K.T.Nguyen,
M.Vedadi,
J.E.Bradner,
M.Schapira,
C.H.Arrowsmith,
A.M.Edwards,
C.Bountra,
P.J.Brown,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of Human DOT1L in Complex with Inhibitor SGC0947
(pdb code 4er7). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Crystal Structure of Human DOT1L in Complex with Inhibitor SGC0947, PDB code: 4er7: Jump to Bromine binding site number: 1; 2; Bromine binding site 1 out of 2 in 4er7Go back to Bromine Binding Sites List in 4er7
Bromine binding site 1 out
of 2 in the Crystal Structure of Human DOT1L in Complex with Inhibitor SGC0947
Mono view Stereo pair view
Bromine binding site 2 out of 2 in 4er7Go back to Bromine Binding Sites List in 4er7
Bromine binding site 2 out
of 2 in the Crystal Structure of Human DOT1L in Complex with Inhibitor SGC0947
Mono view Stereo pair view
Reference:
W.Yu,
E.J.Chory,
A.K.Wernimont,
W.Tempel,
A.Scopton,
A.Federation,
J.J.Marineau,
J.Qi,
D.Barsyte-Lovejoy,
J.Yi,
R.Marcellus,
R.E.Iacob,
J.R.Engen,
C.Griffin,
A.Aman,
E.Wienholds,
F.Li,
J.Pineda,
G.Estiu,
T.Shatseva,
T.Hajian,
R.Al-Awar,
J.E.Dick,
M.Vedadi,
P.J.Brown,
C.H.Arrowsmith,
J.E.Bradner,
M.Schapira.
Catalytic Site Remodelling of the DOT1L Methyltransferase By Selective Inhibitors. Nat Commun V. 3 1288 2012.
Page generated: Sat Dec 12 02:19:12 2020
ISSN: ESSN 2041-1723 PubMed: 23250418 DOI: 10.1038/NCOMMS2304 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |