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Bromine in PDB 4g1f: Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue
Enzymatic activity of Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue
All present enzymatic activity of Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue:
3.4.14.5;
3.4.14.5;
Protein crystallography data
The structure of Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue, PDB code: 4g1f
was solved by
R.J.Skene,
S.L.Gwaltney,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 40.00 / 2.90 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 121.622, 121.362, 143.257, 90.00, 114.63, 90.00 |
| R / Rfree (%) | 20.7 / 25.9 |
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue
(pdb code 4g1f). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 4 binding sites of Bromine where determined in the Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue, PDB code: 4g1f:
Jump to Bromine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Bromine where determined in the Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue, PDB code: 4g1f:
Jump to Bromine binding site number: 1; 2; 3; 4;
Bromine binding site 1 out of 4 in 4g1f
Go back to
Bromine Binding Sites List in 4g1f
Bromine binding site 1 out
of 4 in the Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue within 5.0Å range:
|
Bromine binding site 2 out of 4 in 4g1f
Go back to
Bromine Binding Sites List in 4g1f
Bromine binding site 2 out
of 4 in the Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 2 of Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue within 5.0Å range:
|
Bromine binding site 3 out of 4 in 4g1f
Go back to
Bromine Binding Sites List in 4g1f
Bromine binding site 3 out
of 4 in the Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 3 of Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue within 5.0Å range:
|
Bromine binding site 4 out of 4 in 4g1f
Go back to
Bromine Binding Sites List in 4g1f
Bromine binding site 4 out
of 4 in the Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 4 of Crystal Structure of Human Dipeptidyl Peptidase IV in Complex with A Pyridopyrimidinedione Analogue within 5.0Å range:
|
Reference:
B.Lam,
Z.Zhang,
J.A.Stafford,
R.J.Skene,
L.Shi,
S.L.Gwaltney.
Structure-Based Design of Pyridopyrimidinediones As Dipeptidyl Peptidase IV Inhibitors. Bioorg.Med.Chem.Lett. V. 22 6628 2012.
ISSN: ISSN 0960-894X
PubMed: 23025999
DOI: 10.1016/J.BMCL.2012.08.110
Page generated: Sat Dec 12 02:19:27 2020
ISSN: ISSN 0960-894X
PubMed: 23025999
DOI: 10.1016/J.BMCL.2012.08.110
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