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Bromine in PDB 4i9z: Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
Enzymatic activity of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
All present enzymatic activity of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors:
3.1.4.35;
3.1.4.35;
Protein crystallography data
The structure of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors, PDB code: 4i9z
was solved by
J.Ren,
T.Chen,
Y.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 46.30 / 2.08 |
| Space group | P 31 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.850, 74.850, 132.280, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 20.1 / 23.7 |
Other elements in 4i9z:
The structure of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
| Zinc | (Zn) | 1 atom |
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
(pdb code 4i9z). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors, PDB code: 4i9z:
In total only one binding site of Bromine was determined in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors, PDB code: 4i9z:
Bromine binding site 1 out of 1 in 4i9z
Go back to
Bromine Binding Sites List in 4i9z
Bromine binding site 1 out
of 1 in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors within 5.0Å range:
|
Reference:
X.Gong,
G.Wang,
J.Ren,
Z.Liu,
Z.Wang,
T.Chen,
X.Yang,
X.Jiang,
J.Shen,
H.Jiang,
H.A.Aisa,
Y.Xu,
J.Li.
Exploration of the 5-Bromopyrimidin-4(3H)-Ones As Potent Inhibitors of PDE5. Bioorg.Med.Chem.Lett. V. 23 4944 2013.
ISSN: ISSN 0960-894X
PubMed: 23867165
DOI: 10.1016/J.BMCL.2013.06.062
Page generated: Wed Jul 10 21:37:33 2024
ISSN: ISSN 0960-894X
PubMed: 23867165
DOI: 10.1016/J.BMCL.2013.06.062
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