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Bromine in PDB 4nlz: Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp

Enzymatic activity of Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp

All present enzymatic activity of Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp:
2.7.7.7;

Protein crystallography data

The structure of Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp, PDB code: 4nlz was solved by M.-C.Koag, K.Min, A.F.Monzingo, S.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.84 / 2.68
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 54.414, 79.438, 54.798, 90.00, 105.37, 90.00
R / Rfree (%) 20 / 29.1

Other elements in 4nlz:

The structure of Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Sodium (Na) 2 atoms

Bromine Binding Sites:

The binding sites of Bromine atom in the Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp (pdb code 4nlz). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp, PDB code: 4nlz:

Bromine binding site 1 out of 1 in 4nlz

Go back to Bromine Binding Sites List in 4nlz
Bromine binding site 1 out of 1 in the Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Structure of Human Dna Polymerase Beta Complexed with Nicked Dna Containing A Mismatched Template 8BRG and Incoming Gtp within 5.0Å range:
probe atom residue distance (Å) B Occ
T:Br6

b:38.9
occ:1.00
 BR T:BGM6 0.0 38.9 1.0
C8 T:BGM6 2.0 35.7 1.0
N9 T:BGM6 2.9 34.1 1.0
O A:HOH510 2.9 20.5 1.0
O4' T:DT7 2.9 38.8 1.0
N7 T:BGM6 2.9 33.5 1.0
C1' T:BGM6 3.2 34.1 1.0
C4' T:DT7 3.6 37.9 1.0
O4' T:BGM6 3.9 33.1 1.0
C5' T:DT7 3.9 38.8 1.0
C5 T:BGM6 4.0 32.7 1.0
C4 T:BGM6 4.0 33.5 1.0
C1' T:DT7 4.1 38.1 1.0
OH A:TYR271 4.1 29.0 1.0
O2 T:DT7 4.2 35.0 1.0
OE1 A:GLU295 4.3 34.2 1.0
C2 T:DT7 4.5 36.8 1.0
N1 T:DT7 4.5 38.5 1.0
C2' T:BGM6 4.6 35.1 1.0
N2 P:DG11 4.8 43.2 1.0
C3' T:DT7 5.0 36.7 1.0

Reference:

M.C.Koag, K.Min, S.Lee. Structural Basis For Promutagenicity of 8-Halogenated Guanine. J.Biol.Chem. V. 289 6289 2014.
ISSN: ISSN 0021-9258
PubMed: 24425881
DOI: 10.1074/JBC.M113.537803
Page generated: Wed Jul 10 22:09:17 2024

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