Bromine in PDB 4p9o: Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound

The structure of Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound, PDB code: 4p9o was solved by C.E.Naylor, C.Bagneris, B.A.Wallace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.91 / 2.89
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	80.420, 328.370, 80.390, 90.00, 90.00, 90.00
R / Rfree (%)	21.4 / 25.1

The binding sites of Bromine atom in the Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound (pdb code 4p9o). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 4 binding sites of Bromine where determined in the Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound, PDB code: 4p9o:
Jump to Bromine binding site number: 1; 2; 3; 4;

Bromine binding site 1 out of 4 in the Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound within 5.0Å range: probe atom residue distance (Å) B Occ B:Br301 b:39.9 occ:0.25 O B:HOH450 3.2 84.8 1.0 CE B:MET175 3.9 54.7 1.0 CG1 B:VAL210 4.2 96.3 1.0 CZ B:PHE214 4.5 0.5 1.0 CE1 B:PHE172 4.6 45.5 1.0 CZ B:PHE172 4.7 44.3 1.0 CG2 B:THR176 4.7 51.9 1.0 CE2 B:PHE214 4.9 0.1 1.0 CG A:MET204 4.9 68.6 1.0 CG2 A:ILE203 4.9 51.5 1.0

Bromine binding site 2 out of 4 in the Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound within 5.0Å range: probe atom residue distance (Å) B Occ B:Br304 b:38.1 occ:0.25 OG1 B:THR207 4.4 79.3 1.0 CG2 B:ILE203 4.8 50.9 1.0

Bromine binding site 3 out of 4 in the Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound within 5.0Å range: probe atom residue distance (Å) B Occ D:Br301 b:34.2 occ:0.25 CE D:MET175 3.7 54.5 1.0 CG2 D:THR176 3.9 44.4 1.0 OG1 C:THR207 4.4 73.7 1.0 CZ D:PHE172 4.4 45.1 1.0 CE1 D:PHE172 4.5 45.9 1.0 CG2 C:ILE203 4.6 46.0 1.0 CB D:THR176 4.9 47.2 1.0 CE2 D:PHE214 5.0 0.7 1.0

Bromine binding site 4 out of 4 in the Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Complex of Voltage-Gated Ion Channel in A the Presence of Channel Blocking Compound within 5.0Å range: probe atom residue distance (Å) B Occ D:Br303 b:37.4 occ:0.25 OG1 D:THR207 4.3 74.5 1.0 CG2 D:ILE203 4.4 45.0 1.0

C.Bagneris, P.G.Decaen, C.E.Naylor, D.C.Pryde, I.Nobeli, D.E.Clapham, B.A.Wallace. Prokaryotic Navms Channel As A Structural and Functional Model For Eukaryotic Sodium Channel Antagonism. Proc.Natl.Acad.Sci.Usa V. 111 8428 2014.
ISSN: ESSN 1091-6490
PubMed: 24850863
DOI: 10.1073/PNAS.1406855111