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Bromine in PDB 5czm: Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470
Enzymatic activity of Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470
All present enzymatic activity of Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470:
3.4.24.65;
3.4.24.65;
Protein crystallography data
The structure of Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470, PDB code: 5czm
was solved by
C.Rouanet-Mehouas,
L.Roselia,
L.Devel,
V.Dive,
E.A.Stura,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 28.45 / 1.30 |
| Space group | P 21 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 68.970, 63.290, 35.910, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 14.5 / 17.4 |
Other elements in 5czm:
The structure of Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470 also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
| Calcium | (Ca) | 3 atoms |
| Chlorine | (Cl) | 1 atom |
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470
(pdb code 5czm). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470, PDB code: 5czm:
In total only one binding site of Bromine was determined in the Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470, PDB code: 5czm:
Bromine binding site 1 out of 1 in 5czm
Go back to
Bromine Binding Sites List in 5czm
Bromine binding site 1 out
of 1 in the Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Crystal Structure of A Mutated Catalytic Domain of Human MMP12 in Complex with RXP470 within 5.0Å range:
|
Reference:
C.Rouanet-Mehouas,
B.Czarny,
F.Beau,
E.Cassar-Lajeunesse,
E.A.Stura,
V.Dive,
L.Devel.
Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played By the Zinc-Binding Group on Potency and Selectivity. J. Med. Chem. V. 60 403 2017.
ISSN: ISSN 1520-4804
PubMed: 27996256
DOI: 10.1021/ACS.JMEDCHEM.6B01420
Page generated: Sat Dec 12 02:25:15 2020
ISSN: ISSN 1520-4804
PubMed: 27996256
DOI: 10.1021/ACS.JMEDCHEM.6B01420
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