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Bromine in PDB 5etv: S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution
Enzymatic activity of S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution
All present enzymatic activity of S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution:
2.7.6.3;
2.7.6.3;
Protein crystallography data
The structure of S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution, PDB code: 5etv
was solved by
M.L.Dennis,
T.S.Peat,
J.D.Swarbrick,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 42.57 / 1.72 |
| Space group | P 61 |
| Cell size a, b, c (Å), α, β, γ (°) | 84.250, 84.250, 52.411, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 18.1 / 20.7 |
Other elements in 5etv:
The structure of S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution also contains other interesting chemical elements:
| Magnesium | (Mg) | 2 atoms |
Bromine Binding Sites:
The binding sites of Bromine atom in the S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution
(pdb code 5etv). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution, PDB code: 5etv:
In total only one binding site of Bromine was determined in the S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution, PDB code: 5etv:
Bromine binding site 1 out of 1 in 5etv
Go back to
Bromine Binding Sites List in 5etv
Bromine binding site 1 out
of 1 in the S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of S. Aureus 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed with Ampcpp and Inhibitor at 1.72 Angstrom Resolution within 5.0Å range:
|
Reference:
M.L.Dennis,
N.P.Pitcher,
M.D.Lee,
A.J.Debono,
Z.C.Wang,
J.R.Harjani,
R.Rahmani,
B.Cleary,
T.S.Peat,
J.B.Baell,
J.D.Swarbrick.
Structural Basis For the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase From Staphylococcus Aureus and Escherichia Coli. J.Med.Chem. V. 59 5248 2016.
ISSN: ISSN 0022-2623
PubMed: 27094768
DOI: 10.1021/ACS.JMEDCHEM.6B00002
Page generated: Wed Jul 10 23:28:47 2024
ISSN: ISSN 0022-2623
PubMed: 27094768
DOI: 10.1021/ACS.JMEDCHEM.6B00002
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