Bromine in PDB 5lxr: Structure of the Minimal RBM7 - ZCCHC8 Complex

The structure of Structure of the Minimal RBM7 - ZCCHC8 Complex, PDB code: 5lxr was solved by S.Falk, K.Finogenova, C.Benda, E.Conti, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	87.61 / 2.00
Space group	P 63 2 2
Cell size a, b, c (Å), α, β, γ (°)	79.519, 79.519, 87.609, 90.00, 90.00, 120.00
R / Rfree (%)	20.2 / 22.9

The structure of Structure of the Minimal RBM7 - ZCCHC8 Complex also contains other interesting chemical elements:

Samarium	(Sm)	4 atoms
Chlorine	(Cl)	1 atom

The binding sites of Bromine atom in the Structure of the Minimal RBM7 - ZCCHC8 Complex (pdb code 5lxr). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 4 binding sites of Bromine where determined in the Structure of the Minimal RBM7 - ZCCHC8 Complex, PDB code: 5lxr:
Jump to Bromine binding site number: 1; 2; 3; 4;

Bromine binding site 1 out of 4 in the Structure of the Minimal RBM7 - ZCCHC8 Complex


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Structure of the Minimal RBM7 - ZCCHC8 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Br104 b:0.1 occ:0.88 HE A:ARG85 2.2 0.7 1.0 HH21 A:ARG85 2.9 0.4 1.0 NE A:ARG85 3.0 98.1 1.0 HE1 A:PHE54 3.0 61.7 1.0 HG2 A:ARG85 3.3 82.6 1.0 NH2 A:ARG85 3.5 1.0 1.0 CZ A:ARG85 3.6 0.3 1.0 HB3 A:ARG85 3.8 69.2 1.0 HB2 A:PHE13 3.9 53.1 1.0 CD A:ARG85 3.9 85.4 1.0 CE1 A:PHE54 3.9 51.4 1.0 CG A:ARG85 4.0 68.9 1.0 HD2 A:ARG85 4.1 0.5 1.0 HD2 A:PHE13 4.2 62.8 1.0 HH22 A:ARG85 4.3 0.4 1.0 HA A:ARG85 4.3 69.4 1.0 CB A:ARG85 4.4 57.7 1.0 HZ A:PHE54 4.4 65.4 1.0 CZ A:PHE54 4.6 54.5 1.0 CB A:PHE13 4.7 44.3 1.0 HD3 A:ARG85 4.7 0.5 1.0 CD2 A:PHE13 4.7 52.3 1.0 HD1 A:PHE54 4.8 58.9 1.0 HG3 A:ARG85 4.8 82.6 1.0 CD1 A:PHE54 4.9 49.1 1.0 CA A:ARG85 4.9 57.8 1.0 NH1 A:ARG85 4.9 0.2 1.0 HB3 A:PHE13 4.9 53.1 1.0

Bromine binding site 2 out of 4 in the Structure of the Minimal RBM7 - ZCCHC8 Complex


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Structure of the Minimal RBM7 - ZCCHC8 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Br105 b:0.9 occ:1.00 H A:GLU23 2.3 47.6 1.0 HB A:THR22 3.0 52.2 1.0 O A:HOH243 3.0 51.5 1.0 N A:GLU23 3.2 39.7 1.0 HG3 A:GLU23 3.2 55.2 1.0 O A:HOH221 3.2 43.8 1.0 HA A:THR22 3.2 53.3 1.0 HB2 A:GLU23 3.3 54.4 1.0 HD12 A:ILE41 3.6 50.4 1.0 CB A:THR22 3.7 43.5 1.0 CA A:THR22 3.8 44.4 1.0 HG22 A:THR22 3.8 48.9 1.0 CG A:GLU23 3.8 46.0 1.0 CB A:GLU23 3.9 45.4 1.0 C A:THR22 4.0 45.0 1.0 CA A:GLU23 4.1 41.9 1.0 CD A:GLU23 4.2 35.2 1.0 OE1 A:GLU23 4.3 36.9 1.0 CG2 A:THR22 4.3 40.8 1.0 H A:GLU24 4.3 50.4 1.0 CL A:CL107 4.3 68.7 1.0 O A:HOH208 4.4 45.6 1.0 HB A:ILE41 4.4 55.2 1.0 CD1 A:ILE41 4.5 42.0 1.0 HG21 A:THR22 4.6 48.9 1.0 HG2 A:GLU23 4.7 55.2 1.0 HB3 A:GLU23 4.8 54.4 1.0 HA A:GLU23 4.8 50.2 1.0 HD13 A:ILE41 4.8 50.4 1.0 OE2 A:GLU23 4.9 37.3 1.0 OG1 A:THR22 4.9 45.0 1.0 N A:GLU24 4.9 42.0 1.0 HD11 A:ILE41 5.0 50.4 1.0

Bromine binding site 3 out of 4 in the Structure of the Minimal RBM7 - ZCCHC8 Complex


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Structure of the Minimal RBM7 - ZCCHC8 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Br106 b:0.7 occ:1.00 HG2 A:PRO42 3.2 59.4 1.0 HE2 A:PHE54 3.4 68.1 1.0 HE1 A:PHE52 3.4 60.6 1.0 HZ A:PHE52 3.6 67.5 1.0 HZ2 A:LYS50 3.7 91.5 1.0 HB3 A:PRO42 3.7 51.8 1.0 HB2 A:PRO42 3.8 51.8 1.0 CG A:PRO42 3.9 49.5 1.0 CB A:PRO42 4.0 43.2 1.0 HZ3 A:LYS50 4.0 91.5 1.0 HG3 A:PRO42 4.0 59.4 1.0 HZ A:PHE54 4.0 65.4 1.0 HZ1 A:LYS50 4.1 91.5 1.0 NZ A:LYS50 4.1 76.3 1.0 CE1 A:PHE52 4.1 50.5 1.0 CE2 A:PHE54 4.2 56.8 1.0 CZ A:PHE52 4.2 56.2 1.0 CZ A:PHE54 4.5 54.5 1.0 HG3 A:LYS50 4.8 78.0 1.0

Bromine binding site 4 out of 4 in the Structure of the Minimal RBM7 - ZCCHC8 Complex


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Structure of the Minimal RBM7 - ZCCHC8 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Br401 b:0.5 occ:1.00 HE B:ARG314 2.4 60.6 1.0 HH21 B:ARG314 3.1 60.6 1.0 HG2 B:ARG314 3.2 48.9 1.0 NE B:ARG314 3.3 50.5 1.0 O B:HOH519 3.3 58.5 1.0 HG23 B:ILE310 3.6 49.0 1.0 NH2 B:ARG314 3.8 50.5 1.0 HG3 B:ARG314 3.9 48.9 1.0 CG B:ARG314 3.9 40.7 1.0 HB2 B:PRO288 4.0 62.7 1.0 CZ B:ARG314 4.0 54.1 1.0 HD12 B:ILE310 4.0 50.3 1.0 HG2 B:PRO288 4.1 65.8 1.0 CD B:ARG314 4.2 49.3 1.0 HG21 B:ILE310 4.4 49.0 1.0 CG2 B:ILE310 4.4 40.9 1.0 HH22 B:ARG314 4.5 60.6 1.0 HG3 B:PRO288 4.6 65.8 1.0 CG B:PRO288 4.7 54.9 1.0 HG22 B:ILE310 4.7 49.0 1.0 CB B:PRO288 4.7 52.2 1.0 HD3 B:ARG314 4.7 59.1 1.0 HD2 B:ARG314 4.9 59.1 1.0 HA B:ARG314 4.9 41.9 1.0 HG2 B:MET313 5.0 39.0 1.0 CD1 B:ILE310 5.0 41.9 1.0

S.Falk, K.Finogenova, M.Melko, C.Benda, S.Lykke-Andersen, T.H.Jensen, E.Conti. Structure of the RBM7-ZCCHC8 Core of the Next Complex Reveals Connections to Splicing Factors. Nat Commun V. 7 13573 2016.
ISSN: ESSN 2041-1723
PubMed: 27905398
DOI: 10.1038/NCOMMS13573