|
Bromine in PDB 5tmm: Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with the Obhs-Asc Analog, (E)-6-(4-((1R,4S,6R)-6-((4- Bromophenoxy)Sulfonyl)-3-(4-Hydroxyphenyl)-7-Oxabicyclo[2.2.1]Hept-2- En-2-Yl)Phenyl)Hex-5-Enoic AcidProtein crystallography data
The structure of Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with the Obhs-Asc Analog, (E)-6-(4-((1R,4S,6R)-6-((4- Bromophenoxy)Sulfonyl)-3-(4-Hydroxyphenyl)-7-Oxabicyclo[2.2.1]Hept-2- En-2-Yl)Phenyl)Hex-5-Enoic Acid, PDB code: 5tmm
was solved by
J.C.Nwachukwu,
S.Srinivasan,
N.E.Bruno,
J.Nowak,
D.J.Kojetin,
O.Elemento,
J.A.Katzenellenbogen,
K.W.Nettles,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with the Obhs-Asc Analog, (E)-6-(4-((1R,4S,6R)-6-((4- Bromophenoxy)Sulfonyl)-3-(4-Hydroxyphenyl)-7-Oxabicyclo[2.2.1]Hept-2- En-2-Yl)Phenyl)Hex-5-Enoic Acid
(pdb code 5tmm). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with the Obhs-Asc Analog, (E)-6-(4-((1R,4S,6R)-6-((4- Bromophenoxy)Sulfonyl)-3-(4-Hydroxyphenyl)-7-Oxabicyclo[2.2.1]Hept-2- En-2-Yl)Phenyl)Hex-5-Enoic Acid, PDB code: 5tmm: Bromine binding site 1 out of 1 in 5tmmGo back to Bromine Binding Sites List in 5tmm
Bromine binding site 1 out
of 1 in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with the Obhs-Asc Analog, (E)-6-(4-((1R,4S,6R)-6-((4- Bromophenoxy)Sulfonyl)-3-(4-Hydroxyphenyl)-7-Oxabicyclo[2.2.1]Hept-2- En-2-Yl)Phenyl)Hex-5-Enoic Acid
Mono view Stereo pair view
Reference:
J.C.Nwachukwu,
S.Srinivasan,
N.E.Bruno,
J.Nowak,
N.J.Wright,
F.Minutolo,
E.S.Rangarajan,
T.Izard,
X.Q.Yao,
B.J.Grant,
D.J.Kojetin,
O.Elemento,
J.A.Katzenellenbogen,
K.W.Nettles.
Systems Structural Biology Analysis of Ligand Effects on Er Alpha Predicts Cellular Response to Environmental Estrogens and Anti-Hormone Therapies. Cell Chem Biol V. 24 35 2017.
Page generated: Sat Dec 12 02:30:48 2020
ISSN: ESSN 2451-9456 PubMed: 28042045 DOI: 10.1016/J.CHEMBIOL.2016.11.014 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |