Bromine in PDB 5vz4: Receptor-Growth Factor Crystal Structure at 2.20 Angstrom Resolution

The structure of Receptor-Growth Factor Crystal Structure at 2.20 Angstrom Resolution, PDB code: 5vz4 was solved by D.Lakshminarasimhan, A.White, R.K.Suto, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	71.63 / 2.20
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	75.352, 88.768, 121.293, 90.00, 90.00, 90.00
R / Rfree (%)	19.1 / 25.4

The binding sites of Bromine atom in the Receptor-Growth Factor Crystal Structure at 2.20 Angstrom Resolution (pdb code 5vz4). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Receptor-Growth Factor Crystal Structure at 2.20 Angstrom Resolution, PDB code: 5vz4:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in the Receptor-Growth Factor Crystal Structure at 2.20 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Receptor-Growth Factor Crystal Structure at 2.20 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Br201 b:0.7 occ:1.00 O A:HOH365 3.6 80.0 1.0 CD2 A:HIS18 3.7 59.3 1.0 N A:THR19 3.8 40.9 1.0 CA A:HIS18 3.9 45.1 1.0 O A:HOH311 4.0 53.8 1.0 CB A:HIS18 4.1 47.6 1.0 CG A:HIS18 4.1 59.6 1.0 NH2 A:ARG16 4.3 79.4 1.0 C A:HIS18 4.4 43.1 1.0 O A:THR19 4.5 40.6 1.0 NE2 A:HIS18 4.7 66.0 1.0 O A:LEU17 4.7 41.8 1.0 CA A:THR19 4.9 42.0 1.0 CB A:THR19 5.0 42.5 1.0

Bromine binding site 2 out of 2 in the Receptor-Growth Factor Crystal Structure at 2.20 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Receptor-Growth Factor Crystal Structure at 2.20 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Br202 b:82.6 occ:1.00 O A:HOH303 3.6 56.2 1.0 CA A:LYS69 3.7 40.8 1.0 N A:ASP71 3.7 44.4 1.0 C A:LYS69 3.7 40.4 1.0 OG1 A:THR72 3.7 61.2 1.0 CB A:ASP71 3.8 48.0 1.0 CB A:LYS69 3.9 44.9 1.0 N A:PRO70 4.0 41.0 1.0 O A:LYS69 4.1 40.6 1.0 N A:THR72 4.1 51.4 1.0 CD A:PRO70 4.2 41.4 1.0 CA A:ASP71 4.2 50.1 1.0 CG A:ASP71 4.4 48.3 1.0 OD2 A:ASP71 4.4 48.5 1.0 C A:ASP71 4.6 50.9 1.0 CG A:LYS69 4.7 54.1 1.0 C A:PRO70 4.7 41.6 1.0 CB A:THR72 4.8 52.7 1.0 CA A:PRO70 4.9 42.0 1.0 CG A:PRO70 5.0 41.6 1.0

J.Y.Hsu, S.Crawley, M.Chen, D.A.Ayupova, D.A.Lindhout, J.Higbee, A.Kutach, W.Joo, Z.Gao, D.Fu, C.To, K.Mondal, B.Li, A.Kekatpure, M.Wang, T.Laird, G.Horner, J.Chan, M.Mcentee, M.Lopez, D.Lakshminarasimhan, A.White, S.P.Wang, J.Yao, J.Yie, H.Matern, M.Solloway, R.Haldankar, T.Parsons, J.Tang, W.D.Shen, Y.Alice Chen, H.Tian, B.B.Allan. Non-Homeostatic Body Weight Regulation Through A Brainstem-Restricted Receptor For GDF15. Nature V. 550 255 2017.
ISSN: ESSN 1476-4687
PubMed: 28953886
DOI: 10.1038/NATURE24042