Bromine in PDB 5yhl: Crystal Structure of the Human Prostaglandin E Receptor EP4 in Complex with Fab and An Antagonist Br-Derivative

The structure of Crystal Structure of the Human Prostaglandin E Receptor EP4 in Complex with Fab and An Antagonist Br-Derivative, PDB code: 5yhl was solved by Y.Toyoda, K.Morimoto, R.Suno, S.Horita, S.Iwata, T.Kobayashi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.34 / 4.20
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	101.970, 392.230, 81.080, 90.00, 90.00, 90.00
R / Rfree (%)	33.3 / 35.9

The binding sites of Bromine atom in the Crystal Structure of the Human Prostaglandin E Receptor EP4 in Complex with Fab and An Antagonist Br-Derivative (pdb code 5yhl). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of the Human Prostaglandin E Receptor EP4 in Complex with Fab and An Antagonist Br-Derivative, PDB code: 5yhl:

Bromine binding site 1 out of 1 in the Crystal Structure of the Human Prostaglandin E Receptor EP4 in Complex with Fab and An Antagonist Br-Derivative


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of the Human Prostaglandin E Receptor EP4 in Complex with Fab and An Antagonist Br-Derivative within 5.0Å range: probe atom residue distance (Å) B Occ A:Br401 b:0.7 occ:1.00 BR1 A:8VL401 0.0 0.7 1.0 C02 A:8VL401 1.9 0.8 1.0 C03 A:8VL401 2.8 0.6 1.0 C30 A:8VL401 2.9 0.2 1.0 C29 A:8VL401 3.2 0.9 1.0 CG2 A:VAL320 3.4 0.1 1.0 CB A:ARG316 3.8 0.1 1.0 O A:ARG316 3.9 0.9 1.0 C A:ARG316 4.1 0.4 1.0 C04 A:8VL401 4.1 0.6 1.0 C25 A:8VL401 4.2 0.0 1.0 CA A:ARG316 4.4 0.6 1.0 C28 A:8VL401 4.5 0.2 1.0 N A:ILE317 4.6 1.0 1.0 CG A:ARG316 4.6 1.0 1.0 C05 A:8VL401 4.7 0.3 1.0 CD A:ARG316 4.8 0.8 1.0 CB A:VAL320 4.8 0.0 1.0

Y.Toyoda, K.Morimoto, R.Suno, S.Horita, K.Yamashita, K.Hirata, Y.Sekiguchi, S.Yasuda, M.Shiroishi, T.Shimizu, Y.Urushibata, Y.Kajiwara, T.Inazumi, Y.Hotta, H.Asada, T.Nakane, Y.Shiimura, T.Nakagita, K.Tsuge, S.Yoshida, T.Kuribara, T.Hosoya, Y.Sugimoto, N.Nomura, M.Sato, T.Hirokawa, M.Kinoshita, T.Murata, K.Takayama, M.Yamamoto, S.Narumiya, S.Iwata, T.Kobayashi. Ligand Binding to Human Prostaglandin E Receptor EP4AT the Lipid-Bilayer Interface. Nat. Chem. Biol. V. 15 18 2019.
ISSN: ESSN 1552-4469
PubMed: 30510193
DOI: 10.1038/S41589-018-0131-3