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Bromine in PDB 6ccm: Crystal Structure of E.Coli Phosphopantetheine Adenylyltransferase (Ppat/Coad) in Complex with 2-((3-Bromobenzyl)Amino)-5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7(4H)-OneEnzymatic activity of Crystal Structure of E.Coli Phosphopantetheine Adenylyltransferase (Ppat/Coad) in Complex with 2-((3-Bromobenzyl)Amino)-5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7(4H)-One
All present enzymatic activity of Crystal Structure of E.Coli Phosphopantetheine Adenylyltransferase (Ppat/Coad) in Complex with 2-((3-Bromobenzyl)Amino)-5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7(4H)-One:
2.7.7.3; Protein crystallography data
The structure of Crystal Structure of E.Coli Phosphopantetheine Adenylyltransferase (Ppat/Coad) in Complex with 2-((3-Bromobenzyl)Amino)-5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7(4H)-One, PDB code: 6ccm
was solved by
M.Mamo,
B.A.Appleton,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of E.Coli Phosphopantetheine Adenylyltransferase (Ppat/Coad) in Complex with 2-((3-Bromobenzyl)Amino)-5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7(4H)-One
(pdb code 6ccm). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of E.Coli Phosphopantetheine Adenylyltransferase (Ppat/Coad) in Complex with 2-((3-Bromobenzyl)Amino)-5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7(4H)-One, PDB code: 6ccm: Bromine binding site 1 out of 1 in 6ccmGo back to Bromine Binding Sites List in 6ccm
Bromine binding site 1 out
of 1 in the Crystal Structure of E.Coli Phosphopantetheine Adenylyltransferase (Ppat/Coad) in Complex with 2-((3-Bromobenzyl)Amino)-5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7(4H)-One
Mono view Stereo pair view
Reference:
R.J.Moreau,
C.K.Skepper,
B.A.Appleton,
A.Blechschmidt,
C.J.Balibar,
B.M.Benton,
J.E.Drumm,
B.Y.Feng,
M.Geng,
C.Li,
M.K.Lindvall,
A.Lingel,
Y.Lu,
M.Mamo,
W.Mergo,
V.Polyakov,
T.M.Smith,
K.Takeoka,
K.Uehara,
L.Wang,
J.R.Wei,
A.H.Weiss,
L.Xie,
W.Xu,
Q.Zhang,
J.De Vicente.
Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase From Gram-Negative Bacteria. J. Med. Chem. V. 61 3309 2018.
Page generated: Sat Dec 12 02:32:30 2020
ISSN: ISSN 1520-4804 PubMed: 29498517 DOI: 10.1021/ACS.JMEDCHEM.7B01691 |
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