Bromine in PDB 6iyx: Crystal Structure Analysis of A Eukaryotic Membrane Protein

The structure of Crystal Structure Analysis of A Eukaryotic Membrane Protein, PDB code: 6iyx was solved by Y.Zeng, X.H.Wang, F.Gao, M.Su, Y.H.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.27 / 1.80
Space group	P 63 2 2
Cell size a, b, c (Å), α, β, γ (°)	126.723, 126.723, 102.041, 90.00, 90.00, 120.00
R / Rfree (%)	20.2 / 21.2

The structure of Crystal Structure Analysis of A Eukaryotic Membrane Protein also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

The binding sites of Bromine atom in the Crystal Structure Analysis of A Eukaryotic Membrane Protein (pdb code 6iyx). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 6 binding sites of Bromine where determined in the Crystal Structure Analysis of A Eukaryotic Membrane Protein, PDB code: 6iyx:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6;

Bromine binding site 1 out of 6 in the Crystal Structure Analysis of A Eukaryotic Membrane Protein


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure Analysis of A Eukaryotic Membrane Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Br401 b:52.2 occ:1.00 O A:HOH555 3.0 36.2 0.5 O A:HOH553 3.1 32.4 1.0 CD2 A:HIS142 4.3 37.5 1.0 CB A:HIS142 4.5 34.4 1.0 CG A:HIS142 4.5 36.1 1.0 O A:HOH521 4.7 45.1 0.5 ND1 A:HIS143 4.9 40.6 1.0

Bromine binding site 2 out of 6 in the Crystal Structure Analysis of A Eukaryotic Membrane Protein


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Crystal Structure Analysis of A Eukaryotic Membrane Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Br402 b:69.7 occ:1.00 NZ A:LYS155 3.0 36.3 1.0 O A:HOH587 3.1 62.9 1.0 O A:HOH588 3.2 49.8 1.0 CA A:GLY133 3.7 34.6 1.0 CD A:LYS155 3.7 32.8 1.0 CE A:LYS155 3.9 34.6 1.0 CD2 A:HIS136 3.9 47.9 1.0 CB A:HIS136 3.9 32.8 1.0 O A:ALA132 4.0 34.2 1.0 N A:GLY133 4.0 33.5 1.0 CG A:LYS155 4.1 31.5 1.0 C A:ALA132 4.2 36.4 1.0 CG A:HIS136 4.2 46.0 1.0 CB A:ALA69 4.6 29.0 1.0 CG2 A:THR151 4.6 31.5 1.0 CB A:ALA132 4.8 34.2 1.0 C A:GLY133 4.8 34.0 1.0 O A:GLY133 4.9 31.1 1.0

Bromine binding site 3 out of 6 in the Crystal Structure Analysis of A Eukaryotic Membrane Protein


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Crystal Structure Analysis of A Eukaryotic Membrane Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Br403 b:97.7 occ:1.00 NH1 A:ARG170 3.2 47.3 1.0 NE2 A:GLN167 3.3 59.3 1.0 NH2 A:ARG170 3.4 40.1 1.0 CZ A:ARG170 3.7 43.6 1.0 CD A:PRO41 3.9 57.6 1.0 CG A:PRO41 4.1 61.1 1.0 CG A:GLN167 4.1 46.7 1.0 CG1 A:VAL172 4.1 49.6 1.0 CD A:GLN167 4.2 49.3 1.0 CD A:ARG174 4.7 81.7 1.0 NE A:ARG174 4.7 93.6 1.0 CB A:PRO41 4.8 60.4 1.0 CB A:VAL172 4.9 46.6 1.0 CG2 A:VAL172 4.9 48.9 1.0

Bromine binding site 4 out of 6 in the Crystal Structure Analysis of A Eukaryotic Membrane Protein


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Crystal Structure Analysis of A Eukaryotic Membrane Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Br404 b:83.7 occ:1.00 N A:PHE52 3.3 39.0 1.0 CD A:PRO51 3.5 48.7 1.0 CB A:PHE52 3.5 43.2 1.0 N A:PRO51 3.7 45.8 1.0 CG A:PRO51 3.7 52.7 1.0 C A:SER50 4.0 42.0 1.0 CA A:PHE52 4.0 39.5 1.0 CA A:SER50 4.1 41.9 1.0 C A:PRO51 4.3 42.3 1.0 CA A:PRO51 4.4 45.2 1.0 O A:SER50 4.6 42.0 1.0 CB A:PRO51 4.6 46.8 1.0 N A:ALA53 4.9 38.6 1.0 O A:LYS49 4.9 49.2 1.0 CG A:PHE52 4.9 41.5 1.0

Bromine binding site 5 out of 6 in the Crystal Structure Analysis of A Eukaryotic Membrane Protein


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of Crystal Structure Analysis of A Eukaryotic Membrane Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Br405 b:72.3 occ:1.00 O A:HOH589 2.8 48.7 1.0 NZ A:LYS155 3.0 36.3 1.0 CB A:ALA132 3.4 34.2 1.0 CE A:LYS155 3.7 34.6 1.0 CE1 A:TYR66 3.8 39.5 1.0 CG A:LYS129 3.8 35.0 1.0 OH A:TYR66 3.9 54.7 1.0 CA A:LYS129 4.0 33.0 1.0 O A:HOH567 4.1 78.0 1.0 CZ A:TYR66 4.3 45.4 1.0 CB A:LYS129 4.4 32.4 1.0 O A:LYS129 4.6 30.9 1.0 O A:ARG128 4.7 33.9 1.0 O A:HOH584 4.7 58.6 1.0 O A:HOH588 4.8 49.8 1.0 N A:LYS129 4.8 31.3 1.0 CD1 A:TYR66 4.8 34.3 1.0 C A:LYS129 4.8 32.4 1.0 CA A:ALA132 4.9 32.6 1.0

Bromine binding site 6 out of 6 in the Crystal Structure Analysis of A Eukaryotic Membrane Protein


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 6 of Crystal Structure Analysis of A Eukaryotic Membrane Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Br406 b:0.4 occ:1.00 O A:HOH558 2.5 50.0 1.0 NH2 A:ARG126 3.4 46.2 1.0 NZ A:LYS224 3.8 68.2 1.0 CG A:PRO186 3.9 57.2 1.0 O A:HOH581 4.1 59.0 1.0 CE A:LYS224 4.1 68.2 1.0 O A:HOH551 4.1 58.4 1.0 NZ A:LYS122 4.1 55.0 1.0 CB A:PRO186 4.1 52.4 1.0 CE A:LYS122 4.2 53.3 1.0 NH1 A:ARG126 4.3 47.6 1.0 CZ A:ARG126 4.4 49.5 1.0 O A:HOH572 4.7 50.0 1.0

X.H.Wang, M.Su, F.Gao, W.Xie, Y.Zeng, D.L.Li, X.L.Liu, H.Zhao, L.Qin, F.Li, Q.Liu, O.B.Clarke, S.M.Lam, G.H.Shui, W.A.Hendrickson, Y.H.Chen. Structural Basis For Activity of Tric Counter-Ion Channels in Calcium Release. Proc.Natl.Acad.Sci.Usa V. 116 4238 2019.
ISSN: ESSN 1091-6490
PubMed: 30770441
DOI: 10.1073/PNAS.1817271116