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Bromine in PDB 6q3c: CDK2 in Complex with FRAGLITE1Enzymatic activity of CDK2 in Complex with FRAGLITE1
All present enzymatic activity of CDK2 in Complex with FRAGLITE1:
2.7.11.22; Protein crystallography data
The structure of CDK2 in Complex with FRAGLITE1, PDB code: 6q3c
was solved by
D.J.Wood,
M.P.Martin,
M.E.M.Noble,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the CDK2 in Complex with FRAGLITE1
(pdb code 6q3c). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the CDK2 in Complex with FRAGLITE1, PDB code: 6q3c: Jump to Bromine binding site number: 1; 2; Bromine binding site 1 out of 2 in 6q3cGo back to Bromine Binding Sites List in 6q3c
Bromine binding site 1 out
of 2 in the CDK2 in Complex with FRAGLITE1
Mono view Stereo pair view
Bromine binding site 2 out of 2 in 6q3cGo back to Bromine Binding Sites List in 6q3c
Bromine binding site 2 out
of 2 in the CDK2 in Complex with FRAGLITE1
Mono view Stereo pair view
Reference:
D.J.Wood,
J.D.Lopez-Fernandez,
L.E.Knight,
I.Al-Khawaldeh,
C.Gai,
S.Lin,
M.P.Martin,
D.C.Miller,
C.Cano,
J.A.Endicott,
I.R.Hardcastle,
M.E.M.Noble,
M.J.Waring.
Fraglites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem. V. 62 3741 2019.
Page generated: Sat Dec 12 02:35:47 2020
ISSN: ISSN 0022-2623 PubMed: 30860382 DOI: 10.1021/ACS.JMEDCHEM.9B00304 |
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