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Bromine in PDB 6qdg: Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169

Enzymatic activity of Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169

All present enzymatic activity of Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169:
2.3.1.97;

Protein crystallography data

The structure of Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169, PDB code: 6qdg was solved by J.A.Brannigan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.75 / 1.98
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 48.598, 91.202, 53.344, 90.00, 113.96, 90.00
R / Rfree (%) 18.6 / 25.4

Other elements in 6qdg:

The structure of Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169 also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Bromine Binding Sites:

The binding sites of Bromine atom in the Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169 (pdb code 6qdg). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169, PDB code: 6qdg:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in 6qdg

Go back to Bromine Binding Sites List in 6qdg
Bromine binding site 1 out of 2 in the Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1003

b:86.3
occ:0.50
BR A:HXN1003 0.0 86.3 0.5
BR A:HXN1003 0.1 93.3 0.5
C14 A:HXN1003 1.9 72.0 0.5
C14 A:HXN1003 1.9 75.7 0.5
C13 A:HXN1003 2.8 67.7 0.5
C13 A:HXN1003 2.8 70.6 0.5
C15 A:HXN1003 2.9 66.3 0.5
C15 A:HXN1003 2.9 69.7 0.5
O A:ASP396 3.1 51.4 1.0
O A:HOH1271 3.1 53.7 1.0
N A:ASP396 3.5 46.4 1.0
CA A:GLY395 3.8 34.5 1.0
CB A:TYR217 3.9 28.9 0.5
CB A:TYR217 4.0 23.3 0.5
C A:ASP396 4.0 50.0 1.0
C A:GLY395 4.0 44.4 1.0
C12 A:HXN1003 4.1 63.1 0.5
C12 A:HXN1003 4.1 65.2 0.5
CG A:TYR217 4.2 34.0 0.5
C16 A:HXN1003 4.2 63.9 0.5
C16 A:HXN1003 4.2 66.6 0.5
CD1 A:TYR217 4.2 35.7 0.5
CA A:ASP396 4.3 50.7 1.0
CG A:TYR217 4.6 23.6 0.5
C9 A:HXN1003 4.6 71.5 0.5
C9 A:HXN1003 4.7 66.5 0.5
C17 A:HXN1003 4.7 61.1 0.5
C17 A:HXN1003 4.7 63.5 0.5
CB A:ASP396 4.8 58.4 1.0
CD2 A:TYR217 4.9 34.6 0.5
N A:GLY395 4.9 38.5 1.0
CD1 A:TYR217 5.0 23.8 0.5

Bromine binding site 2 out of 2 in 6qdg

Go back to Bromine Binding Sites List in 6qdg
Bromine binding site 2 out of 2 in the Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Leishmania Major N-Myristoyltransferase in Complex with Quinazoline Inhibitor Imp-0000169 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1003

b:93.3
occ:0.50
BR A:HXN1003 0.0 93.3 0.5
BR A:HXN1003 0.1 86.3 0.5
C14 A:HXN1003 1.9 72.0 0.5
C14 A:HXN1003 1.9 75.7 0.5
C13 A:HXN1003 2.8 67.7 0.5
C13 A:HXN1003 2.8 70.6 0.5
C15 A:HXN1003 2.9 66.3 0.5
C15 A:HXN1003 2.9 69.7 0.5
O A:HOH1271 3.1 53.7 1.0
O A:ASP396 3.1 51.4 1.0
N A:ASP396 3.6 46.4 1.0
CA A:GLY395 3.9 34.5 1.0
CB A:TYR217 4.0 28.9 0.5
C A:ASP396 4.1 50.0 1.0
C A:GLY395 4.1 44.4 1.0
CB A:TYR217 4.1 23.3 0.5
C12 A:HXN1003 4.1 63.1 0.5
C12 A:HXN1003 4.1 65.2 0.5
C16 A:HXN1003 4.2 63.9 0.5
C16 A:HXN1003 4.2 66.6 0.5
CG A:TYR217 4.2 34.0 0.5
CA A:ASP396 4.3 50.7 1.0
CD1 A:TYR217 4.3 35.7 0.5
C9 A:HXN1003 4.6 71.5 0.5
CG A:TYR217 4.6 23.6 0.5
C9 A:HXN1003 4.7 66.5 0.5
C17 A:HXN1003 4.7 61.1 0.5
C17 A:HXN1003 4.7 63.5 0.5
CB A:ASP396 4.8 58.4 1.0
N A:GLY395 5.0 38.5 1.0
CD2 A:TYR217 5.0 34.6 0.5

Reference:

J.A.Brannigan, J.A.Brannigan. N/A N/A.
Page generated: Thu Jul 11 02:31:41 2024

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