Bromine in PDB 6rlq: Crystal Structure of the Human PRMT5:MEP50 Complex with JNJ45031882

All present enzymatic activity of Crystal Structure of the Human PRMT5:MEP50 Complex with JNJ45031882:
2.1.1.320;

The structure of Crystal Structure of the Human PRMT5:MEP50 Complex with JNJ45031882, PDB code: 6rlq was solved by D.G.Brown, C.M.Robinson, V.Pande, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	89.30 / 2.53
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	101.132, 137.854, 178.617, 90.00, 90.00, 90.00
R / Rfree (%)	23 / 29.9

The binding sites of Bromine atom in the Crystal Structure of the Human PRMT5:MEP50 Complex with JNJ45031882 (pdb code 6rlq). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of the Human PRMT5:MEP50 Complex with JNJ45031882, PDB code: 6rlq:

Bromine binding site 1 out of 1 in the Crystal Structure of the Human PRMT5:MEP50 Complex with JNJ45031882


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of the Human PRMT5:MEP50 Complex with JNJ45031882 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br701 b:48.4 occ:1.00 BR1 A:K8N701 0.0 48.4 1.0 C17 A:K8N701 1.9 34.6 1.0 C16 A:K8N701 2.8 31.8 1.0 O A:SER578 2.9 29.2 1.0 C18 A:K8N701 2.9 36.7 1.0 N5 A:K8N701 3.1 36.1 1.0 CD1 A:TRP579 3.5 21.8 1.0 C A:SER578 3.5 25.8 1.0 NE1 A:TRP579 3.7 21.1 1.0 CG A:TRP579 3.8 21.8 1.0 N A:TRP579 4.1 23.8 1.0 C15 A:K8N701 4.1 30.4 1.0 CB A:SER578 4.1 26.5 1.0 N6 A:K8N701 4.1 34.7 1.0 CA A:TRP579 4.2 22.4 1.0 CE1 A:PHE327 4.2 23.8 1.0 CE2 A:TRP579 4.2 22.3 1.0 CA A:SER578 4.3 26.5 1.0 CD2 A:TRP579 4.3 22.7 1.0 CD1 A:PHE327 4.5 23.4 1.0 CB A:TRP579 4.5 22.1 1.0 O A:HOH826 4.6 29.5 1.0 C19 A:K8N701 4.6 33.4 1.0 O A:HOH806 4.8 58.3 1.0 OG A:SER578 4.8 27.1 1.0 CZ A:PHE327 4.9 24.6 1.0

D.G.Brown, C.M.Robinson, V.Pande. Crystal Structure of the Human PRMT5:MEP50 Complex with JNJ45031882 To Be Published.