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Bromine in PDB 6uif: Discovery of Fragment-Inspired Heterocyclic Benzenesulfonmides As Inhibitors of the WDR5-Myc InteractionProtein crystallography data
The structure of Discovery of Fragment-Inspired Heterocyclic Benzenesulfonmides As Inhibitors of the WDR5-Myc Interaction, PDB code: 6uif
was solved by
B.Zhao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6uif:
The structure of Discovery of Fragment-Inspired Heterocyclic Benzenesulfonmides As Inhibitors of the WDR5-Myc Interaction also contains other interesting chemical elements:
Bromine Binding Sites:
The binding sites of Bromine atom in the Discovery of Fragment-Inspired Heterocyclic Benzenesulfonmides As Inhibitors of the WDR5-Myc Interaction
(pdb code 6uif). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Discovery of Fragment-Inspired Heterocyclic Benzenesulfonmides As Inhibitors of the WDR5-Myc Interaction, PDB code: 6uif: Jump to Bromine binding site number: 1; 2; Bromine binding site 1 out of 2 in 6uifGo back to Bromine Binding Sites List in 6uif
Bromine binding site 1 out
of 2 in the Discovery of Fragment-Inspired Heterocyclic Benzenesulfonmides As Inhibitors of the WDR5-Myc Interaction
Mono view Stereo pair view
Bromine binding site 2 out of 2 in 6uifGo back to Bromine Binding Sites List in 6uif
Bromine binding site 2 out
of 2 in the Discovery of Fragment-Inspired Heterocyclic Benzenesulfonmides As Inhibitors of the WDR5-Myc Interaction
Mono view Stereo pair view
Reference:
S.Chacon Simon,
F.Wang,
L.R.Thomas,
J.Phan,
B.Zhao,
E.T.Olejniczak,
J.D.Macdonald,
J.G.Shaw,
C.Schlund,
W.G.Payne,
J.Creighton,
S.Stauffer,
A.G.Waterson,
W.P.Tansey,
S.W.Fesik.
Discovery of Wd Repeat-Containing Protein 5 (WDR5)-Myc Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem. 2020.
Page generated: Sat Dec 12 02:39:38 2020
ISSN: ISSN 0022-2623 PubMed: 32223236 DOI: 10.1021/ACS.JMEDCHEM.0C00224 |
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