Bromine in PDB 6xlx: Crystal Structure of Cancer-Associated G301D Mutant of U2AF65 Bound to Adml Splice Site

The structure of Crystal Structure of Cancer-Associated G301D Mutant of U2AF65 Bound to Adml Splice Site, PDB code: 6xlx was solved by D.Maji, J.L.Jenkins, C.L.Kielkopf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.71 / 1.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	43.492, 61.875, 77.421, 90.00, 90.00, 90.00
R / Rfree (%)	16.3 / 19.4

The binding sites of Bromine atom in the Crystal Structure of Cancer-Associated G301D Mutant of U2AF65 Bound to Adml Splice Site (pdb code 6xlx). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of Cancer-Associated G301D Mutant of U2AF65 Bound to Adml Splice Site, PDB code: 6xlx:

Bromine binding site 1 out of 1 in the Crystal Structure of Cancer-Associated G301D Mutant of U2AF65 Bound to Adml Splice Site


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of Cancer-Associated G301D Mutant of U2AF65 Bound to Adml Splice Site within 5.0Å range: probe atom residue distance (Å) B Occ B:Br7 b:30.0 occ:1.00 BR B:BRU7 0.0 30.0 1.0 C5 B:BRU7 1.9 24.9 1.0 C6 B:BRU7 2.9 24.8 1.0 OP2 B:U6 2.9 22.0 1.0 C4 B:BRU7 2.9 21.9 1.0 H6 B:BRU7 2.9 29.8 1.0 O4 B:BRU7 3.1 22.7 1.0 O5' B:U6 3.3 21.4 1.0 H3' B:U6 3.5 31.5 1.0 P B:U6 3.7 23.7 1.0 CZ A:TYR152 3.8 21.4 1.0 O B:HOH119 3.8 24.9 1.0 HE1 A:HIS230 3.8 33.6 1.0 CE1 A:TYR152 3.8 22.3 1.0 HG3 A:ARG227 3.8 25.7 1.0 HE1 A:TYR152 3.9 26.7 1.0 OH A:TYR152 4.0 24.4 1.0 O B:HOH117 4.0 23.4 1.0 H2' B:U6 4.1 32.3 1.0 N1 B:BRU7 4.1 24.5 1.0 N3 B:BRU7 4.2 23.8 1.0 CE2 A:TYR152 4.2 21.9 1.0 O B:HOH113 4.3 24.2 1.0 CE1 A:HIS230 4.3 28.0 1.0 HH A:TYR152 4.3 29.2 1.0 CD1 A:TYR152 4.3 19.6 1.0 C3' B:U6 4.3 26.2 1.0 NE2 A:HIS230 4.4 28.2 1.0 C5' B:U6 4.5 24.9 1.0 H5'' B:U6 4.5 30.0 1.0 OP1 B:U6 4.5 24.8 1.0 HE2 A:TYR152 4.6 26.3 1.0 O A:HOH469 4.6 29.7 1.0 C2' B:U6 4.6 26.9 1.0 C2 B:BRU7 4.7 24.4 1.0 CD2 A:TYR152 4.7 19.6 1.0 HB2 A:ARG227 4.7 27.1 1.0 HD1 A:TYR152 4.7 23.6 1.0 CG A:TYR152 4.7 21.7 1.0 CG A:ARG227 4.8 21.4 1.0 O5' B:BRU7 4.9 27.9 1.0 O3' B:U5 5.0 24.7 1.0

D.Maji, J.L.Jenkins, C.L.Kielkopf. Crystal Structure of Cancer-Associated G301D Mutant of U2AF65 Bound to Adml Splice Site To Be Published.