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Atomistry » Bromine » PDB 6yod-7akh » 7ake | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 6yod-7akh » 7ake » |
Bromine in PDB 7ake: Structure of DYRK1A in Complex with Compound 58Enzymatic activity of Structure of DYRK1A in Complex with Compound 58
All present enzymatic activity of Structure of DYRK1A in Complex with Compound 58:
2.7.12.1; Protein crystallography data
The structure of Structure of DYRK1A in Complex with Compound 58, PDB code: 7ake
was solved by
P.Dokurno,
A.E.Surgenor,
A.Kotschy,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7ake:
The structure of Structure of DYRK1A in Complex with Compound 58 also contains other interesting chemical elements:
Bromine Binding Sites:
The binding sites of Bromine atom in the Structure of DYRK1A in Complex with Compound 58
(pdb code 7ake). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Structure of DYRK1A in Complex with Compound 58, PDB code: 7ake: Jump to Bromine binding site number: 1; 2; Bromine binding site 1 out of 2 in 7akeGo back to Bromine Binding Sites List in 7ake
Bromine binding site 1 out
of 2 in the Structure of DYRK1A in Complex with Compound 58
Mono view Stereo pair view
Bromine binding site 2 out of 2 in 7akeGo back to Bromine Binding Sites List in 7ake
Bromine binding site 2 out
of 2 in the Structure of DYRK1A in Complex with Compound 58
Mono view Stereo pair view
Reference:
C.Weber,
M.Sipos,
A.Paczal,
B.Balint,
V.Kun,
N.Foloppe,
P.Dokurno,
A.J.Massey,
D.L.Walmsley,
R.E.Hubbard,
J.Murray,
K.Benwell,
T.Edmonds,
D.Demarles,
A.Bruno,
M.Burbridge,
F.Cruzalegui,
A.Kotschy.
Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J.Med.Chem. 2021.
Page generated: Sat Jul 10 09:55:21 2021
ISSN: ISSN 0022-2623 PubMed: 33975430 DOI: 10.1021/ACS.JMEDCHEM.1C00023 |
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