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Atomistry » Bromine » PDB 7gpx-7l1e » 7kib | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 7gpx-7l1e » 7kib » |
Bromine in PDB 7kib: PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4Enzymatic activity of PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4
All present enzymatic activity of PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4:
2.1.1.320; Protein crystallography data
The structure of PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4, PDB code: 7kib
was solved by
R.L.Palte,
R.P.Hayes,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7kib:
The structure of PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4 also contains other interesting chemical elements:
Bromine Binding Sites:
The binding sites of Bromine atom in the PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4
(pdb code 7kib). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4, PDB code: 7kib: Bromine binding site 1 out of 1 in 7kibGo back to![]() ![]()
Bromine binding site 1 out
of 1 in the PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4
![]() Mono view ![]() Stereo pair view
Reference:
R.V.Quiroz,
M.H.Reutershan,
S.E.Schneider,
D.Sloman,
B.M.Lacey,
B.M.Swalm,
C.S.Yeung,
C.Gibeau,
D.S.Spellman,
D.A.Rankic,
D.Chen,
D.Witter,
D.Linn,
E.Munsell,
G.Feng,
H.Xu,
J.M.E.Hughes,
J.Lim,
J.Sauri,
K.Geddes,
M.Wan,
M.S.Mansueto,
N.E.Follmer,
P.S.Fier,
P.Siliphaivanh,
P.Daublain,
R.L.Palte,
R.P.Hayes,
S.Lee,
S.Kawamura,
S.Silverman,
S.Sanyal,
T.J.Henderson,
Y.Ye,
Y.Gao,
B.Nicholson,
M.R.Machacek.
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors For the Treatment of Cancer. J.Med.Chem. V. 64 3911 2021.
Page generated: Thu Jul 11 04:01:41 2024
ISSN: ISSN 0022-2623 PubMed: 33755451 DOI: 10.1021/ACS.JMEDCHEM.0C02083 |
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