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Bromine in PDB 7kic: PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34Enzymatic activity of PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34
All present enzymatic activity of PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34:
2.1.1.320; Protein crystallography data
The structure of PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34, PDB code: 7kic
was solved by
R.L.Palte,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34
(pdb code 7kic). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34, PDB code: 7kic: Bromine binding site 1 out of 1 in 7kicGo back to Bromine Binding Sites List in 7kic
Bromine binding site 1 out
of 1 in the PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34
Mono view Stereo pair view
Reference:
R.V.Quiroz,
M.H.Reutershan,
S.E.Schneider,
D.Sloman,
B.M.Lacey,
B.M.Swalm,
C.S.Yeung,
C.Gibeau,
D.S.Spellman,
D.A.Rankic,
D.Chen,
D.Witter,
D.Linn,
E.Munsell,
G.Feng,
H.Xu,
J.M.E.Hughes,
J.Lim,
J.Sauri,
K.Geddes,
M.Wan,
M.S.Mansueto,
N.E.Follmer,
P.S.Fier,
P.Siliphaivanh,
P.Daublain,
R.L.Palte,
R.P.Hayes,
S.Lee,
S.Kawamura,
S.Silverman,
S.Sanyal,
T.J.Henderson,
Y.Ye,
Y.Gao,
B.Nicholson,
M.R.Machacek.
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors For the Treatment of Cancer. J.Med.Chem. V. 64 3911 2021.
Page generated: Sat Jul 10 09:59:09 2021
ISSN: ISSN 0022-2623 PubMed: 33755451 DOI: 10.1021/ACS.JMEDCHEM.0C02083 |
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