Atomistry » Bromine » PDB 7km9-7o21 » 7mda
Atomistry »
  Bromine »
    PDB 7km9-7o21 »
      7mda »

Bromine in PDB 7mda: Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1

Enzymatic activity of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1

All present enzymatic activity of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1:
2.5.1.48; 4.4.1.1; 4.4.1.8;

Protein crystallography data

The structure of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1, PDB code: 7mda was solved by A.Nuthanakanti, A.Serganov, A.Kaushik, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.95 / 2.24
Space group I 41 2 2
Cell size a, b, c (Å), α, β, γ (°) 105.227, 105.227, 287.668, 90, 90, 90
R / Rfree (%) 18.4 / 21.1

Other elements in 7mda:

The structure of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1 also contains other interesting chemical elements:

Sodium (Na) 2 atoms

Bromine Binding Sites:

The binding sites of Bromine atom in the Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1 (pdb code 7mda). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1, PDB code: 7mda:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in 7mda

Go back to Bromine Binding Sites List in 7mda
Bromine binding site 1 out of 2 in the Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Br401

b:85.0
occ:0.44
ND1 H:HIS12 3.7 74.6 1.0
CB H:HIS12 4.0 69.8 1.0
O H:SER54 4.0 54.4 1.0
C H:SER54 4.2 50.1 1.0
CB H:SER54 4.2 50.8 1.0
O H:HOH593 4.2 58.9 1.0
CG H:HIS12 4.3 75.3 1.0
N H:SER55 4.4 47.8 1.0
CB H:SER58 4.5 53.0 1.0
CA H:SER55 4.5 48.1 1.0
OG H:SER58 4.7 57.3 1.0
CE1 H:HIS12 4.8 63.4 1.0
CA H:SER54 4.8 52.1 1.0
O H:HIS12 4.9 64.9 1.0

Bromine binding site 2 out of 2 in 7mda

Go back to Bromine Binding Sites List in 7mda
Bromine binding site 2 out of 2 in the Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase Holoenzyme Y103A Mutant Co-Crystallized with NL1 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Br402

b:82.1
occ:0.46
BR H:LB6402 0.0 82.1 0.5
C6 H:LB6402 1.9 74.0 0.3
C7 H:LB6402 2.8 75.7 1.0
C5 H:LB6402 2.8 70.7 1.0
N H:SER1 3.3 78.9 1.0
CA H:LYS6 3.7 60.1 1.0
N H:LYS6 4.0 59.4 1.0
CG2 H:THR5 4.1 52.1 1.0
C8 H:LB6402 4.1 76.7 0.7
C4 H:LB6402 4.2 78.0 0.9
CB H:LYS6 4.2 62.1 1.0
C H:THR5 4.3 57.4 1.0
O H:THR5 4.3 56.0 1.0
CB H:HIS9 4.4 53.9 1.0
CB H:THR5 4.7 51.2 1.0
C9 H:LB6402 4.7 75.3 0.5
CA H:SER1 4.8 74.4 1.0
CG H:LYS6 4.8 70.4 1.0
N H:GLY10 4.9 55.4 1.0
C H:LYS6 4.9 58.8 1.0
C H:HIS9 4.9 61.3 1.0

Reference:

K.Shatalin, A.Nuthanakanti, A.Kaushik, D.Shishov, A.Peselis, I.Shamovsky, B.Pani, M.Lechpammer, N.Vasilyev, E.Shatalina, D.Rebatchouk, A.Mironov, P.Fedichev, A.Serganov, E.Nudler. Inhibitors of Bacterial H 2 S Biogenesis Targeting Antibiotic Resistance and Tolerance. Science V. 372 1169 2021.
ISSN: ESSN 1095-9203
PubMed: 34112687
DOI: 10.1126/SCIENCE.ABD8377
Page generated: Thu Jul 11 04:06:28 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy