Bromine in PDB 7mi6: Yeast Dynein Motor Domain in the Presence of A Pyrazolo-Pyrimidinone- Based Compound, Model 1

Other elements in 7mi6:

The structure of Yeast Dynein Motor Domain in the Presence of A Pyrazolo-Pyrimidinone- Based Compound, Model 1 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms
Magnesium (Mg) 1 atom

Bromine Binding Sites:

The binding sites of Bromine atom in the Yeast Dynein Motor Domain in the Presence of A Pyrazolo-Pyrimidinone- Based Compound, Model 1 (pdb code 7mi6). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Yeast Dynein Motor Domain in the Presence of A Pyrazolo-Pyrimidinone- Based Compound, Model 1, PDB code: 7mi6:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in 7mi6

Go back to Bromine Binding Sites List in 7mi6
Bromine binding site 1 out of 2 in the Yeast Dynein Motor Domain in the Presence of A Pyrazolo-Pyrimidinone- Based Compound, Model 1


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Yeast Dynein Motor Domain in the Presence of A Pyrazolo-Pyrimidinone- Based Compound, Model 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br4201

b:109.3
occ:1.00
BR22 A:ZG74201 0.0 109.3 1.0
C21 A:ZG74201 1.9 109.3 1.0
C23 A:ZG74201 2.9 109.3 1.0
C20 A:ZG74201 2.9 109.3 1.0
CA A:PRO2420 3.6 94.5 1.0
CB A:PRO2420 3.8 94.5 1.0
N A:GLY2421 3.9 95.2 1.0
NH1 A:ARG2620 4.0 92.1 1.0
ND2 A:ASN2536 4.0 108.9 1.0
C A:PRO2420 4.1 94.5 1.0
NZ A:LYS2424 4.1 89.6 1.0
C19 A:ZG74201 4.2 109.3 1.0
C24 A:ZG74201 4.2 109.3 1.0
OD1 A:ASN2536 4.2 108.9 1.0
ND2 A:ASN2910 4.5 79.3 1.0
OE2 A:GLU2488 4.6 96.9 1.0
CG A:ASN2536 4.6 108.9 1.0
CE A:LYS2424 4.6 89.6 1.0
NH2 A:ARG2620 4.7 92.1 1.0
C25 A:ZG74201 4.7 109.3 1.0
CZ A:ARG2620 4.8 92.1 1.0
N A:PRO2420 4.8 94.5 1.0

Bromine binding site 2 out of 2 in 7mi6

Go back to Bromine Binding Sites List in 7mi6
Bromine binding site 2 out of 2 in the Yeast Dynein Motor Domain in the Presence of A Pyrazolo-Pyrimidinone- Based Compound, Model 1


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Yeast Dynein Motor Domain in the Presence of A Pyrazolo-Pyrimidinone- Based Compound, Model 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br4202

b:89.6
occ:1.00
BR22 A:ZG74202 0.0 89.6 1.0
C21 A:ZG74202 1.9 89.6 1.0
C23 A:ZG74202 2.8 89.6 1.0
C20 A:ZG74202 2.9 89.6 1.0
O A:ALA2761 3.1 78.4 1.0
NZ A:LYS2766 3.2 70.1 1.0
CD A:LYS2766 3.6 70.1 1.0
CE A:LYS2766 3.6 70.1 1.0
CA A:SER2762 3.6 82.4 1.0
C A:ALA2761 4.0 78.4 1.0
CB A:CYS2892 4.0 88.3 1.0
C24 A:ZG74202 4.2 89.6 1.0
N A:SER2762 4.2 82.4 1.0
C19 A:ZG74202 4.2 89.6 1.0
CB A:SER2762 4.3 82.4 1.0
CA A:CYS2892 4.3 88.3 1.0
OG A:SER2762 4.4 82.4 1.0
CG A:LYS2766 4.4 70.1 1.0
C A:SER2762 4.6 82.4 1.0
N A:ARG2763 4.7 83.3 1.0
C25 A:ZG74202 4.7 89.6 1.0
N A:CYS2892 4.8 88.3 1.0
CB A:LYS2766 4.9 70.1 1.0

Reference:

C.C.Santarossa, K.J.Mickolajczyk, J.B.Steinman, L.Urnavicius, N.Chen, Y.Hirata, Y.Fukase, N.Coudray, D.C.Ekiert, G.Bhabha, T.M.Kapoor. Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors Cell Chem Biol 2021.
ISSN: ESSN 2451-9456
DOI: 10.1016/J.CHEMBIOL.2021.04.024
Page generated: Sat Jul 10 09:59:26 2021

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