Bromine in PDB 7t0a: Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F

Enzymatic activity of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F

All present enzymatic activity of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F:
2.5.1.58;

Protein crystallography data

The structure of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F, PDB code: 7t0a was solved by Y.Wang, Y.Shi, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.93 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 141.21, 141.21, 129.822, 90, 90, 90
R / Rfree (%) 18.7 / 21.3

Other elements in 7t0a:

The structure of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F also contains other interesting chemical elements:

Zinc (Zn) 1 atom
Fluorine (F) 3 atoms

Bromine Binding Sites:

The binding sites of Bromine atom in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F (pdb code 7t0a). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F, PDB code: 7t0a:

Bromine binding site 1 out of 1 in 7t0a

Go back to Bromine Binding Sites List in 7t0a
Bromine binding site 1 out of 1 in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Br605

b:53.6
occ:1.00
 BR23 B:XMY605 0.0 53.6 1.0
C22 B:XMY605 2.0 35.5 1.0
C21 B:XMY605 2.9 37.8 1.0
C24 B:XMY605 2.9 30.1 1.0
CA B:GLY268 3.5 21.5 1.0
C B:GLY268 3.6 29.7 1.0
C27 B:XMY605 3.7 33.0 1.0
O32 B:XMY605 3.7 38.0 1.0
O B:GLY268 3.9 23.4 1.0
CG B:ARG197 3.9 37.5 1.0
CD B:ARG197 3.9 30.0 1.0
N B:TYR269 4.2 23.9 1.0
C28 B:XMY605 4.2 45.3 1.0
C20 B:XMY605 4.2 37.8 1.0
C25 B:XMY605 4.2 34.5 1.0
CE1 B:TYR269 4.4 34.3 1.0
CZ2 B:TRP329 4.4 30.7 1.0
CD1 B:TYR269 4.5 27.3 1.0
SG B:CYS272 4.5 30.2 1.0
CH2 B:TRP329 4.5 28.6 1.0
CE2 B:TRP329 4.6 27.5 1.0
C19 B:XMY605 4.7 41.4 1.0
N B:GLY268 4.7 22.5 1.0
CZ B:TYR269 4.8 30.1 1.0
CZ3 B:TRP329 4.8 27.4 1.0
C26 B:XMY605 4.8 41.5 1.0
F36 B:XMY605 4.8 52.3 1.0
C33 B:XMY605 4.9 40.5 1.0
O09 B:XMY605 4.9 33.2 1.0
CD2 B:TRP329 4.9 22.1 1.0
CG B:TYR269 4.9 25.3 1.0
CA B:TYR269 4.9 23.4 1.0
CE3 B:TRP329 5.0 22.9 1.0

Reference:

Y.Wang, F.Xu, C.B.Nichols, Y.Shi, H.W.Hellinga, J.A.Alspaugh, M.D.Distefano, L.S.Beese. Structure-Guided Discovery of Potent Antifungals That Prevent Ras Signaling By Inhibiting Protein Farnesyltransferase. J.Med.Chem. V. 65 13753 2022.
ISSN: ISSN 0022-2623
PubMed: 36218371
DOI: 10.1021/ACS.JMEDCHEM.2C00902
Page generated: Tue Apr 4 17:38:32 2023

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