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Bromine in PDB 7up8: Crystal Structure of C-Terminal Domain of MSK1 in Complex with Covalently Bound Pyrrolopyrimidine Compound 27 (Co-Crystal)Enzymatic activity of Crystal Structure of C-Terminal Domain of MSK1 in Complex with Covalently Bound Pyrrolopyrimidine Compound 27 (Co-Crystal)
All present enzymatic activity of Crystal Structure of C-Terminal Domain of MSK1 in Complex with Covalently Bound Pyrrolopyrimidine Compound 27 (Co-Crystal):
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of C-Terminal Domain of MSK1 in Complex with Covalently Bound Pyrrolopyrimidine Compound 27 (Co-Crystal), PDB code: 7up8
was solved by
J.K.Yano,
J.Abendroth,
A.Hall,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of C-Terminal Domain of MSK1 in Complex with Covalently Bound Pyrrolopyrimidine Compound 27 (Co-Crystal)
(pdb code 7up8). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Crystal Structure of C-Terminal Domain of MSK1 in Complex with Covalently Bound Pyrrolopyrimidine Compound 27 (Co-Crystal), PDB code: 7up8: Jump to Bromine binding site number: 1; 2; Bromine binding site 1 out of 2 in 7up8Go back to Bromine Binding Sites List in 7up8
Bromine binding site 1 out
of 2 in the Crystal Structure of C-Terminal Domain of MSK1 in Complex with Covalently Bound Pyrrolopyrimidine Compound 27 (Co-Crystal)
Mono view Stereo pair view
Bromine binding site 2 out of 2 in 7up8Go back to Bromine Binding Sites List in 7up8
Bromine binding site 2 out
of 2 in the Crystal Structure of C-Terminal Domain of MSK1 in Complex with Covalently Bound Pyrrolopyrimidine Compound 27 (Co-Crystal)
Mono view Stereo pair view
Reference:
A.Hall,
J.Abendroth,
M.J.Bolejack,
T.Ceska,
S.Dell'aiera,
V.Ellis,
D.Fox 3Rd,
C.Francois,
M.M.Muruthi,
C.Prevel,
K.Poullennec,
S.Romanov,
A.Valade,
A.Vanbellinghen,
J.Yano,
M.Geraerts.
Discovery and Characterization of A Novel Series of Chloropyrimidines As Covalent Inhibitors of the Kinase MSK1. Acs Med.Chem.Lett. V. 13 1099 2022.
Page generated: Tue Apr 4 17:40:05 2023
ISSN: ISSN 1948-5875 PubMed: 35859861 DOI: 10.1021/ACSMEDCHEMLETT.2C00134 |
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