Bromine in PDB 7xr6: Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613

The structure of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 also contains other interesting chemical elements:

Fluorine

(F)

6 atoms

The binding sites of Bromine atom in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 (pdb code 7xr6). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 3 binding sites of Bromine where determined in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613, PDB code: 7xr6:
Jump to Bromine binding site number: 1; 2; 3;

Bromine binding site 1 out of 3 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br601 b:60.5 occ:1.00 BR A:GJ0601 0.0 60.5 1.0 C23 A:GJ0601 1.9 60.5 1.0 C25 A:GJ0601 2.9 60.5 1.0 C6 A:GJ0601 2.9 60.5 1.0 O7 A:GJ0601 3.1 60.5 1.0 O5 A:XKJ612 3.2 60.2 1.0 O1 A:XKJ612 3.4 60.2 1.0 C1 A:XKJ612 3.6 60.2 1.0 C2 A:XKJ612 3.6 60.2 1.0 O6 A:XKJ612 3.8 60.2 1.0 C9 A:GJ0601 3.9 60.5 1.0 C8 A:GJ0601 3.9 60.5 1.0 OD2 A:ASP471 4.0 51.9 1.0 C2 A:GJ0601 4.2 60.5 1.0 C5 A:GJ0601 4.2 60.5 1.0 C5 A:XKJ612 4.2 60.2 1.0 C4 A:XKJ612 4.4 60.2 1.0 CG A:LEU447 4.5 35.4 1.0 C3 A:XKJ612 4.6 60.2 1.0 O2 A:XKJ612 4.6 60.2 1.0 C6 A:XKJ612 4.6 60.2 1.0 C3 A:GJ0601 4.7 60.5 1.0 C23 A:XKJ612 4.7 60.2 1.0 CD1 A:LEU447 4.9 35.4 1.0

Bromine binding site 2 out of 3 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ B:Br601 b:59.1 occ:1.00 BR B:GJ0601 0.0 59.1 1.0 C23 B:GJ0601 1.9 59.1 1.0 C25 B:GJ0601 2.9 59.1 1.0 C6 B:GJ0601 2.9 59.1 1.0 O7 B:GJ0601 3.1 59.1 1.0 O5 B:XKJ612 3.3 57.5 1.0 O1 B:XKJ612 3.3 57.5 1.0 C1 B:XKJ612 3.6 57.5 1.0 C2 B:XKJ612 3.6 57.5 1.0 OD2 B:ASP471 3.8 50.2 1.0 C9 B:GJ0601 3.9 59.1 1.0 O6 B:XKJ612 3.9 57.5 1.0 C8 B:GJ0601 3.9 59.1 1.0 C2 B:GJ0601 4.2 59.1 1.0 C5 B:GJ0601 4.2 59.1 1.0 C5 B:XKJ612 4.3 57.5 1.0 C4 B:XKJ612 4.4 57.5 1.0 O2 B:XKJ612 4.5 57.5 1.0 C3 B:XKJ612 4.6 57.5 1.0 C23 B:XKJ612 4.6 57.5 1.0 C3 B:GJ0601 4.7 59.1 1.0 C6 B:XKJ612 4.7 57.5 1.0 CG B:LEU447 4.8 32.8 1.0 C24 B:XKJ612 4.9 57.5 1.0 CG B:ASP471 5.0 50.2 1.0

Bromine binding site 3 out of 3 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ C:Br602 b:59.0 occ:1.00 BR C:GJ0602 0.0 59.0 1.0 C23 C:GJ0602 1.9 59.0 1.0 C25 C:GJ0602 2.9 59.0 1.0 C6 C:GJ0602 2.9 59.0 1.0 O7 C:GJ0602 3.1 59.0 1.0 O5 C:XKJ613 3.3 61.5 1.0 O1 C:XKJ613 3.4 61.5 1.0 C2 C:XKJ613 3.6 61.5 1.0 C1 C:XKJ613 3.6 61.5 1.0 OD2 C:ASP471 3.8 51.8 1.0 C9 C:GJ0602 3.9 59.0 1.0 C8 C:GJ0602 3.9 59.0 1.0 O6 C:XKJ613 4.0 61.5 1.0 C2 C:GJ0602 4.2 59.0 1.0 C5 C:GJ0602 4.2 59.0 1.0 C5 C:XKJ613 4.3 61.5 1.0 C4 C:XKJ613 4.5 61.5 1.0 O2 C:XKJ613 4.5 61.5 1.0 C3 C:XKJ613 4.6 61.5 1.0 C23 C:XKJ613 4.7 61.5 1.0 CG C:LEU447 4.7 33.2 1.0 C3 C:GJ0602 4.7 59.0 1.0 C6 C:XKJ613 4.8 61.5 1.0 CG C:ASP471 4.9 51.8 1.0

Z.Zhang, H.Chen, Z.Geng, Z.Yu, H.Li, Y.Dong, H.Zhang, Z.Huang, J.Jiang, Y.Zhao. Structural Basis of Ligand Binding Modes of Human EAAT2. Nat Commun V. 13 3329 2022.
ISSN: ESSN 2041-1723
PubMed: 35680945
DOI: 10.1038/S41467-022-31031-X